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Comt - catechol-O-methyltransferase Gene

Also Known as Comt1; D16Wsu103e; D330014B15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12846

About Comt

Chromosome 16: 18,225,636-18,245,602 reverse strand.GRCm39:CM001009.3

This gene has 4 transcripts (splice variants), 276 orthologues, 2 paralogues and is associated with 57 phenotypes. Broad expression in liver adult (RPKM 254.4), subcutaneous fat pad adult (RPKM 175.4) and 25 other tissues.

Summary

Enables catechol O-methyltransferase activity. Acts upstream of or within cellular response to phosphate starvation and dopamine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study cognitive disorder and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ Cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Comt Products (3)

mRNA	Protein	Name
NM_001111062.1	NP_001104532.1	catechol O-methyltransferase
NM_001111063.1	NP_001104533.1	catechol O-methyltransferase
NM_007744.3	NP_031770.2	catechol O-methyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables catechol O-methyltransferase activity	IDA IDA: Inferred from direct assay	12188925	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within artery development	IMP IMP: Inferred from mutant phenotype	30237900	MGI
acts upstream of or within behavior	IMP IMP: Inferred from mutant phenotype	31164811	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	31164811	MGI
acts upstream of or within catecholamine metabolic process	IMP IMP: Inferred from mutant phenotype	11849292	MGI
acts upstream of or within cellular response to cocaine	IMP IMP: Inferred from mutant phenotype	17881525	MGI
acts upstream of or within cellular response to phosphate starvation	IDA IDA: Inferred from direct assay	23863468	MGI
acts upstream of or within cerebellar cortex morphogenesis	IMP IMP: Inferred from mutant phenotype	28556830	MGI
acts upstream of or within cholesterol efflux	IMP IMP: Inferred from mutant phenotype	30237900	MGI
acts upstream of or within cognition	IDA IDA: Inferred from direct assay	24509724	MGI
acts upstream of or within cognition	IMP IMP: Inferred from mutant phenotype	18674597	MGI
acts upstream of or within detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	20561508	MGI
acts upstream of or within dopamine catabolic process	IDA IDA: Inferred from direct assay	9520487	MGI
acts upstream of or within dopamine metabolic process	IDA IDA: Inferred from direct assay	23863468	MGI
acts upstream of or within dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	11849292	MGI
acts upstream of or within dopamine secretion	IDA IDA: Inferred from direct assay	24509724	MGI
acts upstream of or within dopamine secretion	IMP IMP: Inferred from mutant phenotype	12188925	MGI
acts upstream of or within exploration behavior	IMP IMP: Inferred from mutant phenotype	17707921	MGI
acts upstream of or within fear response	IMP IMP: Inferred from mutant phenotype	22192380	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	19139376	MGI
acts upstream of or within glomerulus development	IMP IMP: Inferred from mutant phenotype	22688335	MGI
acts upstream of or within glycogen metabolic process	IGI IGI: Inferred from genetic interaction	30179860	MGI
acts upstream of or within habituation	IMP IMP: Inferred from mutant phenotype	17707921	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	22169008	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	24639487	MGI
acts upstream of or within learning or memory	IDA IDA: Inferred from direct assay	24509724	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	18674597	MGI
acts upstream of or within mastication	IMP IMP: Inferred from mutant phenotype	17707921	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	31164811	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	30237900	MGI
acts upstream of or within multicellular organismal response to stress	IMP IMP: Inferred from mutant phenotype	31164811	MGI
acts upstream of or within norepinephrine metabolic process	IMP IMP: Inferred from mutant phenotype	11849292	MGI
acts upstream of or within norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	12188925	MGI
acts upstream of or within prostaglandin metabolic process	IMP IMP: Inferred from mutant phenotype	19770404	MGI
acts upstream of or within protein methylation	IMP IMP: Inferred from mutant phenotype	17724020	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	30238463	MGI
acts upstream of or within regulation of blood pressure	IGI IGI: Inferred from genetic interaction	30179860	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	19770404	MGI
acts upstream of or within renal albumin absorption	IMP IMP: Inferred from mutant phenotype	22169008	MGI
acts upstream of or within renal filtration	IMP IMP: Inferred from mutant phenotype	22688335	MGI
acts upstream of or within renal sodium excretion	IMP IMP: Inferred from mutant phenotype	12188925	MGI
acts upstream of or within renin secretion into blood stream	IMP IMP: Inferred from mutant phenotype	19139376	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	23169629	MGI
acts upstream of or within response to angiotensin	IMP IMP: Inferred from mutant phenotype	22169008	MGI
acts upstream of or within response to corticosterone	IMP IMP: Inferred from mutant phenotype	19770404	MGI
acts upstream of or within response to cytokine	IMP IMP: Inferred from mutant phenotype	22192380	MGI
acts upstream of or within response to dopamine	IMP IMP: Inferred from mutant phenotype	22169008	MGI
acts upstream of or within response to external stimulus	IMP IMP: Inferred from mutant phenotype	23169629	MGI
acts upstream of or within response to food	IMP IMP: Inferred from mutant phenotype	23169629	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	20075204	MGI
acts upstream of or within response to methylphenidate	IMP IMP: Inferred from mutant phenotype	31164811	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	19770404	MGI
acts upstream of or within response to salt	IMP IMP: Inferred from mutant phenotype	19139376	MGI
acts upstream of or within response to stress	IMP IMP: Inferred from mutant phenotype	22192380	MGI
acts upstream of or within response to temperature stimulus	IMP IMP: Inferred from mutant phenotype	24591155	MGI
acts upstream of or within response to toxic substance	IMP IMP: Inferred from mutant phenotype	24591155	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	22169008	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	11849292	MGI
acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	24509724	MGI
acts upstream of or within synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	17881525	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	24509724	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cytosol	IDA IDA: Inferred from direct assay	24591155	MGI
is active in cytosol	IMP IMP: Inferred from mutant phenotype	17724020	MGI
is active in vesicle	IDA IDA: Inferred from direct assay	24591155	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Comt Protein Structure

YrrM

0
100
200
265 a.a.

Protein Preferred Names	Protein Names
catechol O-methyltransferase	catechol-O-methyltransferase 1

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1473A	Serotonin	Inhibitor	99.86%	Unkown
HY-B1473	Serotonin hydrochloride	Inhibitor	99.97%	Unkown
HY-17406	Tolcapone	Inhibitor	99.86%	Yes
HY-14280	Entacapone	Inhibitor	99.97%	Yes
HY-14896	Opicapone	Inhibitor	98.81%	Yes
HY-100562	Flopropione	Inhibitor	99.97%	Unkown
HY-B1473R	Serotonin hydrochloride (Standard)	Inhibitor	99.28%	Unkown
HY-14280R	Entacapone (Standard)	Inhibitor	99.24%	Unkown
HY-17406R	Tolcapone (Standard)	Inhibitor	/	Unkown
HY-14280A	Entacapone sodium salt	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0529	Rosmarinic acid	Inhibitor	99.73%	Phase 3
HY-106405	Nebicapone	Inhibitor	99.89%	Phase 2
HY-106842	Nitecapone	Inhibitor	98.71%	Phase 2
HY-19061	CGP 28014	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1473AS	Serotonin-d4	Inhibitor	99.61%	Unkown
HY-N0522	(-)-Gallocatechin gallate	Inhibitor	99.97%	Unkown
HY-B1473S	Serotonin-d4 hydrochloride	Inhibitor	99.48%	Unkown
HY-133068	5-Hydroxyferulic acid		99.43%	Unkown
HY-125339	Ro 41-0960	Inhibitor	98.22%	Unkown
HY-100959	3,5-Dinitrocatechol	Inhibitor	99.72%	Unkown
HY-W012264	3-O-Methyldopa monohydrate		99.16%	Unkown
HY-151388	hMAO-B/MB-COMT-IN-1	Inhibitor	98.04%	Unkown
HY-157719	S-Adenosylhomocysteine sulfoxide	Inhibitor	≥95.0%	Unkown
HY-128410	4-Phenyl-7,8-dihydroxycoumarin	Inhibitor	99.35%	Unkown
HY-17406S1	Tolcapone-d4	Inhibitor	99.13%	Unkown
HY-121949	U-0521	Inhibitor	98.67%	Unkown
HY-14280S	Entacapone-d10	Inhibitor	98.6%	Unkown
HY-120325	DHMPA	Inhibitor	/	Unkown
HY-W704878	(Z)-Entacapone-d10-1		/	Unkown
HY-17406S	Tolcapone-d7	Inhibitor	/	Unkown
HY-139089	(Z)-Entacapone	Inhibitor	/	Unkown
HY-100642S1	3-O-Methyltolcapone-d4	Inhibitor	/	Unkown
HY-133068A	(E)-5-Hydroxyferulic acid		/	Unkown
HY-100642S	3-O-Methyltolcapone-d7	Inhibitor	99.0%	Unkown
HY-169611	Serotonin maleate	Inhibitor	/	Unkown
HY-B1473S2	Serotonin-13C,D4		/	Unkown
HY-109119	Neluxicapone	Inhibitor	/	Unkown
HY-162760	COMT-IN-1	Inhibitor	/	Unkown
HY-151390	hMAO-B/MB-COMT-IN-2	Inhibitor	/	Unkown
HY-168154	COMT-IN-2	Inhibitor	/	Unkown
HY-156069	Methylspinazarin	Inhibitor	/	Unkown
HY-100642	3-O-Methyltolcapone	Inhibitor	99.95%	Unkown
HY-119224	BIA 3-335	Inhibitor	/	Unkown
HY-126194	Tolcapone 3-β-D-glucuronide	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Comt	NCBI	NCBI:1312