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Referencia número: HY-155960

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SH491

SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC₅₀: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9).

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No. CAS: 2975285-28-8
Fòrmula: C₃₃H₅₀N₂O
Peso molecular:490.76

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SH491 Chemical Structure

No. CAS: 2975285-28-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
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Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Cathepsin :

Ver todos los productos específicos de isoformas MMP :

Cellular Effect

Cell Line	Type	Value	Description	References
BMMC	IC₅₀	10.3 nM Compound: 33; SH491	Anti-osteoclastogenic activity in C57/BL6 mouse BMMC cells assessed as inhibition of RANKL-induced osteoclast differentiation incubated for 5 to 7 days in presence of M-CSF by TRAP staining based microscopic analysis relative to control Anti-osteoclastogenic activity in C57/BL6 mouse BMMC cells assessed as inhibition of RANKL-induced osteoclast differentiation incubated for 5 to 7 days in presence of M-CSF by TRAP staining based microscopic analysis relative to control	[PMID: 37597216]

Chemical Information

No. CAS 2975285-28-8
Peso molecular 490.76
Fòrmula C₃₃H₅₀N₂O
SMILES

C[C@]12[C@]([H])(C(C)(C)C3=C(C2)C=NC(C)=N3)CC[C@@]4([C@@]1(C[C@H]([C@]5([C@]4(CC[C@@H]5C(CC/C=C(C)\C)=C)C)[H])O)[H])C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang SJ, et al. Synthesis and Biological Evaluation of Heterocyclic Ring-Fused 20(S)-Protopanaxadiol Derivatives as Potent Antiosteoporosis Agents. J Med Chem. 2023 Aug 19. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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SH491

Ver todos los productos específicos de isoformas Cathepsin

Ver todos los productos específicos de isoformas MMP

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SH491 Related Classifications

HY-155960 Related Classifications