OUL245
OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM.
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- CAS No.: 1023814-45-0
- Formule: C8H5N3OS
- Masse moléculaire:191.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PARP2 44 nM (IC50) |
PARP-1 570 nM (IC50) |
PARP3 8.8 μM (IC50) |
PARP4 6.0 μM (IC50) |
TNKS1 1.6 μM (IC50) |
TNKS2 370 μM (IC50) |
PARP10 2.9 μM (IC50) |
PARP14 6.7 μM (IC50) |
PARP15 2.0 μM (IC50) |
OUL245 (1 μM; 10-12 d) unlike other derivatives, does not save cells overexpressing PARP10 from ADP ribosylation-dependent cell death[1].
Pharmacokinetic Analysis[1]
| water solubility μg/mL | GI Papp×10-6 cm/s (RM %) | BBB Papp×10-6 cm/s (RM %) | metabolic stablity % | stab in human plasma | stab. in MeOH | stab in PBS pH 7.4 |
| 24.91 | 0.019 | 0.164 | 95.05 | >24 | >24 | >24 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1023814-45-0
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Masse moléculaire 191.21
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Formule C8H5N3OS
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SMILES
C1=CC2=C(C=C1O)SC3=NN=CN23
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OUL245 Related Classifications
HY-W294889 Related Classifications
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