Dhps - deoxyhypusine synthase Gene

Also Known as Dhs

Species: Mus musculus

Gene Type: protein coding
Gene ID: 330817

Summary

Predicted to enable deoxyhypusine synthase activity and identical protein binding activity. Acts upstream of or within glucose homeostasis; peptidyl-lysine modification to peptidyl-hypusine; and positive regulation of T cell proliferation. Predicted to be active in cytoplasm. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Apr 2022]

Dhps Products (1)

mRNA Protein Name
NM_001039514.1 NP_001034603.1 deoxyhypusine synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables deoxyhypusine synthase activity IMP
IMP: Inferred from mutant phenotype
8697449 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
24196968 MGI
acts upstream of or within peptidyl-lysine modification to peptidyl-hypusine IMP
IMP: Inferred from mutant phenotype
24196968 MGI
involved in peptidyl-lysine modification to peptidyl-hypusine IMP
IMP: Inferred from mutant phenotype
24196968 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
24196968 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
3126083 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

deoxyhypusine synthase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0273 Sulfadiazine Inhibitor 99.89% Yes
HY-B0212 Sulfapyridine Inhibitor 99.85% Yes
HY-B0273A Sulfadiazine sodium Inhibitor 98.0% Yes
HY-B0212R Sulfapyridine (Standard) Inhibitor 99.86% Unkown
HY-B0273R Sulfadiazine (Standard) Inhibitor 99.84% Unkown
HY-B0273AR Sulfadiazine sodium (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106927 Bay Y5959 Agonist / Phase 2
HY-106808 Cerebrocrast Inhibitor 99.51% Phase 1

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108314A GC7 Sulfate Inhibitor 98.0% Unkown
HY-115712 DHPS-IN-1 Inhibitor 99.78% Unkown
HY-135218A AV-153 free base Activator 99.59% Unkown
HY-W761300 1-(4-Pip-Ph)-DHP-dione 99.04% Unkown
HY-B0273S Sulfadiazine-d4 Inhibitor 99.31% Unkown
HY-101390 (+)-Niguldipine hydrochloride Ligand 98.06% Unkown
HY-108314 GC-7 Inhibitor / Unkown
HY-161027 2,6-Didehydropeperomin B / Unkown
HY-RS03737 DHPS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011231 DHP-050 98.58% Unkown
HY-B0612DS1 Lercanidipine-d3 hydrochloride Inhibitor 98.26% Unkown
HY-106832 Vatanidipine Antagonist / Unkown
HY-106832A Vatanidipine hydrochloride Antagonist / Unkown
HY-117090 (rac)-AL-37350A Agonist / Unkown
HY-135218 AV-153 Activator / Unkown
HY-147721 Dihydropteroate synthase-IN-1 Inhibitor / Unkown
HY-155804 RIP1 kinase inhibitor 8 Inhibitor / Unkown
HY-175828 DHPS-IN-2 Inhibitor / Unkown
HY-182529 DHPS-IN-3 / Unkown
HY-184113 Dihydropelitinib / Unkown
HY-B0273S1 Sulfadiazine-13C6 Inhibitor 99.18% Unkown
HY-B0612AS Lercanidipine-13C,d3 hydrochloride / Unkown
HY-B0612AS1 Lercanidipine-13C,d3-1 hydrochloride Inhibitor / Unkown
HY-N18471 5,7-Dihydroxytryptamine Ligand / Unkown
HY-106766 DHP-218 Antagonist / Unkown
HY-111282 MK-789 Antagonist / Unkown
HY-120411 Sadopine Modulator / Unkown
HY-126171 Hypusine / Unkown
HY-135062 9-Methylguanine Inhibitor / Unkown
HY-172109 DNA Gyrase-IN-15 Inhibitor / Unkown
HY-B0273B Sulfadiazine 100 µg/mL in methanol Inhibitor 99.68% Unkown
HY-RS18754 Dhps Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25241 Dhps Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhps NCBI NCBI:1725