1. Epigenetics
  2. Histone Methyltransferase
  3. (S)-Pociredir

(S)-Pociredir  (Synonyms: (S)-FTX-6058)

Cat. No.: HY-139400 Purity: 99.97%
COA Handling Instructions

(S)-Pociredir ((S)-FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). (S)-Pociredir can induce HbF protein expression in cell and murine models. (S)-Pociredir can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia.

For research use only. We do not sell to patients.

(S)-Pociredir Chemical Structure

(S)-Pociredir Chemical Structure

CAS No. : 2490676-18-9

Size Price Stock Quantity
5 mg USD 1480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2450 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-Pociredir:

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Description

(S)-Pociredir ((S)-FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). (S)-Pociredir can induce HbF protein expression in cell and murine models. (S)-Pociredir can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia[1][2].

In Vitro

(S)-Pociredir inhibits PRC2 via binding to EED, which induces robust HbF protein expression in both cell and murine models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

403.41

Formula

C22H18FN5O2

CAS No.
SMILES

FC1=C2C3=C(C=C1)OC[[email protected]@]3([H])COC4=C(N5C(C(C6=C(N=CC=C6)C)=C4)=NN=C5)NC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (309.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4789 mL 12.3943 mL 24.7887 mL
5 mM 0.4958 mL 2.4789 mL 4.9577 mL
10 mM 0.2479 mL 1.2394 mL 2.4789 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.16 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
(S)-Pociredir
Cat. No.:
HY-139400
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