Lactic acid
Based on 64 publication(s) in Google Scholar
Lactic acid (DL-Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid also has antimicrobial activity, which can be used as a food preservative.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 85.12%
- No. CAS: 50-21-5
- Fòrmula: C3H6O3
- Peso molecular:90.08
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Lactic acid
More- Cell Res. 2023 Sep;33(9):679-698. [Abstract]
- Bioact Mater. 2024 Jun 24:40:445-459. [Abstract]
- Nat Commun. 2025 Dec 12. [Abstract]
- Nat Commun. 2025 Dec 19. [Abstract]
- J Adv Res. 2025 May 13:S2090-1232(25)00351-0. [Abstract]
- Redox Biol. 2025 Apr:81:103553. [Abstract]
- Acta Pharm Sin B. 2026 Feb.
- J Exp Clin Cancer Res. 2024 Mar 5;43(1):68. [Abstract]
- MedComm (2020). 2025 Aug 29;6(9):e70344. [Abstract]
- Adv Sci (Weinh). 2025 Jul 29:e09477. [Abstract]
- Adv Sci (Weinh). 2025 Mar 27:e2415530. [Abstract]
- Adv Sci (Weinh). 2025 Mar 27:e2413709. [Abstract]
- Adv Sci (Weinh). 2024 Dec;11(47):e2406184. [Abstract]
- Adv Sci (Weinh). 2024 May 20:e2307216. [Abstract]
- Cell Death Differ. 2025 Sep 23. [Abstract]
- Research (Wash D C). 2025 May 30:8:0705. [Abstract]
- Environ Sci Technol. 2025 Aug 5;59(30):15705-15719. [Abstract]
- Cell Death Dis. 2025 Mar 20;16(1):193. [Abstract]
- Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]
- Cancer Lett. 2026 Sep 28:656:218655. [Abstract]
- Int J Biol Sci. 2025 Apr 22;21(7):3061-3080. [Abstract]
- Phytomedicine. 2025 May:140:156628. [Abstract]
- Clin Cancer Res. 2026 Apr 17. [Abstract]
- J Transl Med. 2025 Aug 18;23(1):923. [Abstract]
- J Anim Sci Biotechnol. 2024 Jun 11;15(1):86. [Abstract]
- Stem Cell Res Ther. 2025 Oct 1;16(1):538. [Abstract]
- Cell Rep. 2026 Apr 27;45(5):117317. [Abstract]
- Cell Rep. 2025 Jul 30;44(8):116091. [Abstract]
- Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
- J Ginseng Res. 2024 May;48(3):298-309. [Abstract]
- J Agric Food Chem. 2026 Jun 24;74(24):18768-18778. [Abstract]
- J Agric Food Chem. 2025 Dec 17;73(50):32236-32249. [Abstract]
- Ecotoxicol Environ Saf. 2025 Nov 15:307:119451. [Abstract]
- Biochem Pharmacol. 2026 Mar 20:249:117918. [Abstract]
- RSC Adv. 2026 May 18;16(21):19511-19523. [Abstract]
- Cancer Metab. 2026 Apr 2;14(1):13. [Abstract]
- Commun Biol. 2025 Nov 20;8(1):1626. [Abstract]
- Commun Biol. 2025 Jul 8;8(1):1020. [Abstract]
- Cancer Immunol Immunother. 2024 Oct 3;73(12):254. [Abstract]
- Respir Res. 2024 Nov 9;25(1):401. [Abstract]
- Int Immunopharmacol. 2025 Apr 4:151:114269. [Abstract]
- Biol Direct. 2025 May 26;20(1):64. [Abstract]
- Sci Rep. 2026 May 25. [Abstract]
- Food Qual Saf. 2025 Aug 4.
- Cell Signal. 2026 Jun 27:112701. [Abstract]
- J Cell Mol Med. 2025 Jul;29(13):e70692. [Abstract]
- J Cell Mol Med. 2025 Jun;29(12):e70669. [Abstract]
- Brain Res Bull. 2025 May:224:111292. [Abstract]
- FASEB J. 2026 May 15;40(9):e71765. [Abstract]
- FASEB J. 2026 Feb 15;40(3):e71547. [Abstract]
- Neurotox Res. 2026 Apr 24;44(3):24. [Abstract]
- Ren Fail. 2026 Dec;48(1):2630507. [Abstract]
- Vet Res. 2025 Apr 30;56(1):94. [Abstract]
- J Integr Neurosci. 2025 Feb 25;24(2):25949. [Abstract]
- 3 Biotech. 2026 May;16(5):181. [Abstract]
- Exp Eye Res. 2026 Jun:267:110981. [Abstract]
- Kaohsiung J Med Sci. 2025 Nov 13:e70123. [Abstract]
- Tissue Cell. 2024 Jul 9:89:102468. [Abstract]
- J Cardiovasc Transl Res. 2025 Sep 8. [Abstract]
- Biochem Biophys Res Commun. 2025 Sep 8:778:152379. [Abstract]
- Genes Genomics. 2025 May;47(5):521-531. [Abstract]
- Res Sq. 2026 Jun 15.
- bioRxiv. 2026 Mar 10.
- Res Sq. 2026 Feb 19.
Customer Validation & Images
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Ver todos los productos específicos de isoformas Endogenous Metabolite
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Actividad biológica
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HCAR1 |
Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
26.6 μM
Compound: Lactic acid
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Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
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[PMID: 28710964] |
| A549 | IC50 |
26.61 mM
Compound: Lactic acid
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 25299679] |
| MRC5 | IC50 |
23.93 mM
Compound: Lactic acid
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 25299679] |
| MRC5 | IC50 |
23.93 μM
Compound: Lactic acid
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Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay
Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay
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[PMID: 28710964] |
Lactic acid (20 mM; 24, 48 h) results in a significant decrease in cell proliferation and migration, acting and switching cell metabolism toward oxidative phosphorylation[1].
Lactic acid (20 mM; 24 h) shows an increase in the protein and mRNA expression levels of MCT1 and HCAR1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Uveal melanoma 92.1 cells
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Concentration:20 mM
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Incubation Time:24, 48 h
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Result:Inhibited cell proliferation and migration.
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Cell Line:Uveal melanoma cells
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Concentration:20 mM
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Incubation Time:24 h
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Result:Showed an increase in the protein expression levels of MCT1 and HCAR1
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Cell Line:Uveal melanoma cells
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Concentration:20 mM
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Incubation Time:24 h
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Result:Induced a significant increase in mRNA expression levels of SLC16A1 and HCAR1.
Note: The pH of the working solution needs to be adjusted to around 7.4 before administration to animals.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C57BL/6 mice with MC38 colon cancer cells[2]
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Dosage:1.6 g/kg
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Administration:Subcutaneous; daily from Day 8 to 30 days
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Result:Significantly suppressed tumor growth.
Chemical Information
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No. CAS 50-21-5
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Appearance Liquid (Density: 1.209 g/cm3)
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Peso molecular 90.08
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Fòrmula C3H6O3
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Color Colorless to light yellow
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SMILES
CC(O)C(O)=O
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Synonyms
DL-Lactic acid; E-270
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (64)
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Journal Impact Factor
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Most Recent
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Cell Res
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure. [Abstract]2023 Sep;33(9):679-698. PMID: 37443257
Lactic acid purchased from MedChemExpress. Usage Cited in: Cell Res. 2023 Sep;33(9):679-698. [Abstract]
Lactate (NALA) (300 mM; 24 h) significantly upregulates α-MHC K1897 lactylation in H9c2 cells.
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Bioact Mater
Concerting magnesium implant degradation facilitates local chemotherapy in tumor-associated bone defect. [Abstract]2024 Jun 24:40:445-459. PMID: 39027327 -
Nat Commun
Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation. [Abstract]2025 Dec 12. PMID: 41387463 -
Nat Commun
IDH2 lactylation promotes angiogenesis in murine diabetic myocardial infarction via blocking Cav1-eNOS interaction. [Abstract]2025 Dec 19. PMID: 41419771 -
J Adv Res
Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis. [Abstract]2025 May 13:S2090-1232(25)00351-0. PMID: 40373963 -
Redox Biol
Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation. [Abstract]2025 Apr:81:103553. PMID: 39970777
Lactic acid purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Apr:81:103553. [Abstract]
Immunoblot and quantification analyses of NFS1 in HCC cells incubated with 0, 5, or 10 mM lactate after being subjected to either a 47 °C or 37 °C water bath.
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J Exp Clin Cancer Res
MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis. [Abstract]2024 Mar 5;43(1):68. PMID: 38439082
Lactic acid purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 Mar 5;43(1):68. [Abstract]
Lactate sodium increases IGF-1R levels in PI-resistant KAS-6/1 and U266 cells.
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MedComm (2020)
Global Lactylome Reveals Lactylation-Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome. [Abstract]2025 Aug 29;6(9):e70344. PMID: 40895187 -
Adv Sci (Weinh)
ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma. [Abstract]2025 Jul 29:e09477. PMID: 40726441
Lactic acid purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 29:e09477. [Abstract]
Following the direct addition of lactic acid (a final concentration of 100 mM) to the culture medium for 12 h, western blotting, and immunoprecipitation assays revealed a significant increase in the total lactylation and corresponding lysine-312 lactylation levels in ASH2L
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Adv Sci (Weinh)
High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1. [Abstract]2025 Mar 27:e2415530. PMID: 40145796 -
Adv Sci (Weinh)
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling. [Abstract]2025 Mar 27:e2413709. PMID: 40150862
Lactic acid purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar 27:e2413709. [Abstract]
Western blot of UGDH lactylation in chondrocytes with Lactic acid sodium (lactate) (25 mM) treatment for 24 h.
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Adv Sci (Weinh)
PKM2-Driven Lactate Overproduction Triggers Endothelial-To-Mesenchymal Transition in Ischemic Flap via Mediating TWIST1 Lactylation. [Abstract]2024 Dec;11(47):e2406184. PMID: 39474980 -
Adv Sci (Weinh)
Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury. [Abstract]2024 May 20:e2307216. PMID: 38767134 -
Cell Death Differ
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy. [Abstract]2025 Sep 23. PMID: 40987895 -
Research (Wash D C)
Lactate-Induced Mitochondrial Calcium Uptake 3 Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Neutrophil Extracellular Trap Formation. [Abstract]2025 May 30:8:0705. PMID: 40452820 -
Environ Sci Technol
Chronic Dietary Exposure to Environmental Levels of Glyphosate Increases the Risk of Reproductive Dysfunction in Male Mice. [Abstract]2025 Aug 5;59(30):15705-15719. PMID: 40698942 -
Cell Death Dis
Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis. [Abstract]2025 Mar 20;16(1):193. PMID: 40113760
Lactic acid purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Mar 20;16(1):193. [Abstract]
Lactate sodium (5-15 mM; 24 h) results in increased H4K12la (red) levels in CCSCs compared to the control group.
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Cell Death Dis
Lactylation-driven transcriptional activation of FBXO33 promotes gallbladder cancer metastasis by regulating p53 polyubiquitination. [Abstract]2025 Feb 28;16(1):144. PMID: 40021626
Lactic acid purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]
Lactate (25 mM) significantly increases the mRNA and protein expression of FBXO33.
Lactic acid purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]
Co-IP detected the effect of lactate on YY1 protein lactylation modification.
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Cancer Lett
Targeting C/EBPβ/SCD1/C16:1 loop-driven macrophage M2 polarization by Bruceine D improves anti-PD-1 immunotherapy in colorectal cancer. [Abstract]2026 Sep 28:656:218655. PMID: 42250753 -
Int J Biol Sci
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation. [Abstract]2025 Apr 22;21(7):3061-3080. PMID: 40384874 -
Phytomedicine
Effective-compounds of Jinshui Huanxian Formula acts as an SRC inhibitor to inhibit HK2-mediated H3K18 lactation and improve pulmonary fibrosis. [Abstract]2025 May:140:156628. PMID: 40090047 -
Clin Cancer Res
Lactate-induced lactylation enhances BMAL1 transcription and nuclear translocation, promoting bevacizumab resistance in glioblastoma through VEGFA. [Abstract]2026 Apr 17. PMID: 41995718 -
J Transl Med
Metabolic interplay between endometrial cancer and tumor-associated macrophages: lactate-induced M2 polarization enhances tumor progression. [Abstract]2025 Aug 18;23(1):923. PMID: 40826409 -
J Anim Sci Biotechnol
The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation. [Abstract]2024 Jun 11;15(1):86. PMID: 38858724 -
Stem Cell Res Ther
H3K18 lactylation-hexokinase 2 positive feedback loop promotes osteogenesis of ASPCs in facial infiltrating lipomatosis. [Abstract]2025 Oct 1;16(1):538. PMID: 41035068 -
Cell Rep
Heat shock protein 90β lactylation acts as a metabolic switch to drive cerebrovascular apoptosis under heat stress. [Abstract]2026 Apr 27;45(5):117317. PMID: 42048184 -
Cell Rep
TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease. [Abstract]2025 Jul 30;44(8):116091. PMID: 40748757 -
Cell Rep
High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy. [Abstract]2025 Apr 9;44(4):115545. PMID: 40215164 -
J Ginseng Res
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3. [Abstract]2024 May;48(3):298-309. PMID: 38707638
Lactic acid purchased from MedChemExpress. Usage Cited in: J Ginseng Res. 2024 May;48(3):298-309. [Abstract]
The expression level of METTL3, YTHDF1, YTHDF2, and YTHDC1 in NB4-R1 and NB4-R2 cells treated with 20 μM oxamate or 20 μM lactate or 1 μM ATRA for 48 h was detected via qRT-PCR.
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J Agric Food Chem
Dietary Lactic Acid Attenuates Ovalbumin-Induced Food Allergy in Mice via Orchestrating Dendritic Cell and T Cell Immune Tolerance. [Abstract]2026 Jun 24;74(24):18768-18778. PMID: 42287222 -
J Agric Food Chem
Lactic Acid Alleviates Cow's Milk Allergy by Regulating Regulatory T Cells and Intestinal Microbiota. [Abstract]2025 Dec 17;73(50):32236-32249. PMID: 41359930 -
Ecotoxicol Environ Saf
MC-LR triggers trophoblast ferroptosis at the maternal-fetal interface by directly targeting PKM2 to reprogram metabolism. [Abstract]2025 Nov 15:307:119451. PMID: 41273830 -
Biochem Pharmacol
CSDE1-mediated histone lactylation modification of the HOXD9 promoter promotes gastric cancer progression. [Abstract]2026 Mar 20:249:117918. PMID: 41864431 -
RSC Adv
Inducible secretion of LIGHT by engineered probiotics enables localized cytokine therapy and robust antitumor immunity. [Abstract]2026 May 18;16(21):19511-19523. PMID: 42157872 -
Cancer Metab
PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid-derived suppressor cells. [Abstract]2026 Apr 2;14(1):13. PMID: 41928364 -
Commun Biol
Deoxynivalenol induces ferroptosis via inhibiting glycolysis-H3K18la-STEAP3 axis to promote ovary damage in piglets. [Abstract]2025 Nov 20;8(1):1626. PMID: 41266595 -
Commun Biol
CAF-derived GLUT1 and its role in modulating ovarian cancer progression: a multi-dimensional analysis of the tumor microenvironment. [Abstract]2025 Jul 8;8(1):1020. PMID: 40629043 -
Cancer Immunol Immunother
2024 Oct 3;73(12):254. PMID: 39358478 -
Respir Res
Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis. [Abstract]2024 Nov 9;25(1):401. PMID: 39522031 -
Int Immunopharmacol
Histone lactylation protects against sevoflurane-induced cognitive impairment by regulating YTHDF3/PRDX3 mediated microglial pyroptosis in neonatal mice. [Abstract]2025 Apr 4:151:114269. PMID: 40022822 -
Biol Direct
LDHA-mediated YAP lactylation promotes the tumor progression of hepatocellular carcinoma by inducing YAP dephosphorylation and activation. [Abstract]2025 May 26;20(1):64. PMID: 40414964 -
Sci Rep
Integrating single-cell and bulk transcriptomic analyses to explore key lactylation-related genes in benign prostatic hyperplasia. [Abstract]2026 May 25. PMID: 42185567 -
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Cell Signal
PDK4-dependent lactate production and lactylation promote renal calcium oxalate crystal-induced EMT and mitochondrial dysfunction via the TGF-β/SMAD3/GPX4 axis. [Abstract]2026 Jun 27:112701. PMID: 42364861 -
J Cell Mol Med
Identification of LDHA as a Potential Therapeutic Target for Pulmonary Hypertension Through Modulation of Endothelial-To-Mesenchymal Transition. [Abstract]2025 Jul;29(13):e70692. PMID: 40629253 -
J Cell Mol Med
Lactylation-Related Gene LILRB4 Predicts the Prognosis and Immunotherapy of Prostate Cancer Based on Machine Learning. [Abstract]2025 Jun;29(12):e70669. PMID: 40576161 -
Brain Res Bull
LDHA enhances brain injury and apoptosis after intracerebral hemorrhage by promoting P53 transcription through increasing P53 lactylation. [Abstract]2025 May:224:111292. PMID: 40057050 -
FASEB J
Lactate-Driven Epigenetic Reprogramming of Osteogenesis: H3K18 Lactylation Activates m6A/YTHDF1-Dependent YAP1 Signaling to Combat Bone Loss. [Abstract]2026 May 15;40(9):e71765. PMID: 42033168 -
FASEB J
Limonin Is a Novel Hexokinase 2 Inhibitor That Suppresses Hepatic Stellate Cell Activation and Histone Lactylation. [Abstract]2026 Feb 15;40(3):e71547. PMID: 41649270 -
Neurotox Res
TDP-43 Dysfunction Causes Hyper-Lactate State, Increased AARS1 Expression and Enhanced Protein Lactylation. [Abstract]2026 Apr 24;44(3):24. PMID: 42029805 -
Ren Fail
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation. [Abstract]2026 Dec;48(1):2630507. PMID: 41808346 -
Vet Res
Neospora caninum hijacks host PFKFB3-driven glycolysis to facilitate intracellular propagation of parasites. [Abstract]2025 Apr 30;56(1):94. PMID: 40307939 -
J Integr Neurosci
2025 Feb 25;24(2):25949. PMID: 40018779 -
3 Biotech
Touxie Quyin Compound regulates histone lactylation-mediated Fabp4/5 and tissue-resident memory T cells to improve psoriasis recurrence in mice. [Abstract]2026 May;16(5):181. PMID: 42077602 -
Exp Eye Res
Aqueous humor levels of H3K18 lactylation and IL-1β reflect epigenetic-inflammatory activation in lens epithelium and serve as novel potential biomarkers for cataract diagnosis. [Abstract]2026 Jun:267:110981. PMID: 41864487 -
Kaohsiung J Med Sci
Hypoxia-Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β-Catenin Pathway. [Abstract]2025 Nov 13:e70123. PMID: 41229334 -
Tissue Cell
Gegen Qinlian decoction inhibited M1 macrophage polarization and ulcerative colitis progression through regulating histone lactylation. [Abstract]2024 Jul 9:89:102468. PMID: 39003913 -
J Cardiovasc Transl Res
Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation. [Abstract]2025 Sep 8. PMID: 40920282 -
Biochem Biophys Res Commun
Hsp60 lactylation promotes mitochondrial dysfunction and trophoblast apoptosis in preeclampsia. [Abstract]2025 Sep 8:778:152379. PMID: 40694902 -
Genes Genomics
Lactate released by lung adenocarcinoma (LUAD) cells promotes M2 macrophage polarization via the GPR132/cAMP/PKA pathway. [Abstract]2025 May;47(5):521-531. PMID: 40053234 -
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Solvente y solubilidad
H2O : ≥ 200 mg/mL (2220.25 mM)
DMSO : ≥ 200 mg/mL (2220.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (55.51 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (55.51 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24(1):24. [Content Brief]
[2]. Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13(1):4981. [Content Brief]
[3]. Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18(5):566-575. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 11.1012 mL | 55.5062 mL | 111.0124 mL | 277.5311 mL |
| 5 mM | 2.2202 mL | 11.1012 mL | 22.2025 mL | 55.5062 mL | |
| 10 mM | 1.1101 mL | 5.5506 mL | 11.1012 mL | 27.7531 mL | |
| 15 mM | 0.7401 mL | 3.7004 mL | 7.4008 mL | 18.5021 mL | |
| 20 mM | 0.5551 mL | 2.7753 mL | 5.5506 mL | 13.8766 mL | |
| 25 mM | 0.4440 mL | 2.2202 mL | 4.4405 mL | 11.1012 mL | |
| 30 mM | 0.3700 mL | 1.8502 mL | 3.7004 mL | 9.2510 mL | |
| 40 mM | 0.2775 mL | 1.3877 mL | 2.7753 mL | 6.9383 mL | |
| 50 mM | 0.2220 mL | 1.1101 mL | 2.2202 mL | 5.5506 mL | |
| 60 mM | 0.1850 mL | 0.9251 mL | 1.8502 mL | 4.6255 mL | |
| 80 mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 3.4691 mL | |
| 100 mM | 0.1110 mL | 0.5551 mL | 1.1101 mL | 2.7753 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lactic acid Related Classifications
HY-B2227 Related Classifications
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- Lactic acid
- 50-21-5
- DL-Lactic acid
- E-270
- E270
- E 270
- E-270
- Environmental Pollutants
- Hydroxycarboxylic Acid Receptor (HCAR)
- Bacterial
- Endogenous Metabolite
- hydroxycarboxylic acid receptor 1
- HCAR1
- epigenetic
- lysine residues lactylation
- glycolysis
- oxidative phosphorylation
- oncometabolite
- anti-tumor
- Inhibitor
- inhibitor
- inhibit