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Cat. No.: HY-181521

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RAPRMT5

RAPRMT5 is a PRMT5 CAP-TAC (proteinase complex-targeted chimeric agent) degrader. RAPRMT5 can induce PRMT5 to undergo proteasome-dependent, ubiquitin-independent degradation. RAPRMT5 can be used in the research of various cancers.
(Pink: PRMT5 ligand (HY-181522); Blue: Proteasome ligand (HY-181523); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2721998-42-9
Formule: C₅₄H₅₈N₁₀O₁₀
Masse moléculaire:1007.10

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

RAPRMT5 Chemical Structure

CAS No.: 2721998-42-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

RAPRMT5 is a PRMT5 CAP-TAC (proteinase complex-targeted chimeric agent) degrader. RAPRMT5 can induce PRMT5 to undergo proteasome-dependent, ubiquitin-independent degradation. RAPRMT5 can be used in the research of various cancers^[1]. (Pink: PRMT5 ligand (HY-181522); Blue: Proteasome ligand (HY-181523); Black: linker).

IC₅₀ & Target^[1]

PRMT5

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

In Vitro

RAPRMT5 (0.1-10 μM; 24-48 h) induces dose-dependent degradation of PRMT5 in HEK293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T
Concentration:

0.1, 0.3, 1.0, 3.0, 10 μM (24 h); 0.1, 0.3, 1.0, 3.0, 10 μM (48 h)
Incubation Time:

24 h; 48 h
Result:

Decreased PRMT5 protein levels in HEK293T cells at all tested concentrations after 24 and 48 h of treatment.

Chemical Information

CAS No. 2721998-42-9
Masse moléculaire 1007.10
Formule C₅₄H₅₈N₁₀O₁₀
SMILES

O=C(N1C/C(C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)=O)=C\C3=CC=C([N+]([O-])=O)C=C3)[C@@H](NC(CCCCCCNC(CNC4=CC(C(NC[C@H](O)CN5CC(C=CC=C6)=C6CC5)=O)=NC=N4)=O)=O)CC7=CC=CC=C7
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Song C, et al. Proteasome Cap Targeting Chimeras for Ubiquitination-Independent Targeted Protein Degradation. Angew Chem Int Ed Engl. 2026;65(9):e20039. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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RAPRMT5

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

RAPRMT5 Related Classifications

HY-181521 Related Classifications