AS-252424
Based on 8 publication(s) in Google Scholar
AS-252424 is a potent and selective PI3Kγ inhibitor with an IC50 of 30±10 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.66%
- No. CAS: 900515-16-4
- Fòrmula: C14H8FNO4S
- Peso molecular:305.28
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) AS-252424
More- J Adv Res. 2025 Aug:74:237-253. [Abstract]
- Cell Death Differ. 2025 Oct 7. [Abstract]
- Sci China Chem. 2025 Jun 30.
- Molecules. 2020 Apr 23;25(8):1980. [Abstract]
- J Mol Med (Berl). 2018 Feb;96(2):119-133. [Abstract]
- J Biol Chem. 2020 May 22;295(21):7431-7441. [Abstract]
- bioRxiv. 2026 May 7.
- Biomed Pharmacother. 2025 Jul:188:118222. [Abstract]
Customer Validation & Images
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Bio/Physico-chemical Assay
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Histological Imaging/Staining
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WB
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Cell Migration/Invasion Assay
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Cell Migration/Invasion Assay
Actividad biológica
Descripciòn
IC50 & Target
[1]|
PI3Kγ 30 nM (IC50) |
PI3Kα 935 nM (IC50) |
PI3Kδ 20 μM (IC50) |
PI3Kβ 20 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Monocyte | IC50 |
53 μM
Compound: 26
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Inhibition of MCP1-induced chemotaxis of mouse primary monocytes
Inhibition of MCP1-induced chemotaxis of mouse primary monocytes
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[PMID: 16789742] |
| RAW264.7 | IC50 |
0.23 μM
Compound: 26
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Inhibition of C5a-mediated PKB/Akt phosphorylation in mouse Raw264 macrophage
Inhibition of C5a-mediated PKB/Akt phosphorylation in mouse Raw264 macrophage
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[PMID: 16789742] |
| THP-1 | IC50 |
0.4 μM
Compound: 26
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Inhibition of MCP1-induced PKB/Akt phosphorylation in THP1 cells
Inhibition of MCP1-induced PKB/Akt phosphorylation in THP1 cells
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[PMID: 16789742] |
| THP-1 | IC50 |
4.73 μM
Compound: 26
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Inhibition of SCF1-induced PKB/Akt phosphorylation in THP1 cells
Inhibition of SCF1-induced PKB/Akt phosphorylation in THP1 cells
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[PMID: 16789742] |
| THP-1 | IC50 |
53 μM
Compound: 26
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Inhibition of MCP1-induced chemotaxis of THP1 cells
Inhibition of MCP1-induced chemotaxis of THP1 cells
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[PMID: 16789742] |
In Vitro
AS-252424 also inhibits PI3Kα, PI3Kβ and PI3Kδ with IC50s of 935±150 nM, 20 μM and 20 μM, respectively. AS-252424 inhibits MCP-1-mediated chemotaxis in wild-type primary monocytes in a concentration-dependent manner with an IC50 value of 52 μM, as well as in the monocytic cell line THP-1 with an IC50 value of 53 μM. In the human monocytic cell line THP-1, MCP-1 binding to the GPCR chemokine receptor CCR2, strongly induces phosphorylation of PKB/Akt, which is effectively inhibited by AS-252424 at IC50 values as low as 0.4 μM. In contrast, induction of PKB/Akt phosphorylation by colony stimulating factor (CSF-1), binding to the growth factor receptor c-fms, is only blocked by AS-252424 at IC50 values as high as 4.7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 900515-16-4
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Appearance Solid
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Peso molecular 305.28
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Fòrmula C14H8FNO4S
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Color Light yellow to brown
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SMILES
O=C(NC/1=O)SC1=C/C2=CC=C(C3=CC=C(F)C=C3O)O2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (8)
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Journal Impact Factor
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Most Recent
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J Adv Res
The fatty acid receptor CD36 promotes macrophage infiltration via p110γ signaling to stimulate metastasis. [Abstract]2025 Aug:74:237-253. PMID: 39419288
AS-252424 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:237-253. [Abstract]
AS-252424 (AS252424; 10 mg/kg; i.p.; daily for 10 days) significantly suppressed metastatic tumor formation and the accumulation of tumor-associated macrophages (TAMs) in the liver, while there was no significant difference between WT and Cd36MKO mice upon treatment with AS252424.
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Cell Death Differ
PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury. [Abstract]2025 Oct 7. PMID: 41057687 -
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Molecules
In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei. [Abstract]2020 Apr 23;25(8):1980. PMID: 32340370 -
J Mol Med (Berl)
PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-β1 signaling to PI3Kγ/AKT/Rac1 pathway. [Abstract]2018 Feb;96(2):119-133. PMID: 29098317
AS-252424 purchased from MedChemExpress. Usage Cited in: J Mol Med (Berl). 2018 Feb;96(2):119-133. [Abstract]
The regulation of PHP14 on Akt phosphorylation is possibly via PI3Kγ in LX-2 cells. Cells are serum starvation 24 h, then treated TGF-β1 (10 ng/mL) 2 h, then added LY294002 (5 μM) or AS252424 (10 μM) as indicated; after another 2 h incubation, Western blot is performed to assess the protein expression of p-Akt.
AS-252424 purchased from MedChemExpress. Usage Cited in: J Mol Med (Berl). 2018 Feb;96(2):119-133. [Abstract]
AS-252424 (AS252424; 10 μM; 24, 48 h) inhibited the increase in migration induced by PHP14 overexpression in LX-2 cells.
AS-252424 purchased from MedChemExpress. Usage Cited in: J Mol Med (Berl). 2018 Feb;96(2):119-133. [Abstract]
AS-252424 (AS252424; 10 μM) inhibited the increased migration of primary rat HSCs induced by PHP14 overexpression.
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J Biol Chem
The mTOR inhibitor manassantin B reveals a crucial role of mTORC2 signaling in Epstein-Barr virus reactivation. [Abstract]2020 May 22;295(21):7431-7441. PMID: 32312752 -
AS-252424 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 May 7.
AS-252424 (0, 5,10, 20 μM) decreased pS129 level primary neurons with aSyn PFF.
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Biomed Pharmacother
Lutein attenuates rhabdomyolysis-induced acute kidney injury by inhibiting ACSL4-mediated ferroptosis. [Abstract]2025 Jul:188:118222. PMID: 40460552
Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (81.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2757 mL | 16.3784 mL | 32.7568 mL | 81.8920 mL |
| 5 mM | 0.6551 mL | 3.2757 mL | 6.5514 mL | 16.3784 mL | |
| 10 mM | 0.3276 mL | 1.6378 mL | 3.2757 mL | 8.1892 mL | |
| 15 mM | 0.2184 mL | 1.0919 mL | 2.1838 mL | 5.4595 mL | |
| 20 mM | 0.1638 mL | 0.8189 mL | 1.6378 mL | 4.0946 mL | |
| 25 mM | 0.1310 mL | 0.6551 mL | 1.3103 mL | 3.2757 mL | |
| 30 mM | 0.1092 mL | 0.5459 mL | 1.0919 mL | 2.7297 mL | |
| 40 mM | 0.0819 mL | 0.4095 mL | 0.8189 mL | 2.0473 mL | |
| 50 mM | 0.0655 mL | 0.3276 mL | 0.6551 mL | 1.6378 mL | |
| 60 mM | 0.0546 mL | 0.2730 mL | 0.5459 mL | 1.3649 mL | |
| 80 mM | 0.0409 mL | 0.2047 mL | 0.4095 mL | 1.0237 mL |
AS-252424 Related Classifications
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