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Referencia número: HY-182439

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AZD3778

AZD3778 (Compound 8) is an inhibitor of CCR3 and histamine H1 receptor (histamine H1 receptor), with IC₅₀ values of 8.1 nM and 40 nM, respectively. AZD3778 inhibits the binding of eosinophil chemokines to CCR3, as well as the binding of histamine to histamine H1 receptor. AZD3778 exhibits anti-eosinophilic activity. AZD3778 alleviates symptoms associated with allergic rhinitis. AZD3778 can be used in research related to allergic rhinitis and asthma.

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No. CAS: 485391-80-8
Fòrmula: C₂₄H₂₉Cl₂N₃O₄S
Peso molecular:526.48

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZD3778 Chemical Structure

No. CAS: 485391-80-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

CCR3

8.1 nM (IC₅₀)

Human H₁ Receptor

40 nM (IC₅₀)

Ver todos los productos específicos de isoformas Histamine Receptor :

Ver todos los productos específicos de isoformas CCR :

In Vitro

AZD3778 is a CCR3 and histamine H1 receptor inhibitor, with IC₅₀ values of 8.1 nM and 40 nM against human targets, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 485391-80-8
Peso molecular 526.48
Fòrmula C₂₄H₂₉Cl₂N₃O₄S
SMILES

O=C(N1CCC(CC1)N2CCC(CC2)OC3=CC=C(C(Cl)=C3)Cl)NS(=O)(C4=CC=C(C)C=C4)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Pease, J.E., et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. In: Tschammer, N. (eds) Chemokines. Topics in Medicinal Chemistry, vol 14. Springer, Cham.

[2]. Bahl A, et al. The discovery of CCR3/H1 dual antagonists with reduced hERG risk. Bioorg Med Chem Lett. 2012;22(21):6688-6693. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
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AZD3778

Ver todos los productos específicos de isoformas Histamine Receptor

Ver todos los productos específicos de isoformas CCR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

AZD3778 Related Classifications

HY-182439 Related Classifications