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Cat. No.: HY-160962

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SM1044

SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC₅₀ < 3.6 μM . SM1044 inhbits tumor growth in RL95-2 xenograft mouse model.

For research use only. We do not sell to patients.

CAS No.: 1331880-08-0
Formula: C₃₄H₅₅NO₁₀
Molecular Weight:637.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SM1044 Chemical Structure

CAS No.: 1331880-08-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
AN3-CA	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1-A	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1B cell line	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
KLE	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
RL95-2	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]

Chemical Information

CAS No. 1331880-08-0
Molecular Weight 637.80
Formula C₃₄H₅₅NO₁₀
SMILES

C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@@H]1OCCNCCO[C@@H]5[C@@H]([C@@]6([H])[C@]78[C@](O[C@](OO7)(CC[C@@]8([H])[C@@H](CC6)C)C)([H])O5)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu Y, et al., Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite. Sci Rep. 2019 Oct 29;9(1):15528. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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SM1044

All Caspase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SM1044 Related Classifications

HY-160962 Related Classifications