TRPM4-IN-2
Based on 6 publication(s) in Google Scholar
TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.17%
- CAS No.: 667411-04-3
- Formule: C19H14ClNO4
- Masse moléculaire:355.77
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Neuronal Signaling Compound Library
HY-L013
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Anti-Cancer Compound Library
HY-L025
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Mechanoreceptors Compound Library
HY-L095
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Anti-Colorectal Cancer Compound Library
HY-L103
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Anti-Prostate Cancer Compound Library
HY-L124
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Pain-Related Compound Library
HY-L139
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Highly Selective Inhibitors Library
HY-L158
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Ion Channel Compound Library
HY-L166
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Publications Citing Use of MedChemExpress (MCE) TRPM4-IN-2
More
Activité biologique
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TRPM4 0.16 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
0.4 μM
Compound: NBA
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Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dye-based fluorescence assay
Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dye-based fluorescence assay
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[PMID: 30708257] |
| LNCaP | IC50 |
>50 μM
Compound: 4; NBA
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Antiproliferative activities against human LNCaP cells assessed as cell viability measured after 72 hrs by CCK8 assay
Antiproliferative activities against human LNCaP cells assessed as cell viability measured after 72 hrs by CCK8 assay
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[PMID: 38168629] |
TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DU145
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Concentration:50 μM
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Incubation Time:0-500 s
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Result:Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.
Chemical Information
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CAS No. 667411-04-3
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Appearance Solid
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Masse moléculaire 355.77
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Formule C19H14ClNO4
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(Cl)C=C1NC(COC2=C3C=CC=CC3=CC=C2)=O
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Synonyms
NBA
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Immunotargets Ther
Comprehensive Insights Into the Role of TRPM4 in Pan-Cancer Progression and Immune Regulation. [Abstract]2025 Aug 20:14:831-848. PMID: 40860345 -
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Pharmacol Res Perspect
NMDA Receptor-Mediated Ca2+ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin. [Abstract]2024 Dec;12(6):e70038. PMID: 39574295 -
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Solvant et solubilité
DMSO : 100 mg/mL (281.08 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Borgström A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665. [Content Brief]
[2]. Stokłosa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8108 mL | 14.0540 mL | 28.1080 mL | 70.2701 mL |
| 5 mM | 0.5622 mL | 2.8108 mL | 5.6216 mL | 14.0540 mL | |
| 10 mM | 0.2811 mL | 1.4054 mL | 2.8108 mL | 7.0270 mL | |
| 15 mM | 0.1874 mL | 0.9369 mL | 1.8739 mL | 4.6847 mL | |
| 20 mM | 0.1405 mL | 0.7027 mL | 1.4054 mL | 3.5135 mL | |
| 25 mM | 0.1124 mL | 0.5622 mL | 1.1243 mL | 2.8108 mL | |
| 30 mM | 0.0937 mL | 0.4685 mL | 0.9369 mL | 2.3423 mL | |
| 40 mM | 0.0703 mL | 0.3514 mL | 0.7027 mL | 1.7568 mL | |
| 50 mM | 0.0562 mL | 0.2811 mL | 0.5622 mL | 1.4054 mL | |
| 60 mM | 0.0468 mL | 0.2342 mL | 0.4685 mL | 1.1712 mL | |
| 80 mM | 0.0351 mL | 0.1757 mL | 0.3514 mL | 0.8784 mL | |
| 100 mM | 0.0281 mL | 0.1405 mL | 0.2811 mL | 0.7027 mL |
TRPM4-IN-2 Related Classifications
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