Cyclosporin G
Based on 1 Customer Validation
Cyclosporin G is an active metabolite that can be produced from Tolypocladium inflatum. Cyclosporin G has immunosuppressive activity. Cyclosporin G inhibits proliferation of A431 cells.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 95.0%
- CAS No.: 74436-00-3
- 화학식: C63H113N11O12
- 분자량:1216.64
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- Protocol
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
Chemical Information
-
CAS No. 74436-00-3
-
Appearance Solid
-
분자량 1216.64
-
화학식 C63H113N11O12
-
Color White to off-white
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : ≥ 100 mg/mL (82.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
-
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
순도&문서
-
Data Sheet (279 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Burdmann EA, et al. Experimental nephrotoxicity, hepatotoxicity and pharmacokinetics of cyclosporin G versus cyclosporin A. Kidney Int. 1994 Mar;45(3):684-91. [Content Brief]
[2]. Teofoli P, et al. Cyclosporin G inhibits proliferation of A431 cells in a dose- and time-dependent manner comparable to cyclosporin A. Skin Pharmacol. 1997;10(2):79-84. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8219 mL | 4.1097 mL | 8.2194 mL | 20.5484 mL |
| 5 mM | 0.1644 mL | 0.8219 mL | 1.6439 mL | 4.1097 mL | |
| 10 mM | 0.0822 mL | 0.4110 mL | 0.8219 mL | 2.0548 mL | |
| 15 mM | 0.0548 mL | 0.2740 mL | 0.5480 mL | 1.3699 mL | |
| 20 mM | 0.0411 mL | 0.2055 mL | 0.4110 mL | 1.0274 mL | |
| 25 mM | 0.0329 mL | 0.1644 mL | 0.3288 mL | 0.8219 mL | |
| 30 mM | 0.0274 mL | 0.1370 mL | 0.2740 mL | 0.6849 mL | |
| 40 mM | 0.0205 mL | 0.1027 mL | 0.2055 mL | 0.5137 mL | |
| 50 mM | 0.0164 mL | 0.0822 mL | 0.1644 mL | 0.4110 mL | |
| 60 mM | 0.0137 mL | 0.0685 mL | 0.1370 mL | 0.3425 mL | |
| 80 mM | 0.0103 mL | 0.0514 mL | 0.1027 mL | 0.2569 mL |
Cyclosporin G Related Classifications
HY-105023 Related Classifications
Powered by Bioz