Mif - macrophage migration inhibitory factor (glycosylation-inhibiting factor) Gene

Also Known as GIF; DER6; Glif

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17319

Summary

Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cell aging; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Apr 2022]

Mif Products (1)

mRNA Protein Name
NM_010798.3 NP_034928.1 macrophage migration inhibitory factor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
10364264 MGI
enables phenylpyruvate tautomerase activity IMP
IMP: Inferred from mutant phenotype
16285950 MGI
enables protease binding IPI
IPI: Inferred from physical interaction
21817065 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
12878730 MGI
acts upstream of or within cellular senescence IMP
IMP: Inferred from mutant phenotype
12878730 MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
IDA: Inferred from direct assay
17045821 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
17045821 MGI
involved in negative regulation of mature B cell apoptotic process IDA
IDA: Inferred from direct assay
18056708 MGI
involved in negative regulation of myeloid cell apoptotic process IMP
IMP: Inferred from mutant phenotype
11756671 MGI
involved in negative regulation of protein metabolic process IDA
IDA: Inferred from direct assay
11756671 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
10364264 MGI
involved in positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
10364264 MGI
involved in positive regulation of arachidonate secretion IDA
IDA: Inferred from direct assay
10364264 MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
IDA: Inferred from direct assay
18056708 MGI
involved in positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
10364264 MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
11756671 MGI
involved in positive regulation of myeloid leukocyte cytokine production involved in immune response IMP
IMP: Inferred from mutant phenotype
11756671 MGI
involved in positive regulation of prostaglandin secretion involved in immune response IMP
IMP: Inferred from mutant phenotype
11756671 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
10364264 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12878730 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11756671 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage migration inhibitory factor

  • L-dopachrome isomerase

  • L-dopachrome tautomerase

  • delayed early response protein 6

  • phenylpyruvate tautomerase

Recombinant Mif Proteins

Cat. No. Product Name Accession Purity
HY-P7388 MIF Protein, Mouse P34884 (M1-A115) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70341 MIF Protein, Mouse (His) P34884 (P2-A115) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70341AF Animal-Free MIF Protein, Mouse (His) P34884 (M1-A115) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700517 MIF Protein, Mouse (P. pastoris, His) P34884 (P2-A115) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17009 Iguratimod Inhibitor 98.49% Yes

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-121356 Carebastine 99.23% Phase 3
HY-105077A Nemifitide diTFA 98.24% Phase 2
HY-16692 ISO-1 Inhibitor 99.84% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99262 Imalumab Inhibitor 98.37% Phase 2

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110063 4-IPP Inhibitor 99.40% Unkown
HY-147390 MIF098 Inhibitor 99.99% Unkown
HY-110095 (±)-CPSI-1306 Antagonist 99.64% Unkown
HY-130332 Mitomycin A Inhibitor 98.3% Unkown
HY-W019710 (E,E)-RGFP966 Inhibitor 99.44% Unkown
HY-107663A MIF-1 TFA Modulator 99.34% Unkown
HY-148117 MD13 99.96% Unkown
HY-110084 BTZO-1 99.32% Unkown
HY-123814 4-CPPC Inhibitor 98.20% Unkown
HY-N10096 Epoxyazadiradione 99.24% Unkown
HY-W164560 RDR 03785 Inhibitor 97.05% Unkown
HY-149308 MKA031 Inhibitor 98.69% Unkown
HY-D0039 3-Cyanoumbelliferone ≥98.0% Unkown
HY-115887 R110 Inhibitor 99.90% Unkown
HY-RS08445 MIF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12386 S100A9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173624 TE-11 Inhibitor 99.68% Unkown
HY-107663 MIF-1 Modulator / Unkown
HY-115888 MIF2-IN-1 Inhibitor / Unkown
HY-123970 ISO-92 Inhibitor / Unkown
HY-144190 MIF-IN-1 Inhibitor / Unkown
HY-144196 MIF-IN-4 hydrochloride Inhibitor / Unkown
HY-146318 MIF-IN-5 Inhibitor / Unkown
HY-146319 MIF-IN-6 Inhibitor / Unkown
HY-181912 D-DT/MIF-1-IN-1 Inhibitor / Unkown
HY-182935 PAANIB-1 Inhibitor / Unkown
HY-P3087 Tyr-W-MIF-1 Modulator / Unkown
HY-RS00653 AMH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12385 S100A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W415753 Alaptide / Unkown
HY-155466 Boc-MIF-1-Am Activator / Unkown
HY-174842 HTS05585 Inhibitor / Unkown
HY-RS16522 Mif Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22953 Mif Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00271 Pareptide monohydrochloride / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mif NCBI NCBI:4282