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Cat. No.: HY-160962

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SM1044

SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC₅₀ < 3.6 μM . SM1044 inhbits tumor growth in RL95-2 xenograft mouse model.

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CAS No.: 1331880-08-0
Formule: C₃₄H₅₅NO₁₀
Masse moléculaire:637.80

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SM1044 Chemical Structure

CAS No.: 1331880-08-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
AN3-CA	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1-A	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1B cell line	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
KLE	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
RL95-2	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]

Chemical Information

CAS No. 1331880-08-0
Masse moléculaire 637.80
Formule C₃₄H₅₅NO₁₀
SMILES

C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@@H]1OCCNCCO[C@@H]5[C@@H]([C@@]6([H])[C@]78[C@](O[C@](OO7)(CC[C@@]8([H])[C@@H](CC6)C)C)([H])O5)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhu Y, et al., Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite. Sci Rep. 2019 Oct 29;9(1):15528. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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SM1044

Voir tous les produits spécifiques à Isoform Caspase