RN-9893
Based on 1 Customer Validation
RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 1803003-68-0
- Formula: C21H23F3N4O5S
- Molecular Weight:500.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>10 μM
Compound: 26, RN-9893
|
Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins
Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins
|
[PMID: 26235950] |
| HEK293 | IC50 |
>30 μM
Compound: 26, RN-9893
|
Antagonist activity at human TRPV3 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins
Antagonist activity at human TRPV3 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins
|
[PMID: 26235950] |
| HEK293 | IC50 |
0.057 μM
Compound: 26, RN-9893
|
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins
|
[PMID: 26235950] |
| HEK293 | IC50 |
0.12 μM
Compound: 26, RN-9893
|
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins
|
[PMID: 26235950] |
| HEK293 | IC50 |
0.32 μM
Compound: 26, RN-9893
|
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins
|
[PMID: 26235950] |
| HEK293 | IC50 |
0.42 μM
Compound: 26, RN-9893
|
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins
|
[PMID: 26235950] |
| HEK293 | IC50 |
0.57 μM
Compound: 26, RN-9893
|
Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx
Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx
|
[PMID: 26235950] |
| HEK293 | IC50 |
0.66 μM
Compound: 26, RN-9893
|
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins
|
[PMID: 26235950] |
| HEK293 | IC50 |
2.1 μM
Compound: 26, RN-9893
|
Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx
Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx
|
[PMID: 26235950] |
| HEK293 | IC50 |
30 μM
Compound: 26, RN-9893
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Antagonist activity at human TRPM8 receptor expressed in HEK293 cells assessed as inhibition of menthol-stimulated calcium flux after 10 mins
Antagonist activity at human TRPM8 receptor expressed in HEK293 cells assessed as inhibition of menthol-stimulated calcium flux after 10 mins
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[PMID: 26235950] |
Chemical Information
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CAS No. 1803003-68-0
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Appearance Solid
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Molecular Weight 500.49
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Formula C21H23F3N4O5S
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Color White to off-white
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SMILES
O=S(C(C=C1)=CC=C1NC(C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2)=O)(N3CCN(C(C)C)CC3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (499.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9980 mL | 9.9902 mL | 19.9804 mL | 49.9510 mL |
| 5 mM | 0.3996 mL | 1.9980 mL | 3.9961 mL | 9.9902 mL | |
| 10 mM | 0.1998 mL | 0.9990 mL | 1.9980 mL | 4.9951 mL | |
| 15 mM | 0.1332 mL | 0.6660 mL | 1.3320 mL | 3.3301 mL | |
| 20 mM | 0.0999 mL | 0.4995 mL | 0.9990 mL | 2.4976 mL | |
| 25 mM | 0.0799 mL | 0.3996 mL | 0.7992 mL | 1.9980 mL | |
| 30 mM | 0.0666 mL | 0.3330 mL | 0.6660 mL | 1.6650 mL | |
| 40 mM | 0.0500 mL | 0.2498 mL | 0.4995 mL | 1.2488 mL | |
| 50 mM | 0.0400 mL | 0.1998 mL | 0.3996 mL | 0.9990 mL | |
| 60 mM | 0.0333 mL | 0.1665 mL | 0.3330 mL | 0.8325 mL | |
| 80 mM | 0.0250 mL | 0.1249 mL | 0.2498 mL | 0.6244 mL | |
| 100 mM | 0.0200 mL | 0.0999 mL | 0.1998 mL | 0.4995 mL |
RN-9893 Related Classifications
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