ROS1 - ROS proto-oncogene 1, receptor tyrosine kinase Gene

Also Known as ROS; MCF3; c-ros-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6098

About ROS1

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:117,287,353-117,425,942 (from NCBI)

This gene has 3 transcripts (splice variants), 125 orthologues, 53 paralogues and is associated with 133 phenotypes. Restricted expression toward lung (RPKM 10.3).

Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase Insulin Receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

ROS1 Products (17)

mRNA Protein Name
NM_001378891.1 NP_001365820.1 proto-oncogene tyrosine-protein kinase ROS isoform 2 precursor
XM_011536054.3 XP_011534356.1 proto-oncogene tyrosine-protein kinase ROS isoform X8
NM_002944.3 NP_002935.2 proto-oncogene tyrosine-protein kinase ROS isoform 1 precursor
XM_011536058.3 XP_011534360.1 proto-oncogene tyrosine-protein kinase ROS isoform X12
XM_011536056.3 XP_011534358.1 proto-oncogene tyrosine-protein kinase ROS isoform X10
XM_011536049.3 XP_011534351.1 proto-oncogene tyrosine-protein kinase ROS isoform X1
XM_047419232.1 XP_047275188.1 proto-oncogene tyrosine-protein kinase ROS isoform X14
XM_011536050.3 XP_011534352.1 proto-oncogene tyrosine-protein kinase ROS isoform X2
XM_011536053.3 XP_011534355.1 proto-oncogene tyrosine-protein kinase ROS isoform X7
XM_011536055.3 XP_011534357.1 proto-oncogene tyrosine-protein kinase ROS isoform X9
XM_006715548.5 XP_006715611.1 proto-oncogene tyrosine-protein kinase ROS isoform X4
XM_011536057.4 XP_011534359.1 proto-oncogene tyrosine-protein kinase ROS isoform X11
XM_047419231.1 XP_047275187.1 proto-oncogene tyrosine-protein kinase ROS isoform X13
NM_001378902.1 NP_001365831.1 proto-oncogene tyrosine-protein kinase ROS isoform 3 precursor
XM_017011173.2 XP_016866662.1 proto-oncogene tyrosine-protein kinase ROS isoform X6
XM_011536051.3 XP_011534353.1 proto-oncogene tyrosine-protein kinase ROS isoform X3
XM_017011172.2 XP_016866661.1 proto-oncogene tyrosine-protein kinase ROS isoform X5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17416557 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
16885344 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
16885344 GOA
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
16885344 GOA
involved in regulation of TOR signaling IDA
IDA: Inferred from direct assay
16885344 GOA
involved in regulation of cell growth IDA
IDA: Inferred from direct assay
16885344 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROS1 Protein Structure

fn3

fn3: Fibronectin type III domain (102 - 169)

fn3

fn3: Fibronectin type III domain (202 - 274)

fn3

fn3: Fibronectin type III domain (1061 - 1138)

fn3

fn3: Fibronectin type III domain (1668 - 1738)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (1947 - 2215)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2347 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase ROS

  • ROS proto-oncogene 1 , receptor tyrosine kinase

  • c-ros oncogene 1 , receptor tyrosine kinase

  • proto-oncogene c-Ros-1

  • transmembrane tyrosine-specific protein kinase

  • v-ros avian UR2 sarcoma virus oncogene homolog 1

ROS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ROS1 P08922 PTPN6 Homo sapiens P29350
Phosphatase Assay
17416557
Intra
ROS1 P08922 PTPN1 Homo sapiens P18031
Phosphatase Assay
17416557
Cross: Cross-species interaction Intra: Intraspecies interaction

ROS1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87054 ROS1 Antibody (YA6747) IHC-P Human

Related Diseases

Diseases Alias
Infantile Myofibromatosis

  • Lipofibromatosis

  • Myofibromatosis
Childhood Angiosarcoma

  • Paediatric Angiosarcoma

  • Paediatric Hemangiosarcoma

  • Pediatric Angiosarcoma

  • Pediatric Hemangiosarcoma
Lung Combined Large Cell Neuroendocrine Carcinoma

  • Combined Large Cell Neuroendocrine Carcinoma Of Lung

  • Pulmonary Combined Large Cell Neuroendocrine Carcinoma

  • Combined Large Cell Lung Neuroendocrine Carcinoma
Gastrointestinal Stromal Tumor

  • GIST

  • Gastrointestinal Stromal Tumors

  • Gastrointestinal Stromal Sarcoma

  • Gastrointestinal Stromal Tumor, Familial

  • Gant

  • Gastrointestinal Stromal Tumour

  • Stromal Tumor Of Gastrointestinal Tract

  • Stromal Tumour Of Gastrointestinal Tract

  • Gastrointestinal Stromal Neoplasm

  • Paraganglioma And Gastric Stromal Sarcoma

  • Plexosarcoma
Malignant Giant Cell Tumor Of The Tendon Sheath

  • Giant Cell Tumour Of Tendon Sheath, Malignant

  • Malignant Giant Cell Neoplasm Of The Tendon Sheath
Mucinous Adenocarcinoma

  • Mucin-Producing Adenocarcinoma

  • Mucin-Secreting Adenocarcinoma

  • Mucin-Secreting Carcinoma

  • Mucous Carcinoma

  • Pseudomyxoma Peritonei With Unknown Primary Site

  • Adenocarcinoma, Mucinous
Pleomorphic Carcinoma
Mesenchymal Cell Neoplasm

  • Benign Miscellaneous Mesenchymal Tumor

  • Mesenchymal Tumor

  • Mesenchymal Tumors
Lung Sarcomatoid Carcinoma

  • Pulmonary Sarcomatoid Carcinoma

  • Sarcomatoid Carcinoma Of The Lung
Mucinous Lung Adenocarcinoma
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Solid Adenocarcinoma With Mucin Production
Large Cell Neuroendocrine Carcinoma
Thyroid Gland Hurthle Cell Carcinoma

  • Oncocytic Carcinoma Of The Thyroid

  • Thyroid Cancer, Hurthle Cell
Cholangiocarcinoma

  • Cholangiocarcinoma, Susceptibility To

  • Extrahepatic Cholangiocarcinoma

  • Intrahepatic Cholangiocarcinoma

  • Chlc

  • Chlc, Susceptibility To

  • Cc

  • Cholangiocarcinoma Of Biliary Tract

  • Cholangiocellular Carcinoma

  • Distal Cholangiocarcinoma

  • Perihilar Cholangiocarcinoma

  • Bile Duct Cancer

  • Cca

  • Adult Primary Cholangiocellular Carcinoma

  • Bile Duct Carcinoma
Lung Cancer Susceptibility 3

  • Lung Adenocarcinoma

  • Adenocarcinoma Of Lung

  • LNCR3

  • Adenocarcinoma Of Lung, Susceptibility To

  • Bronchogenic Lung Adenocarcinoma

  • Nonsmall Cell Adenocarcinoma

  • Adenocarcinoma Lung

  • Lung Adenocarcinomas

  • Non-Small Cell Adenocarcinoma
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Lung Large Cell Carcinoma

  • Large Cell Carcinoma Of Lung

  • Large Cell Lung Carcinoma

  • Large Cell Lung Cancer
Adenosquamous Carcinoma

  • Adenosquamous Cell Carcinoma

  • Mixed Adenocarcinoma And Squamous Carcinoma

  • Carcinoma Adenosquamous

  • Carcinoma, Adenosquamous
Spinal Cord Melanoma

  • Melanoma Of The Spinal Cord
Childhood Fibrosarcoma

  • Pediatric Fibrosarcoma
Occipital Lobe Neoplasm

  • Neoplasm Of Occipital Lobe

  • Malignant Neoplasm Of Occipital Lobe

  • Tumor Of Occipital Lobe
Congenital Mesoblastic Nephroma

  • Nephroma, Mesoblastic

  • Mesoblastic Nephroma
Spitzoid Melanoma

  • Atypical Spitz Nevus
Pulmonary Plasma Cell Granuloma

  • Plasma Cell Granuloma, Pulmonary

  • Granuloma, Plasma Cell, Pulmonary

  • Lymphocytic Pseudotumor Of Lung

  • Sclerosing Hemangiocytoma Of Lung
Angiosarcoma

  • Hemangiosarcoma
Trichothiodystrophy 4, Nonphotosensitive

  • Amish Brittle Hair Brain Syndrome

  • TTD4

  • Trichothiodystrophy, Nonphotosensitive 1

  • Hair-Brain Syndrome

  • Bids Syndrome

  • Ttdn1

  • Abhs

  • Pollitt Syndrome

  • Trichothiodystrophy-Neurocutaneous Syndrome

  • Nonphotosensitive Trichothiodystrophy 4

  • Trichorrhexis Nodosa Syndrome

  • Trichothiodystrophy 4, Non-Photosensitive

  • Trichothiodystrophy Non-Photosensitive 1
Inflammatory Myofibroblastic Tumor

  • Inflammatory Fibrosarcoma
Congenital Fibrosarcoma

  • Infantile Fibrosarcoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Lymphangitis

  • Inflammation Of Lymphatics
Fasciitis
Gastric Cancer

  • Stomach Cancer

  • Stomach Carcinoma

  • Gastric Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Mammary Analogue Secretory Carcinoma
Lung Non-Squamous Non-Small Cell Carcinoma

  • Non- Squamous Nsclc
Adenocarcinoma In Situ
Large Cell Carcinoma

  • Carcinoma, Large Cell

  • Carcinoma Large Cell
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Cancer Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Protection Against

  • Lung Cancer, Susceptibility To

  • Adenocarcinoma Of Lung, Somatic

  • Nonsmall Cell Lung Cancer

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Main Bronchus Cancer

  • Malignant Neoplasm Of Main Bronchus

  • Ca Main Bronchus
Adenocarcinoma

  • Adenocarcinomas

  • Adenoacanthoma Of Unspecified Site

  • Adenocarcinoid Of Unspecified Site

  • Adenocarcinoid Tumour Of Unspecified Site

  • Adenocarcinoma And Carcinoid Combined Of Unspecified Site

  • Adenocarcinoma Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50878 Crizotinib Inhibitor 99.97% Yes
HY-12215 Lorlatinib 99.99% Yes
HY-W015913 Pyruvic acid sodium Inhibitor 99.86% Yes
HY-12678 Entrectinib 99.26% Yes
HY-103022 Repotrectinib Inhibitor 99.95% Unkown
HY-131003 Taletrectinib Inhibitor 99.63% Unkown
HY-50878A Crizotinib hydrochloride 99.86% Yes
HY-145574 Iruplinalkib Inhibitor 99.62% Unkown
HY-12215R Lorlatinib (Standard) 99.92% Unkown
HY-50878B Crizotinib acetate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-112801 F-1 Inhibitor 98.03% Phase 3
HY-176942 JYP0322 Inhibitor / Phase 3
HY-152292 Zidesamtinib Inhibitor 99.78% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
HY-155163 APG-2449 Inhibitor 98.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (56)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0578 Apigenin 7-glucoside 98.98% Unkown
HY-W015913S Pyruvic acid-13C3 sodium Inhibitor 99.7% Unkown
HY-15514 Merestinib Inhibitor 99.99% Yes
HY-122311 Orniplabin Inhibitor 98% Unkown
HY-159147 SIA​​IS039 99.68% Unkown
HY-12678S1 Entrectinib-d8 99.82% Unkown
HY-N7798 Pennogenin 99.90% Unkown
HY-50878S Crizotinib-d5 99.60% Unkown
HY-B1106 Tetrahydroxyquinone 98.0% Unkown
HY-12678S Entrectinib-d4 Inhibitor / Unkown
HY-B1106A Tetrahydroxyquinone monohydrate 97.0% Unkown
HY-N10144 Shinpterocarpin Inhibitor / Unkown
HY-N1306 Sideroxylin / Unkown
HY-N2693 6,8-Diprenylorobol 98.40% Unkown
HY-W015913R Pyruvic acid sodium (Standard) Inhibitor 99.98% Unkown
HY-161358 FAK-IN-20 / Unkown
HY-111416 WY-135 Inhibitor / Unkown
HY-131003A Taletrectinib free base Inhibitor / Unkown
HY-135509 Lorlatinib acetate / Unkown
HY-115541 BRD4-IN-41 Inhibitor / Unkown
HY-117420 CM764 Activator / Unkown
HY-120387 SMU-B Inhibitor / Unkown
HY-122311A Bis(2R,3R)-Orniplabin 95.0% Unkown
HY-123454 SKF1 / Unkown
HY-130794 ALK/ROS1-IN-1 Inhibitor / Unkown
HY-144697 p38 MAPK-IN-3 / Unkown
HY-147795 Nampt-IN-8 / Unkown
HY-150974 ROS1-IN-1 Inhibitor / Unkown
HY-153743 Protein kinase inhibitor 4 Inhibitor / Unkown
HY-155178 Antiproliferative agent-34 Inhibitor / Unkown
HY-156360 Xanthine oxidase-IN-12 Inhibitor / Unkown
HY-157391 ALK/ROS1-IN-3 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-158016 Antiproliferative agent-49 / Unkown
HY-161966 VEGFR-2-IN-52 / Unkown
HY-161975 ROS1-IN-2 Inhibitor / Unkown
HY-162311 Anticancer agent 194 / Unkown
HY-163862 PPARα agonist 3 / Unkown
HY-170418 ALK/ROS1-IN-5 / Unkown
HY-178391 SMU-037 / Unkown
HY-179052 Apoptosis inducer 50 / Unkown
HY-179527 LIG48 Inhibitor / Unkown
HY-50878AS Crizotinib-d9 hydrochloride / Unkown
HY-N11887 Linocinnamarin Inhibitor 99.14% Unkown
HY-RS12135 ROS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12136 Ros1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12137 ROS1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160172 ALK/ROS1-IN-4 Inhibitor / Unkown
HY-160172A ALK/ROS1-IN-4 hydrate Inhibitor / Unkown
HY-162488 Laccase-IN-3 Inhibitor / Unkown
HY-179710 SET-12 / Unkown
HY-50878S1 Crizotinib-d8 / Unkown
HY-50878S2 Crizotinib-d9 / Unkown
HY-B0847S Propiconazole-d7 / Unkown
HY-W587743 N1-Acetyl-5-methoxykynuramine hydrochloride Inhibitor / Unkown
HY-W927359 Fluorescein hydrazide (3,6-Dihydroxyxanthane) / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ROS1 VGNC VGNC:34091
Canis familiaris ROS1 VGNC VGNC:45698
Rattus norvegicus ROS1 RGD RGD:3591
Felis catus ROS1 VGNC VGNC:64724
Mus musculus ROS1 MGD MGI:97999
Others ROS1 NCBI