Plumericin
Plumericin is an anti-inflammatory, antioxidant, and antibacterial agent. Plumericin reduces Apoptosis, promotes Nrf-2 and inhibits NF-κB and AhR activation, blocks STAT3 signaling. Plumericin inhibits Mycobacterium tuberculosis growth. Plumericin can be used for the research of chronic kidney disease, vascular diseases, inflammatory bowel diseases, peritonitis, and tuberculosis.
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- No. CAS: 77-16-7
- Fòrmula: C15H14O6
- Peso molecular:290.27
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
STAT3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Cancer cell lines | ED50 |
0.1 μg/mL
Compound: 5
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Cytotoxicity against human colon cancer cells
Cytotoxicity against human colon cancer cells
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[PMID: 1965200] |
In Vitro
Plumericin (0.5-2 μM; 1 h pre-incubation, then 24 h co-incubation with IS) significantly reduces IS-induced apoptosis, decreases Bax expression, and increases Bcl-2 expression in IEC-6 cells[1].
Plumericin (0.5-2 μM; 1 h pre-incubation, then 24 h co-incubation with IS) significantly inhibits IS-induced expression of iNOS, COX-2, and caspase-1, as well as IL-1β production, in IEC-6 cells[1].
Plumericin (0.3-3 μM; 30 min pre-incubation, 24 h serum-stimulated) inhibits serum-induced proliferation of primary rat aortic VSMC with an IC50 of 1.11 μM, as measured by BrdU incorporation following 30 min pre-incubation and 24 h serum stimulation[2].
Plumericin (0.5-2 μM; 24 h) does not reduce proliferation of rat intestinal epithelial IEC-6 cells[3].
Plumericin (0.3-10 μM; 30 min pretreatment + 4 h incubation) potently inhibits TNF-α-induced and constitutively active IKK-β-induced NF-κB pathway activation in HEK293/NF-κB-luc cells, with an IC50 of 1.07 μM for TNF-α-induced transactivation, and does not alter basal NF-κB activity[4].
Plumericin (0.5-2 μM; 24 h) significantly increases migration speed in LPS + IFN-stimulated IEC-6 cells, promoting intestinal epithelial wound restitution[5].
Plumericin (serial dilutions; 5 days for MIC, 6 weeks for MBC) inhibits the growth of pan-sensitive Mycobacterium tuberculosis H37Rv with an MIC of 2.1 ± 0.12 μg/mL and reduces viable bacterial counts by ≥99% at an MBC of 3.6 ± 0.22 μg/mL[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IEC-6 rat intestinal epithelial cells
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Concentration:0.5-2 μM
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Incubation Time:1 h pre-incubation, then 24 h co-incubation with IS
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Result:Significantly reduced IS-induced apoptosis at all tested concentrations.
Significantly decreased pro-apoptotic Bax expression at all tested concentrations compared to IS-only treated cells.
Significantly increased anti-apoptotic Bcl-2 expression at all tested concentrations compared to IS-only treated cells.
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Cell Line:IEC-6 rat intestinal epithelial cells
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Concentration:1 μM
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Incubation Time:1 h before IS
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Result:Significantly reduced IS-induced nuclear translocation of NF-κB p65, decreasing nuclear NF-κB p65 fluorescence intensity compared to IS-only treated cells.
In Vivo
Plumericin (3 mg/kg; i.p.; twice) statistically significantly reduces thioglycollate-induced neutrophil recruitment to the peritoneal cavity of mice (P < 0.001)[4].
Plumericin (3 mg/kg; i.p.; once daily; 4 days) significantly alleviates colonic inflammation, PARP activation, and apoptotic damage in DNBS-induced mouse colitis models[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 mice (male, 20-25 g, DNBS-induced colitis)[3]
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Dosage:3 mg/kg
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Administration:i.p.; daily; 4 days
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Result:Significantly reduced body weight loss compared to DNBS-only mice.
Prevented colon shortening relative to DNBS-only mice.
Significantly reduced macroscopic colon damage scores.
Reduced histological signs of colon injury, including decreased cellular infiltration, edema, and inflammatory lesions.
Significantly reduced colon TNF-α levels (P < .001 vs DNBS group).
Inhibited DNBS-induced IκB-α degradation and NF-κB p65 nuclear translocation.
Significantly reduced colon malondialdehyde (MDA) levels (P < .001 vs DNBS group).
Reduced nitrotyrosine immunoreactivity in colon tissue (P < .001 vs DNBS group).
Significantly increased colon Nrf2 and superoxide dismutase (SOD) expression.
Significantly reduced colon IL-1β levels (P < .001 vs DNBS group).
Reduced colon caspase-1 expression.
Chemical Information
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No. CAS 77-16-7
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Peso molecular 290.27
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Fòrmula C15H14O6
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SMILES
C(\C)=C/1\[C@]2([C@]3([C@@]4([C@](C=C3)(C(C(OC)=O)=CO[C@@]4(O2)[H])[H])[H])OC1=O)[H]
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Rispoli RM, et al. Plumericin Modulates the AhR-NFκB-Nrf2 Signaling Network to Counteract Indoxyl Sulfate-Induced Intestinal Epithelial Cells Impairment. Int J Mol Sci. 2025;27(1):293. Published 2025 Dec 27. [Content Brief]
[2]. Heiss EH, et al. Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation. Sci Rep. 2016;6:20771. Published 2016 Feb 9. [Content Brief]
[3]. Rapa SF, et al. Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo. FASEB J. 2020;34(1):1576-1590. [Content Brief]
[4]. Fakhrudin N, et al. Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. Br J Pharmacol. 2014;171(7):1676-1686. [Content Brief]
[5]. Rapa SF, et al. Plumericin Protects against Experimental Inflammatory Bowel Disease by Restoring Intestinal Barrier Function and Reducing Apoptosis. Biomedicines. 2021;9(1):67. Published 2021 Jan 12. [Content Brief]
[6]. Kumar P, et al. Anti-mycobacterial activity of plumericin and isoplumericin against MDR Mycobacterium tuberculosis. Pulm Pharmacol Ther. 2013;26(3):332-335. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Plumericin Related Classifications
HY-N16435 Related Classifications
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