Micafungin
Based on 20 publication(s) in Google Scholar
Micafungin (Mycamine; FK463) is an echinocandin antifungal drug which can inhibit 1,3-beta-D-glucan synthase.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.91%
- CAS No.: 235114-32-6
- Formule: C56H71N9O23S
- Masse moléculaire:1270.27
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Micafungin
More- Exp Mol Med. 2026 Mar;58(2):501-518. [Abstract]
- Chem Biol Interact. 2024 Jul 31:400:111179. [Abstract]
- J Clin Microbiol. 2017 Jun;55(6):1883-1893. [Abstract]
- Antimicrob Agents Chemother. 2023 Aug 17;67(8):e0054323. [Abstract]
- Probiotics Antimicrob Proteins. 2026 Jan 6. [Abstract]
- Appl Microbiol Biotechnol. 2025 Jan 24;109(1):21. [Abstract]
- Microorganisms. 2023 Jun 18;11(6):1608. [Abstract]
- Microorganisms. 2022 Dec 21;11(1):23. [Abstract]
- Sci Rep. 2017 Feb 17;7:42886. [Abstract]
- J Antimicrob Chemother. 2020 Aug 1;75(8):2133-2140. [Abstract]
- PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. [Abstract]
- mSphere. 2020 Oct 28;5(5):e00821-20. [Abstract]
- Mycoses. 2021 Mar;64(3):282-291. [Abstract]
- mSphere. 2018 Nov 14;3(6). pii: e00547-18. [Abstract]
- Infect Drug Resist. 2022 Dec 15:15:7459-7473. [Abstract]
- J Microbiol Methods. 2021 Nov:190:106327. [Abstract]
- University of Szeged. 2026.
- NPJ Antimicrob Resist. 2025 Apr 17;3(1):31. [Abstract]
- bioRxiv. 2025 Feb 6:2025.02.05.636768. [Abstract]
- bioRxiv. 2024 May 14.
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Activité biologique
Chemical Information
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CAS No. 235114-32-6
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Appearance Solid
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Masse moléculaire 1270.27
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Formule C56H71N9O23S
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Color White to off-white
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SMILES
O=C([C@](NC(C(NC([C@@](C[C@@H](O)C1)([H])N1C2=O)=O)[C@H](O)[C@H](C3=CC(OS(=O)(O)=O)=C(O)C=C3)O)=O)([H])[C@H](O)CC(N)=O)N4[C@@](C(N[C@@H]([C@@H](C[C@@H](C(NC2[C@H](O)C)=O)NC(C5=CC=C(C6=NOC(C7=CC=C(OCCCCC)C=C7)=C6)C=C5)=O)O)O)=O)([H])[C@@H](O)[C@@H](C)C4
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Synonyms
FK463
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (20)
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Journal Impact Factor
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Most Recent
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Exp Mol Med
UBE2M as a bridge spanning neddylation and cell cycle regulation in colorectal adenocarcinoma. [Abstract]2026 Mar;58(2):501-518. PMID: 41680469 -
Chem Biol Interact
Micafungin protects mouse heart against doxorubicin-induced oxidative injury via suppressing MALT1-dependent k48-linked ubiquitination of Nrf2. [Abstract]2024 Jul 31:400:111179. PMID: 39089415 -
J Clin Microbiol
Antifungal Susceptibility Testing of Malassezia spp. with an Optimized Colorimetric Broth Microdilution Method. [Abstract]2017 Jun;55(6):1883-1893. PMID: 28381607 -
Antimicrob Agents Chemother
Rapid Evolution of Multidrug Resistance in a Candida lusitaniae Infection during Micafungin Monotherapy. [Abstract]2023 Aug 17;67(8):e0054323. PMID: 37428075
Micafungin purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2023 Aug 17;67(8):e0054323. [Abstract]
Heatmaps of relative growth at increasing concentrations of Micafungin sodium (MICs) and bar charts of tolerance (supra-MIC growth [SMG]) for three drug classes. The MIC is marked with a yellow bar for each isolate.
Micafungin purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2023 Aug 17;67(8):e0054323. [Abstract]
Growth and mean AUC-L values in 0.016 μg/mL MCF. A single isolate (D1.2) did not reach stationary phase and is labeled on the growth curve.
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Probiotics Antimicrob Proteins
Screening the γ-core Motif Peptides of Ascomycetous Antifungal Proteins for Antifungal Activity and Potential Therapeutic Applicability. [Abstract]2026 Jan 6. PMID: 41493708 -
Appl Microbiol Biotechnol
Aloin remodels the cell wall of Candida albicans to reduce its hyphal virulence against oral candidiasis. [Abstract]2025 Jan 24;109(1):21. PMID: 39853490 -
Microorganisms
In Silico Identification and In Vitro Validation of Repurposed Compounds Targeting the RSV Polymerase. [Abstract]2023 Jun 18;11(6):1608. PMID: 37375110 -
Microorganisms
Candida albicans Strains Adapted to Caspofungin Due to Aneuploidy Become Highly Tolerant under Continued Drug Pressure. [Abstract]2022 Dec 21;11(1):23. PMID: 36677315 -
Sci Rep
Biofilm formation of the black yeast-like fungus Exophiala dermatitidis and its susceptibility to antiinfective agents. [Abstract]2017 Feb 17;7:42886. PMID: 28211475 -
J Antimicrob Chemother
Antibiofilm activity of antifungal drugs, including the novel drug olorofim, against Lomentospora prolificans. [Abstract]2020 Aug 1;75(8):2133-2140. PMID: 32386411 -
PLoS Negl Trop Dis
Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti. [Abstract]2019 Aug 20;13(8):e0007681. PMID: 31430351 -
mSphere
Triazole Evolution of Candida parapsilosis Results in Cross-Resistance to Other Antifungal Drugs, Influences Stress Responses, and Alters Virulence in an Antifungal Drug-Dependent Manner. [Abstract]2020 Oct 28;5(5):e00821-20. PMID: 33115837 -
Mycoses
Antifungal susceptibility testing of dermatophytes: Development and evaluation of an optimised broth microdilution method. [Abstract]2021 Mar;64(3):282-291. PMID: 33084127 -
mSphere
Echinocandin-Induced Microevolution of Candida parapsilosis Influences Virulence and Abiotic Stress Tolerance. [Abstract]2018 Nov 14;3(6). pii: e00547-18. PMID: 30429225 -
Infect Drug Resist
Correlation Between Drug Resistance and Virulence of Candida Isolates from Patients with Candidiasis. [Abstract]2022 Dec 15:15:7459-7473. PMID: 36544991 -
J Microbiol Methods
2021 Nov:190:106327. PMID: 34517039 -
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NPJ Antimicrob Resist
Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates. [Abstract]2025 Apr 17;3(1):31. PMID: 40247099 -
bioRxiv
Heterogeneity of Candida bloodstream isolates in an academic medical center and affiliated hospitals. [Abstract]2025 Feb 6:2025.02.05.636768. PMID: 39975022 -
Solvant et solubilité
DMSO : ≥ 100 mg/mL (78.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.97 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (1.97 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7872 mL | 3.9362 mL | 7.8723 mL | 19.6809 mL |
| 5 mM | 0.1574 mL | 0.7872 mL | 1.5745 mL | 3.9362 mL | |
| 10 mM | 0.0787 mL | 0.3936 mL | 0.7872 mL | 1.9681 mL | |
| 15 mM | 0.0525 mL | 0.2624 mL | 0.5248 mL | 1.3121 mL | |
| 20 mM | 0.0394 mL | 0.1968 mL | 0.3936 mL | 0.9840 mL | |
| 25 mM | 0.0315 mL | 0.1574 mL | 0.3149 mL | 0.7872 mL | |
| 30 mM | 0.0262 mL | 0.1312 mL | 0.2624 mL | 0.6560 mL | |
| 40 mM | 0.0197 mL | 0.0984 mL | 0.1968 mL | 0.4920 mL | |
| 50 mM | 0.0157 mL | 0.0787 mL | 0.1574 mL | 0.3936 mL | |
| 60 mM | 0.0131 mL | 0.0656 mL | 0.1312 mL | 0.3280 mL |
Micafungin Related Classifications
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