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Referencia número: HY-160962

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SM1044

SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC₅₀ < 3.6 μM . SM1044 inhbits tumor growth in RL95-2 xenograft mouse model.

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No. CAS: 1331880-08-0
Fòrmula: C₃₄H₅₅NO₁₀
Peso molecular:637.80

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SM1044 Chemical Structure

No. CAS: 1331880-08-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Caspase :

Cellular Effect

Cell Line	Type	Value	Description	References
AN3-CA	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1-A	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1B cell line	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
KLE	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
RL95-2	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]

Chemical Information

No. CAS 1331880-08-0
Peso molecular 637.80
Fòrmula C₃₄H₅₅NO₁₀
SMILES

C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@@H]1OCCNCCO[C@@H]5[C@@H]([C@@]6([H])[C@]78[C@](O[C@](OO7)(CC[C@@]8([H])[C@@H](CC6)C)C)([H])O5)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhu Y, et al., Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite. Sci Rep. 2019 Oct 29;9(1):15528. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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Chemical Information
Pureza y Documentación
Referencias

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SM1044

Ver todos los productos específicos de isoformas Caspase