Solaprubart
Based on 1 Customer Validation
Solaprubart (STAR-0310) is a fully human IgG1 subtype monoclonal antibody targeting OX40 (CD134/TNFRSF4), with a Kd of 7.2 nM. By blocking the OX40/OX40L co-stimulatory signal, Solaprubart effectively inhibits cytokine release (IFN-γ, TNF-α, IL-5, IL-13) from activated effector T cells (Th1/Th2/Th17-associated). Solaprubart can be used in research related to moderate-to-severe atopic dermatitis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.59%
- No. CAS: 3057433-10-7
- Peso molecular:145.347 kDa
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Orexin Receptor (OX Receptor)
MoreVer todos los productos específicos de isoformas TNF Receptor
More
Actividad biológica
Descripciòn
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
OX40L |
IL-13 |
IL-6 |
In Vitro
Solaprubart (0.1-1000 nM) potently inhibits the release of IFNγ, TNF-α, IL-5 and IL-13 from pre-activated human T cells, with EC50 values of 11.8, 4.2, 16.4 and 5.3 nM, respectively[1].
Solaprubart (0-100 nM) significantly reduces ADCC activity against activated human T cells and regulatory human T cells, with EC50 values of 0.1 nM and 2.31 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Target
TNFRSF4/OX40/CD134
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
IgG1-kappa
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
-
Immobilized OX40/TNFRSF4 Protein, Human (HEK293, HY-P78189) can bind Solaprubart, The ED50 for this effect is 19.11 ng/mL.
Chemical Information
-
No. CAS 3057433-10-7
-
Appearance Liquid
-
Peso molecular 145.347 kDa
-
Color Colorless to light yellow
-
SMILES
[Solaprubart]
-
Synonyms
STAR-0310
-
Envío
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
-
Ficha de datos (257 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Solaprubart Related Classifications
HY-P992132 Related Classifications
Powered by Bioz