Thyrotropin
Based on 1 publication(s) in Google Scholar
Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism.
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- No. CAS: 9002-71-5
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Publications Citing Use of MedChemExpress (MCE) Thyrotropin
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Actividad biológica
Thyrotropin (rhTSH, 0.1-10 nM, 2-3 weeks) enhances human T-cell development[8].
Thyrotropin (bovine thyrotropin, 100 milliunits per mL, the first 24 to 48 h after trypsinization) develops follicle-like structures in dog, human, and bovine thyroid cells[10].
Thyrotropin (1 nM) promotes proliferation of FRTL-5 cells[11].
Thyrotropin regulates thyroid cell proliferation and differentiation[12].
Thyrotropin (10 mU/mL, up to 72 h) prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells[13].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FRTL-5
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Concentration:10 mU/mL
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Incubation Time:up to 72 h
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Result:Maintained the viability of FRTL-5 cells during the first 48 h.
Showed apparent increase in cell viability at 72 h.
Thyrotropin (i.p.) stimulates thyroid hormone into the circulation in wild-type and heterozygous mice[6].
Thyrotropin (rhTSH, 0.1 μg/g, i.p.) more readily replaces endogenous TSH in mice than in rat thyroid TSH receptors[7].
Thyrotropin (0.05 USP unit twice daily, i.p., 6 days) causes an increase in the weight of the thyroid but no increase in body weight in hereditary dwarf mice[9].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Homozygote snell-type dwarf mice[9]
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Dosage:0.05 USP unit
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Administration:Intraperitoneal injection (i.p.), 6 days, twice daily
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Result:Increased T4 plasma level by 185% over that of untreated dwarf mice.
Showed no change in the body weight.
caused an increase in the weight of the thyroid gland by approximately 80%.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 9002-71-5
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Appearance Solid
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Color White to off-white
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SMILES
[Thyrotropin]
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Synonyms
TSH; Pretiron
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Hormones (Athens)
2024 Dec;23(4):821-829. PMID: 38872063
Solvente y solubilidad
PBS : ≥ 1 mg/mL
* "≥" means soluble, but saturation unknown.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Wolf G. The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid. Nutr Rev. 2002 Nov;60(11):374-7. [Content Brief]
[2]. Vassart G, et al. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992 Aug;13(3):596-611. [Content Brief]
[3]. Kim SM, et al. Thyrotropin, Hyperthyroidism, and Bone Mass[J]. J Clin Endocrinol Metab. 2021 Nov 19;106(12):e4809-e4821. [Content Brief]
[4]. Chandrasekar A, et al. Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes[J]. Thyroid. 2024 Feb;34(2):261-273. [Content Brief]
[5]. Ono H, et al. Involvement of thyrotropin in photoperiodic signal transduction in mice. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18238-42. [Content Brief]
[6]. Marians RC, et al. Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15776-81. [Content Brief]
[7]. Colzani RM, et al. The effect of recombinant human thyrotropin (rhTSH) on thyroid function in mice and rats. Thyroid. 1998 Sep;8(9):797-801. [Content Brief]
[8]. van der Weerd K, van Hagen PM, Schrijver B, Heuvelmans SJ, Hofland LJ, Swagemakers SM, Bogers AJ, Dik WA, et al. Thyrotropin acts as a T-cell developmental factor in mice and humans. Thyroid. 2014 Jun;24(6):1051-61. [Content Brief]
[9]. Denef JF, et al. The influence of thyrotropin and growth hormone on the thyroid gland in the hereditary dwarf mouse: a morphometric study. Endocrinology. 1980 Oct;107(4):1249-57. [Content Brief]
[11]. Medina DL, et al. Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems. Eur J Endocrinol. 2000 Aug;143(2):161-78. [Content Brief]
[12]. Dumont JE, et al. Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol Rev. 1992 Jul;72(3):667-97. [Content Brief]
[13]. Li X, et al. Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells. Endocrinology. 1999 Dec;140(12):5962-70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thyrotropin Related Classifications
HY-107916 Related Classifications
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