Pde4d - phosphodiesterase 4D Gene

Also Known as DPDE3; PDE3/IVd

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24627

Summary

Enables beta-2 Adrenergic Receptor binding activity; cyclic-nucleotide phosphodiesterase activity; and enzyme binding activity. Involved in several processes, including positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; and regulation of signal transduction. Located in several cellular components, including Golgi apparatus; centrosome; and myofibril. Part of protein-containing complex. Used to study mental depression. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D). [provided by Alliance of Genome Resources, Apr 2022]

Pde4d Products (5)

mRNA Protein Name
NM_001113328.2 NP_001106799.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 1
NM_001113329.2 NP_001106800.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 2
NM_001113332.2 NP_001106803.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 3
NM_001113334.2 NP_001106805.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 4
NM_017032.2 NP_058728.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-2 adrenergic receptor binding IPI
IPI: Inferred from physical interaction
19801680 RGD
enables cyclic-nucleotide phosphodiesterase activity IDA
IDA: Inferred from direct assay
12834813 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
22975349 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11134006 RGD
enables signaling receptor regulator activity IMP
IMP: Inferred from mutant phenotype
19801680 RGD
Biological Process GO Annotation Evidence References Source
involved in adrenergic receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19801680 RGD
involved in establishment of endothelial barrier IDA
IDA: Inferred from direct assay
20139324 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
20652950 RGD
involved in memory IEP
IEP: Inferred from expression pattern
15302115 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
21649644 RGD
involved in positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
18073242 RGD
involved in positive regulation of heart rate IMP
IMP: Inferred from mutant phenotype
19801680 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
18073242 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
21776361 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
21776361 RGD
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
11134006 RGD
involved in regulation of cAMP/PKA signal transduction IMP
IMP: Inferred from mutant phenotype
18073242 RGD
involved in regulation of cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
19801680 RGD
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
11134006 RGD
located in myofibril IDA
IDA: Inferred from direct assay
11134006 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11296225 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

  • 3',5'-cyclic AMP phosphodiesterase

  • cAMP-specific phosphodiesterase PDE4D

  • phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-117571 Zatolmilast Inhibitor 99.50% Phase 3
HY-117960 Orismilast Inhibitor 99.88% Phase 2
HY-15178 Oglemilast Inhibitor 99.97% Phase 2
HY-155830 Morcamilast Inhibitor 98.92% Phase 2
HY-108047 MK-0873 Inhibitor 95.0% Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1
HY-131707 LEO 39652 Inhibitor 99.40% Phase 1
HY-201403 LY2775240 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122942 Moracin M 98.99% Unkown
HY-15444 D159687 Inhibitor 98.42% Unkown
HY-128358 MR-L2 Activator 98.63% Unkown
HY-115687 PDE4B-IN-2 Inhibitor 99.59% Unkown
HY-119190 PF-06445974 Inhibitor 98.59% Unkown
HY-16900A (R)-(-)-Rolipram Inhibitor 99.91% Unkown
HY-103050 ML-030 Inhibitor 99.28% Unkown
HY-139178 KVA-D-88 Inhibitor 99.81% Unkown
HY-100246 CI-1044 Inhibitor 98.02% Unkown
HY-169981 PDE4-IN-24 Inhibitor 99.44% Unkown
HY-117977 FCPR03 Inhibitor 99.82% Unkown
HY-121037 Eggmanone Inhibitor 95.31% Unkown
HY-161772 (S)-Gebr32a Inhibitor 98.97% Unkown
HY-RS10225 PDE4D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131340 LASSBio-1632 Inhibitor / Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-130262 PDE1-IN-3 Inhibitor / Unkown
HY-114052 NVP-ABE171 Inhibitor / Unkown
HY-115913 PDE4-IN-6 Inhibitor / Unkown
HY-120945 PDE10A-IN-1 Inhibitor / Unkown
HY-121041 GEBR-7b / Unkown
HY-147846 AChE/PDE4-IN-1 Inhibitor / Unkown
HY-14918 Catramilast Inhibitor / Unkown
HY-154957 mTOR inhibitor-11 Inhibitor / Unkown
HY-159654 PDE4-IN-19 Inhibitor / Unkown
HY-161936 Z21115 Inhibitor / Unkown
HY-162582 Z19153 Inhibitor / Unkown
HY-162583 PDE4-IN-17 Inhibitor / Unkown
HY-168558 PDE4B/D-IN-4 Inhibitor / Unkown
HY-170397 ADORA2A/PDE4D-IN-1 / Unkown
HY-172776 Phosphodiesterase-IN-3 Inhibitor / Unkown
HY-173290 PDE4D inhibitor 1 Inhibitor / Unkown
HY-176234 PDE4-IN-28 Inhibitor / Unkown
HY-176520 PDE4-IN-29 Inhibitor / Unkown
HY-179407 LT-104A Inhibitor / Unkown
HY-180803 LH17 Inhibitor / Unkown
HY-181549 PDE4-IN-32 Inhibitor / Unkown
HY-181646 PDE4-IN-34 Inhibitor / Unkown
HY-181774 PDE4/5-IN-1 Inhibitor / Unkown
HY-182060 PDE4B/D-IN-5 / Unkown
HY-119799 UK-500001 Inhibitor / Unkown
HY-RS17612 Pde4d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24072 Pde4d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde4d NCBI NCBI:5144