DHFR - dihydrofolate reductase Gene
Species: Canis lupus familiaris (sub-species: familiaris)
Gene Type: protein coding
Gene ID: 479165
About DHFR
Primary_assembly 3: 26,441,755-26,468,894 forward strand.ROS_Cfam_1.0:CM025102.1
This gene has 2 transcripts (splice variants), 346 orthologues and 4 paralogues.
DHFR Products (5)
| mRNA | Protein | Name |
|---|---|---|
| XM_038660943.1 | XP_038516871.1 | dihydrofolate reductase isoform X5 |
| XM_038660939.1 | XP_038516867.1 | dihydrofolate reductase isoform X1 |
| XM_038660941.1 | XP_038516869.1 | dihydrofolate reductase isoform X3 |
| XM_038660942.1 | XP_038516870.1 | dihydrofolate reductase isoform X4 |
| XM_038660940.1 | XP_038516868.1 | dihydrofolate reductase isoform X2 |
DHFR Protein Structure
DHFR
DHFR: cd00209 (4 - 161)
- 0
- 100
- 189 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
dihydrofolate reductase |
|
Related Agents
- Approval
- Clinical Phase
- Pre-clinical Phase
Approval
Bioactive Molecules
(13)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-10820 | Pemetrexed | Inducer | 99.97% | Unkown |
| HY-10446 | Pralatrexate | Inducer | 99.23% | Yes |
| HY-10820A | Pemetrexed disodium | Inducer | 99.79% | Unkown |
| HY-18062 | Pyrimethamine | 99.99% | Yes | |
| HY-10373 | Trimetrexate | Inhibitor | 99.60% | Unkown |
| HY-B0806 | Proguanil | Inhibitor | 99.84% | Unkown |
| HY-13781 | Pemetrexed disodium hemipenta hydrate | Inducer | 99.78% | Unkown |
| HY-10820B | Pemetrexed disodium heptahydrate | 99.97% | Unkown | |
| HY-I0447 | 4-Aminosalicylic acid | Inhibitor | 99.82% | Yes |
| HY-I0447A | Sodium 4-aminosalicylate dihydrate | Inhibitor | 99.95% | Yes |
| HY-B0806A | Proguanil hydrochloride | Inhibitor | 99.21% | Unkown |
| HY-10373A | Trimetrexate trihydrochloride | Inhibitor | / | Unkown |
| HY-10373B | Trimetrexate isethionate | Inhibitor | / | Unkown |
Clinical Phase
Bioactive Molecules
(5)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-14518 | Aminopterin | Antagonist | 99.33% | Phase 2 |
| HY-10824 | Talotrexin | 99.27% | Phase 2 | |
| HY-106434 | Piritrexim | Inhibitor | 99.07% | Phase 2 |
| HY-10824A | Talotrexin monoammonium | Inhibitor | / | Phase 2 |
| HY-10824B | Talotrexin ammonium | Inhibitor | / | Phase 2 |
Pre-clinical Phase
Bioactive Molecules
(106)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-116387 | WR99210 | Inhibitor | 99.10% | Unkown |
| HY-12784A | Cycloguanil hydrochloride | Inhibitor | 99.93% | Unkown |
| HY-N0913 | Manninotriose | Modulator | 99.97% | Unkown |
| HY-W587663 | 4′-DTMP | Inhibitor | 97.33% | Unkown |
| HY-116387A | WR99210 hydrochloride | Inhibitor | 98.34% | Unkown |
| HY-107033 | Tetroxoprim | Inhibitor | 98.97% | Unkown |
| HY-162475 | Fluorofolin | Inhibitor | 99.85% | Unkown |
| HY-W003561 | DHFR-IN-3 | Inhibitor | 99.48% | Unkown |
| HY-126316 | Zapalog | Modulator | 99.62% | Unkown |
| HY-RS03730 | DHFR Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-18062S | Pyrimethamine-d3 | 99.90% | Unkown | |
| HY-139743 | Aditoprime | Inhibitor | 99.68% | Unkown |
| HY-151159 | DHFR-IN-4 | Inhibitor | 99.19% | Unkown |
| HY-B1902 | Diaveridine | 99.79% | Unkown | |
| HY-137129 | 10-Formyl-7,8-dihydrofolic acid | Substrate | 97.70% | Unkown |
| HY-153007 | DHFR-IN-5 | Inhibitor | 99.27% | Unkown |
| HY-169790 | Phomarin | Inhibitor | 98.53% | Unkown |
| HY-137439 | Fanotaprim | 98.89% | Unkown | |
| HY-12784 | Cycloguanil | Inhibitor | / | Unkown |
| HY-12784S | Cycloguanil-d6 | Inhibitor | 98.0% | Unkown |
| HY-176557 | NCI677397 | / | Unkown | |
| HY-B0806AS1 | Proguanil-d6 hydrochloride | Inhibitor | 98.73% | Unkown |
| HY-22252 | 4-Aminosalicylic acid hemicalcium | Inhibitor | / | Unkown |
| HY-12784AS | Cycloguanil-d4 hydrochloride | Inhibitor | / | Unkown |
| HY-10446S1 | Pralatrexate-13C5,15N | Inducer | / | Unkown |
| HY-10820AS | Pemetrexed-d5 disodium | Inducer | / | Unkown |
| HY-10820S | Pemetrexed-d5 | / | Unkown | |
| HY-116039 | Epiroprim | Inhibitor | / | Unkown |
| HY-117000 | D156844 | Agonist | / | Unkown |
| HY-117000A | D156844 hydrochloride | Agonist | / | Unkown |
| HY-117791 | (R)-Pralatrexate | Control | / | Unkown |
| HY-121207 | Denopterin | Inhibitor | / | Unkown |
| HY-122045 | CB 3705 | Inhibitor | / | Unkown |
| HY-122289 | Metioprim | Inhibitor | / | Unkown |
| HY-12784AR | Cycloguanil hydrochloride (Standard) | Inhibitor | / | Unkown |
| HY-12784AS1 | Cycloguanil-d6 hydrochloride | Inhibitor | / | Unkown |
| HY-12784S1 | Cycloguanil-d6 nitrate | Inhibitor | / | Unkown |
| HY-137357 | 5-Monobutyl methotrexate | Inhibitor | / | Unkown |
| HY-143236 | DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-147661 | DHFR-IN-2 | Inhibitor | / | Unkown |
| HY-149200 | Lysine-methotrexate | / | Unkown | |
| HY-149632 | EGFR/HER2/DHFR-IN-2 | Inhibitor | / | Unkown |
| HY-149633 | EGFR/HER2/DHFR-IN-3 | / | Unkown | |
| HY-149958 | Antileishmanial agent-17 | Inhibitor | / | Unkown |
| HY-151154 | EGFR/HER2/DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-151156 | EGFR/HER2-IN-6 | / | Unkown | |
| HY-151158 | EGFR/HER2-IN-7 | Inhibitor | / | Unkown |
| HY-151161 | EGFR/HER2-IN-8 | Inhibitor | / | Unkown |
| HY-151458 | VEGFR-2/DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-151459 | VEGFR-2/DHFR-IN-2 | Inhibitor | / | Unkown |
| HY-154807 | DQn-1 | Inhibitor | / | Unkown |
| HY-156122 | DHFR-IN-8 | Inhibitor | / | Unkown |
| HY-156123 | DHFR-IN-9 | Inhibitor | / | Unkown |
| HY-156859 | NSC309401 dihydrochloride | Inhibitor | / | Unkown |
| HY-160254 | 1954U89 | Inhibitor | / | Unkown |
| HY-162358 | DHFR-IN-17 | Inhibitor | / | Unkown |
| HY-163722 | EGFR/DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-168648 | DNA Gyrase/DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-168918 | Insecticidal agent 19 | Inhibitor | / | Unkown |
| HY-172897 | EGFR/DHFR-IN-2 | / | Unkown | |
| HY-173220 | DHFR-IN-23 | / | Unkown | |
| HY-178728 | BION106 | / | Unkown | |
| HY-178759 | DHFR-IN-5-amino-PEG3-C2-azido | / | Unkown | |
| HY-183053 | UCP1173 | Inhibitor | / | Unkown |
| HY-183286 | DHFR-IN-27 | Inhibitor | / | Unkown |
| HY-185443 | UCP1172 | Inhibitor | / | Unkown |
| HY-19095 | TNP-351 | / | Unkown | |
| HY-19885 | AR-102 | Inhibitor | / | Unkown |
| HY-B0806S1 | Proguanil-d4 | / | Unkown | |
| HY-B1902S | Diaveridine-d6 | / | Unkown | |
| HY-E70522 | Dihydrofolate reductase | / | Unkown | |
| HY-I0447S | 4-Aminosalicylic acid-d6 | / | Unkown | |
| HY-N10791 | Neobritannilactone B | / | Unkown | |
| HY-RS03731 | Dhfr Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS03732 | Dhfr Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-W769288 | Pemetrexed disodium-13C5 | / | Unkown | |
| HY-Z15986 | Methotrexate diethyl ester | Inhibitor | / | Unkown |
| HY-105714 | Etoprine | Inhibitor | / | Unkown |
| HY-115836 | DDPO | Inhibitor | / | Unkown |
| HY-118251 | PD130883 | Inhibitor | / | Unkown |
| HY-119613 | Clociguanil | Inhibitor | / | Unkown |
| HY-143408 | OYYF-175 | Inhibitor | / | Unkown |
| HY-149699 | DHFR-IN-12 | Inhibitor | / | Unkown |
| HY-153007A | DHFR-IN-5 hydrochloride | Inhibitor | / | Unkown |
| HY-156412 | DHFR-IN-10 | Inhibitor | / | Unkown |
| HY-156414 | DHFR-IN-11 | Inhibitor | / | Unkown |
| HY-156859A | NSC309401 | Inhibitor | / | Unkown |
| HY-159899 | DHFR-IN-22 | Inhibitor | / | Unkown |
| HY-161010 | DHFR-IN-13 | Inhibitor | / | Unkown |
| HY-161063 | DHFR-IN-14 | Inhibitor | / | Unkown |
| HY-161064 | DHFR-IN-15 | Inhibitor | / | Unkown |
| HY-161292 | DHFR-IN-16 | Inhibitor | / | Unkown |
| HY-162656 | DHFR-IN-19 | Inhibitor | / | Unkown |
| HY-163725 | DHFR-IN-18 | Inhibitor | / | Unkown |
| HY-168069 | DHFR-IN-20 | Inhibitor | / | Unkown |
| HY-169211 | DHFR-IN-21 | / | Unkown | |
| HY-177337 | N-Didesmethyladitoprim | Inhibitor | / | Unkown |
| HY-179415 | DHFR-IN-24 | Inhibitor | / | Unkown |
| HY-179493 | DHFR-IN-25 | Inhibitor | / | Unkown |
| HY-181100 | DHFR-IN-26 | Inhibitor | / | Unkown |
| HY-181813 | PROTAC DHFR Degrader-1 | / | Unkown | |
| HY-181814 | DHFR ligand-Linker Conjugate 1 | / | Unkown | |
| HY-182684 | MMV675968 | Inhibitor | / | Unkown |
| HY-B0806AS | Proguanil-d4 hydrochloride | Inhibitor | / | Unkown |
| HY-N3764 | Diosbulbin C | Activator | / | Unkown |
| HY-W167448 | DHFR-IN-28 | Inhibitor | / | Unkown |
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