SH491
SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC50: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2975285-28-8
- Fòrmula: C33H50N2O
- Peso molecular:490.76
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Cathepsin
More
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BMMC | IC50 |
10.3 nM
Compound: 33; SH491
|
Anti-osteoclastogenic activity in C57/BL6 mouse BMMC cells assessed as inhibition of RANKL-induced osteoclast differentiation incubated for 5 to 7 days in presence of M-CSF by TRAP staining based microscopic analysis relative to control
Anti-osteoclastogenic activity in C57/BL6 mouse BMMC cells assessed as inhibition of RANKL-induced osteoclast differentiation incubated for 5 to 7 days in presence of M-CSF by TRAP staining based microscopic analysis relative to control
|
[PMID: 37597216] |
Chemical Information
-
No. CAS 2975285-28-8
-
Peso molecular 490.76
-
Fòrmula C33H50N2O
-
SMILES
C[C@]12[C@]([H])(C(C)(C)C3=C(C2)C=NC(C)=N3)CC[C@@]4([C@@]1(C[C@H]([C@]5([C@]4(CC[C@@H]5C(CC/C=C(C)\C)=C)C)[H])O)[H])C
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SH491 Related Classifications
HY-155960 Related Classifications
Powered by Bioz