IMM-H007
Based on 1 Customer Validation
IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis.
For research use only. We do not sell to patients.
- Purity: 97.69%
- CAS No.: 1221412-23-2
- Formula: C22H23N5O8
- Molecular Weight:485.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
IMM-H007 (200 mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1221412-23-2
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Appearance Solid
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Molecular Weight 485.45
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Formula C22H23N5O8
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Color White to off-white
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SMILES
CC(O[C@H]1[C@@](N2C3=NC=NC(NC4=CC(O)=CC=C4)=C3N=C2)([H])O[C@@H]([C@H]1OC(C)=O)COC(C)=O)=O
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Synonyms
WS070117
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 125 mg/mL (257.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Yu J, et al. IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling. Toxicol Appl Pharmacol. 2019 Oct 15;381:114732. [Content Brief]
[2]. Shi H, et al. IMM-H007, a new therapeutic candidate for nonalcoholic fatty liver disease, improves hepatic steatosis in hamsters fed a high-fat diet. FEBS Open Bio. 2017 Aug 29;7(9):1379-1391. [Content Brief]
[3]. Wang SX, et al. IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway. Acta Pharmacol Sin. 2022 Mar 30. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0599 mL | 10.2997 mL | 20.5994 mL | 51.4986 mL |
| 5 mM | 0.4120 mL | 2.0599 mL | 4.1199 mL | 10.2997 mL | |
| 10 mM | 0.2060 mL | 1.0300 mL | 2.0599 mL | 5.1499 mL | |
| 15 mM | 0.1373 mL | 0.6866 mL | 1.3733 mL | 3.4332 mL | |
| 20 mM | 0.1030 mL | 0.5150 mL | 1.0300 mL | 2.5749 mL | |
| 25 mM | 0.0824 mL | 0.4120 mL | 0.8240 mL | 2.0599 mL | |
| 30 mM | 0.0687 mL | 0.3433 mL | 0.6866 mL | 1.7166 mL | |
| 40 mM | 0.0515 mL | 0.2575 mL | 0.5150 mL | 1.2875 mL | |
| 50 mM | 0.0412 mL | 0.2060 mL | 0.4120 mL | 1.0300 mL | |
| 60 mM | 0.0343 mL | 0.1717 mL | 0.3433 mL | 0.8583 mL | |
| 80 mM | 0.0257 mL | 0.1287 mL | 0.2575 mL | 0.6437 mL | |
| 100 mM | 0.0206 mL | 0.1030 mL | 0.2060 mL | 0.5150 mL |
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