Leronlimab
Based on 1 Customer Validation
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.91%
- No. CAS: 674782-26-4
- Peso molecular:146.7 kDa
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Human IgG4 kappa
Human
CCR5/CD195
Leronlimab (1-140 mg/mL) binds to CCR5-positive cells up to 98%[1]. Leronlimab (80-1750 μg/mL) blocks CCL5, CCL3, and CCL4-induced calcium responses in MDA-MB-231-CCR5 cells[1]. Leronlimab (175 and 350 mg/mL) blocks MDA-MB-231 cell invasion[1]. Leronlimab (10 μg/mL; 72 hours) enhances the cytotoxicity of doxorubicin for MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231 cell line
-
Concentration:10 μg/mL
-
Incubation Time:72 hours
-
Result:Increased the cells killing effect induced by doxorubicin.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female NCI Athymic nu/nu nude mice with MB-MDA-231 cells expressing Luc2-eGFP injection[1]
-
Dosage:2 mg
-
Administration:Intraperitoneal injection; 2 mg, twice a week
-
Result:Reduced the volume of pulmonary metastases at 8 weeks.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG4 kappa
ELISA, FACS, Functional assay
-
Flow cytometric analysis of 1.5×106 THP-1 cells with Leronlimab (HY-P99697, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
-
No. CAS 674782-26-4
-
Appearance Liquid
-
Peso molecular 146.7 kDa
-
Color Colorless to light yellow
-
SMILES
[Leronlimab]
-
Synonyms
PRO 140
-
Envío
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
-
Ficha de datos (259 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leronlimab Related Classifications
HY-P99697 Related Classifications
Powered by Bioz