Nemonapride
Based on 1 Customer Validation
Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.
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- Pureza : 99.9%
- No. CAS: 75272-39-8
- Fòrmula: C21H26ClN3O2
- Peso molecular:387.90
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas Dopamine Receptor
MoreVer todos los productos específicos de isoformas 5-HT Receptor
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Actividad biológica
Descripciòn
IC50 & Target
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5-HT1A Receptor 34 nM (IC50) |
5-HT1A Receptor |
D2 Receptor 0.06 nM (Ki) |
Chemical Information
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No. CAS 75272-39-8
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Appearance Solid
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Peso molecular 387.90
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Fòrmula C21H26ClN3O2
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Color White to off-white
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SMILES
O=C(N[C@H]1[C@@H](C)N(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(NC)C=C3OC
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Synonyms
YM-09151-2; Emonapride
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMF : 20 mg/mL (51.56 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Terai M, et al. Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn J Pharmacol. 1983 Aug;33(4):749-55. [Content Brief]
[2]. Seeman P, Van Tol HH. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. [Content Brief]
[3]. Assié MB, et al. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. Eur J Pharmacol. 1997 Sep 10;334(2-3):141-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.5780 mL | 12.8899 mL | 25.7798 mL | 64.4496 mL |
| 5 mM | 0.5156 mL | 2.5780 mL | 5.1560 mL | 12.8899 mL | |
| 10 mM | 0.2578 mL | 1.2890 mL | 2.5780 mL | 6.4450 mL | |
| 15 mM | 0.1719 mL | 0.8593 mL | 1.7187 mL | 4.2966 mL | |
| 20 mM | 0.1289 mL | 0.6445 mL | 1.2890 mL | 3.2225 mL | |
| 25 mM | 0.1031 mL | 0.5156 mL | 1.0312 mL | 2.5780 mL | |
| 30 mM | 0.0859 mL | 0.4297 mL | 0.8593 mL | 2.1483 mL | |
| 40 mM | 0.0644 mL | 0.3222 mL | 0.6445 mL | 1.6112 mL | |
| 50 mM | 0.0516 mL | 0.2578 mL | 0.5156 mL | 1.2890 mL |
Nemonapride Related Classifications
HY-103415 Related Classifications
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