STAT3-IN-18
STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.
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- CAS No.: 2668267-41-0
- Formule: C18H24Cl2N2O6Pt
- Masse moléculaire:630.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
STAT3-IN-18 (0.5 μM; 48 h) inhibits the phosphorylation of STAT3 and JAK2, decreases the protein levels of Bcl-2 and COX-2, and increases the protein levels of Bak, Caspase-3, Cleaved PARP1 in MDA-MB-231 cells[1].
STAT3-IN-18 (0.5μM; 36 h) arrests the cell cycle of MDA-MB-231 cells at S phase, (0.5 μM; 48 h) and induces apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2668267-41-0
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Masse moléculaire 630.38
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Formule C18H24Cl2N2O6Pt
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SMILES
[Cl-][Pt+4]([Cl-])([NH3])([NH3])([OH-])[O-]C(COC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (267 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STAT3-IN-18 Related Classifications
HY-155808 Related Classifications
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