SAHA-OH
SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis.
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- No. CAS: 2857098-30-5
- Fòrmula: C15H22N2O4
- Peso molecular:294.35
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Actividad biológica
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HDAC6 23 nM (IC50) |
HDAC1 237 nM (IC50) |
HDAC3 359 nM (IC50) |
HDAC2 399 nM (IC50) |
HDAC8 1070 nM (IC50) |
SAHA-OH (0.67-10.76 μM; 51 h) shows inhibition in bone marrow macrophages[1].
SAHA-OH (0.01 μM; 3 h) treatment in BMMØs (bone marrow macrophages) reduces IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2) and GROα (CXCL1) secretions[1].
SAHA-OH (10 μM; 4 or 9 h) treatment induces acetylation of cytoplasmic α-tubulin and nuclear histone H3[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates macrophage apoptosis[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates B cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BMMØs (bone marrow macrophages)
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Concentration:0.67-10.76 μM
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Incubation Time:51 h
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Result:Showed IC50 value in unstimulated BMMØs of 1.26 μM, and showed IC50 value in LPS-stimulated BMMØs of 10.76 μM.
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Cell Line:BMMØs (bone marrow macrophages)
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Concentration:0-30 μM
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Incubation Time:3 h
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Result:Resulted in a 24- to 26-fold increase in cellular viability as compared to the SAHA treatment.
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Cell Line:B cells
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Concentration:0-30 μM
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Incubation Time:3 h
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Result:Resulted in a 5-fold enhancement in viability and a 3-fold decrease in cell death for the B cell population.
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Cell Line:BMMØs (bone marrow macrophages)
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Concentration:10 μM
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Incubation Time:4 or 9 h
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Result:Resulted in the acetylation of α-tubulin.
Induced the acetylation of histone H3 compared to no treatment (NT).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-induced endotoxemia mouse model[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection; 50 mg/kg; once
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Result:Reduced proinflammatory cytokine secretions by about 50% compared to no treatment (NT) control mice.
Showed similar architecture as no treatment (NT) control and displayed well-organized lymphoid follicles.
Chemical Information
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No. CAS 2857098-30-5
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Peso molecular 294.35
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Fòrmula C15H22N2O4
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SMILES
O=C(NO)CCCCCCC(NC1=CC=C(CO)C=C1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SAHA-OH Related Classifications
HY-151569 Related Classifications
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