Myd88 - MYD88, innate immune signal transduction adaptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 301059

About Myd88

Primary_assembly 8: 119,074,437-119,079,415 reverse strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 200 orthologues and is associated with 61 phenotypes. Biased expression in Spleen (RPKM 125.3), Thymus (RPKM 16.6) and 9 other tissues.

Summary

Enables Toll binding activity and interleukin-1 receptor binding activity. Involved in JNK cascade; cell surface receptor signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in postsynaptic density. Part of protein-containing complex. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MyD88 (MyD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Myd88 Products (1)

mRNA Protein Name
NM_198130.2 NP_937763.2 myeloid differentiation primary response protein MyD88

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Toll binding IDA
IDA: Inferred from direct assay
14962484 RGD
enables interleukin-1 receptor binding IPI
IPI: Inferred from physical interaction
21314939 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19144836 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
14962484 RGD
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in Toll signaling pathway IDA
IDA: Inferred from direct assay
14962484 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
31068809 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
21276439 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
21276439 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
33575076 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
21314939 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Myd88 Protein Structure

Death_MyD88

Death_MyD88: cd08312 (28 - 105)

TIR

TIR: smart00255 (160 - 295)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

myeloid differentiation primary response protein MyD88

  • myeloid differentiation primary response 88

  • myeloid differentiation primary response gene 88

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-112137 Trehalose-6,6'-dibehenate 99.92% Phase 3
HY-135317 Emavusertib Inhibitor 99.97% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99555 Tomaralimab Inhibitor 99.42% Phase 2

Pre-clinical Phase

Bioactive Molecules (58)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139397 TJ-M2010-5 Inhibitor 99.94% Unkown
HY-50937 ST 2825 Inhibitor 99.92% Unkown
HY-110204 Heclin 98.00% Unkown
HY-N0703 Schaftoside Inhibitor 99.70% Unkown
HY-Y1881B Copper sulfate pentahydrate, for cell culture, 98% Inhibitor 99.99% Unkown
HY-160229 ssRNA40 sodium Activator 98.34% Unkown
HY-19744 T6167923 Inhibitor 99.70% Unkown
HY-Y1881A Copper sulfate pentahydrate, 99.9% Inhibitor 99.90% Unkown
HY-149992 MyD88-IN-1 Inhibitor 99.95% Unkown
HY-110195 Smurf1-IN-A01 99.81% Unkown
HY-N7088 Raffinose Inhibitor 98.0% Unkown
HY-Y0278 Chloranil Inducer 98% Unkown
HY-18976 UF010 99.83% Unkown
HY-N4093 Astringin Inhibitor 99.54% Unkown
HY-N0237 Atractyloside A Inhibitor 98.11% Unkown
HY-129440 N-(p-Coumaroyl) Serotonin Inhibitor 99.03% Unkown
HY-P10719 Pepinh-MYD Inhibitor 99.85% Unkown
HY-W014223 2,4′-Dihydroxybenzophenone Inhibitor 98.00% Unkown
HY-P10719A Pepinh-MYD TFA Inhibitor 98.98% Unkown
HY-W097625 6-Methoxyflavone Inhibitor 99.73% Unkown
HY-170446 MyD88-IN-2 Inhibitor 99.94% Unkown
HY-173063 TLR8 antagonist-1 Inhibitor 99.95% Unkown
HY-N0320 Salvianolic acid D Inhibitor 95.15% Unkown
HY-N7653 Azaleatin Inhibitor 98.86% Unkown
HY-N2896 Arjunolic acid Inhibitor 98.83% Unkown
HY-W011400 TLR1 99.43% Unkown
HY-178136 MyD88-IN-3 Inhibitor 99.33% Unkown
HY-164670 D228 Inhibitor 99.77% Unkown
HY-NP134 Flagellin from S. typhimurium Activator 95% Unkown
HY-RS08886 MYD88 Human Pre-designed siRNA Set A Inhibitor / Unkown
HY-179474 TSI-13-57 Inhibitor 98.73% Unkown
HY-N3979 Grossamide Inhibitor 98.0% Unkown
HY-135317B Emavusertib hydrochloride Inhibitor / Unkown
HY-180336 LM9 Inhibitor / Unkown
HY-184470 MyD88 degrader-1 Degrader / Unkown
HY-173309 P53/TLR2 modulator-1 Inducer / Unkown
HY-107272 Chuanbeinone Inhibitor / Unkown
HY-179047 SMU-L11-R Activator / Unkown
HY-N19847 LYRM03 Inhibitor / Unkown
HY-180580 SMU-C409 Activator / Unkown
HY-184654 MR-39 Inhibitor / Unkown
HY-P11913 Antimicrobial Peptide YD Inhibitor / Unkown
HY-163775 Anti-inflammatory agent 88 Agonist / Unkown
HY-178690 MyD88-IN-4 Inhibitor / Unkown
HY-RS08887 Myd88 Mouse Pre-designed siRNA Set A Inhibitor / Unkown
HY-P10178 Myristoylated ARF6 (2-13) Inhibitor / Unkown
HY-155801 CRX 527 Activator / Unkown
HY-125447 Artemisinin B Inhibitor / Unkown
HY-RS08888 Myd88 Rat Pre-designed siRNA Set A Inhibitor / Unkown
HY-P5762A Phoenixin-14 TFA Inhibitor / Unkown
HY-183400 BIM-46174 Inhibitor / Unkown
HY-N9164 Hecubine Inhibitor / Unkown
HY-135317F Emavusertib phosphate Inhibitor / Unkown
HY-135317C Emavusertib tosylate Inhibitor / Unkown
HY-135317E Emavusertib maleate Inhibitor / Unkown
HY-175637 COX-2-IN-57 Inhibitor / Unkown
HY-135317D Emavusertib mesylate Inhibitor / Unkown
HY-Y0278R Chloranil (Standard) Inducer / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myd88 NCBI NCBI:4615