Referencia número: HY-N2453

Convallatoxin

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties.

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Pureza: 99.72%
No. CAS: 508-75-8
Fòrmula: C₂₉H₄₂O₁₀
Peso molecular:550.64

Almacenamiento:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Convallatoxin Chemical Structure

No. CAS: 508-75-8

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Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas PPAR :

Ver todos los productos específicos de isoformas NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
1A9	ED₅₀	0.03 μg/mL Compound: 20	Cytotoxicity against human 1A9 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human 1A9 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 24582402]
A549	ED₅₀	0.0027 μg/mL Compound: 20	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 24582402]
Bel-7402	IC₅₀	0.05 μM Compound: 9	Cytotoxicity against human Bel7402 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human Bel7402 cells after 48 hrs by sulforhodamine B assay	[PMID: 17844995]
CAKI-1	ED₅₀	0.0031 μg/mL Compound: 20	Cytotoxicity against human CAKI-1 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human CAKI-1 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 24582402]
HCT-116	IC₅₀	<0.04 μM Compound: 1	Cytotoxicity against human HCT116 cells after 72 hrs by FMCA method Cytotoxicity against human HCT116 cells after 72 hrs by FMCA method	[PMID: 19894733]
HT-29	IC₅₀	0.55 μM Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by FMCA method Cytotoxicity against human HT-29 cells after 72 hrs by FMCA method	[PMID: 19894733]
KB	ED₅₀	0.014 μg/mL Compound: 20	Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 24582402]
MCF7	ED₅₀	0.0065 μg/mL Compound: 20	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 24582402]
PC-3	ED₅₀	0.094 μg/mL Compound: 20	Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 24582402]
SK-MEL-2	ED₅₀	0.0013 μg/mL Compound: 20	Cytotoxicity against human SK-MEL-2 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human SK-MEL-2 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 24582402]
U-251	EC₅₀	0.02 μM Compound: 11	Inhibition of HIF1 activation in human U251 cells stably transfected in pGL2-TK-HRE plasmid under hypoxic condition after 16 to 24 hrs by luciferase reporter gene assay Inhibition of HIF1 activation in human U251 cells stably transfected in pGL2-TK-HRE plasmid under hypoxic condition after 16 to 24 hrs by luciferase reporter gene assay	[PMID: 19405508]
U-87MG ATCC	ED₅₀	0.014 μg/mL Compound: 20	Cytotoxicity against human U87MG cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human U87MG cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 24582402]

In Vitro

Convallatoxin induces HaCaT cell necroptosis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Convallatoxin exerts antipsoriatic activities in two mouse models of psoriasis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 508-75-8
Appearance Solid
Peso molecular 550.64
Fòrmula C₂₉H₄₂O₁₀
Color White to off-white
SMILES

O=C1OCC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@]5(O)C[C@@H](O[C@H]6[C@@H]([C@@H]([C@H]([C@H](C)O6)O)O)O)CC[C@]5(C=O)[C@@]4([H])CC[C@]23C)=C1
Structure Classification
- Steroids
- Cardiacglycosides
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Naunyn Schmiedebergs Arch Pharmacol

Convallatoxin ameliorates fibroblast-like synoviocytes-mediated synovial inflammation and joint destruction in rheumatoid arthritis by targeting IDH1. [Abstract]

2026 Feb 6. PMID: 41644791

Solvente y solubilidad

In Vitro:

DMSO : 50 mg/mL (90.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8161 mL

9.0803 mL

18.1607 mL

5 mM

0.3632 mL

1.8161 mL

3.6321 mL

10 mM

0.1816 mL

0.9080 mL

1.8161 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (4.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (277 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Li MY, et al. Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ. Pharmacol Res. 2019 Sep;147:104355. [Content Brief]

[2]. Gozalpour E, et al. Convallatoxin: a new P-glycoprotein substrate. Eur J Pharmacol. 2014 Dec 5;744:18-27. [Content Brief]

[3]. Chao PK, et al. Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice. Sci Rep. 2019 Feb 20;9(1):2405. [Content Brief]

[4]. Jiang BW, et al. Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models. Biomed Pharmacother. 2020 Jan;121:109615. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8161 mL	9.0803 mL	18.1607 mL	45.4017 mL
	5 mM	0.3632 mL	1.8161 mL	3.6321 mL	9.0803 mL
	10 mM	0.1816 mL	0.9080 mL	1.8161 mL	4.5402 mL
	15 mM	0.1211 mL	0.6054 mL	1.2107 mL	3.0268 mL
	20 mM	0.0908 mL	0.4540 mL	0.9080 mL	2.2701 mL
	25 mM	0.0726 mL	0.3632 mL	0.7264 mL	1.8161 mL
	30 mM	0.0605 mL	0.3027 mL	0.6054 mL	1.5134 mL
	40 mM	0.0454 mL	0.2270 mL	0.4540 mL	1.1350 mL
	50 mM	0.0363 mL	0.1816 mL	0.3632 mL	0.9080 mL
	60 mM	0.0303 mL	0.1513 mL	0.3027 mL	0.7567 mL
	80 mM	0.0227 mL	0.1135 mL	0.2270 mL	0.5675 mL

Keywords

Convallatoxin

1 Cited Publications

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Convallatoxin

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Publications Citing Use of MedChemExpress (MCE) Convallatoxin

Ver todos los productos específicos de isoformas PPAR

Ver todos los productos específicos de isoformas NF-κB

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Convallatoxin Related Classifications

HY-N2453 Related Classifications