UNC7242
UNC7242 is an antagonist that binds to the Tudor domains of PHF1 and PHF19, with a Kd of 1.13 μM for PHF1 and 0.64 μM for PHF19. UNC7242 fails to displace full-length PHF1 or PHF19 from H3K36me3 nucleosomes or chromatin. UNC7242 can be used in studies related to multiple myeloma, endometrial stromal sarcoma, and ossifying fibromyxoid tumor.
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- Formule: C19H25ClN4O2
- Masse moléculaire:376.88
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
UNC7242 binds to the isolated PHF1 Tudor domain with a Kd value of 1.13 ± 0.04 μM, and binds to the isolated PHF19 Tudor domain with a Kd value of 0.64 ± 0.14 μM[1].
UNC7242 (100 μM; 2 h) does not significantly displace endogenous PHF19 from chromatin in Jurkat N6 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 376.88
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Formule C19H25ClN4O2
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SMILES
COC1=CC2=NC(Cl)=NC(N3CCCN(CC3)CC4CC4)=C2C=C1OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC7242 Related Classifications
HY-181914 Related Classifications
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