MC4491
MC4491 is a selective LSD1/PRMT5 inhibitor, with an IC50 of 0.152 μM against the LSD1/CoREST complex and an IC50 of 0.043 μM against the PRMT5/MEP50 complex. MC4491 induces transcriptomic changes and splicing alterations in AML cells. MC4491 is applicable for the research of acute myeloid leukemia.
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- Fòrmula: C35H45N7O3
- Peso molecular:611.78
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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LSD1 0.152 μM (IC50) |
PRMT5 0.043 μM (IC50) |
MC4491 potently and selectively inhibits both LSD1/CoREST (IC50 = 0.152 μM) and PRMT5/MEP50 (IC50 = 0.043 nM) in biochemical assays, with minimal activity against PRMT1 and PRMT7[1].
MC4491 (50 nM; 3 days) treatment of MV4-11 AML cells recapitulates the transcriptomic and alternative splicing changes induced by combined PRMT5 and LSD1 inhibition, including activation of myeloid differentiation pathways and suppression of cell cycle-related pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 611.78
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Fòrmula C35H45N7O3
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SMILES
NC1CC1C2=CC=C(C=C2)NC(CCN3CCC(CC3)NC4=CC(C(NC[C@@H](CN5CCC6=CC=CC=C6C5)O)=O)=CC=N4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MC4491 Related Classifications
HY-182892 Related Classifications
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