2. Gene
  3. DHFR - dihydrofolate reductase Gene

DHFR - dihydrofolate reductase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 479165 | Gene type: protein coding

About DHFR

Primary_assembly 3: 26,441,755-26,468,894 forward strand.ROS_Cfam_1.0:CM025102.1

This gene has 2 transcripts (splice variants), 346 orthologues and 4 paralogues.

DHFR Products(5)

mRNA Protein Name
XM_038660943.1 XP_038516871.1 dihydrofolate reductase isoform X5
XM_038660939.1 XP_038516867.1 dihydrofolate reductase isoform X1
XM_038660941.1 XP_038516869.1 dihydrofolate reductase isoform X3
XM_038660942.1 XP_038516870.1 dihydrofolate reductase isoform X4
XM_038660940.1 XP_038516868.1 dihydrofolate reductase isoform X2

DHFR Protein Structure

DHFR

DHFR: cd00209 (4 - 161)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

dihydrofolate reductase

Related Agents

Approval
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10820 Pemetrexed Inducer 99.97% Unkown
HY-10446 Pralatrexate Inducer 99.23% Yes
HY-10820A Pemetrexed disodium Inducer 99.79% Unkown
HY-18062 Pyrimethamine 99.99% Yes
HY-10373 Trimetrexate Inhibitor 99.60% Unkown
HY-B0806 Proguanil Inhibitor 99.84% Unkown
HY-13781 Pemetrexed disodium hemipenta hydrate Inducer 99.78% Unkown
HY-10820B Pemetrexed disodium heptahydrate 99.97% Unkown
HY-I0447 4-Aminosalicylic acid Inhibitor 99.82% Yes
HY-I0447A Sodium 4-aminosalicylate dihydrate Inhibitor 99.95% Yes
HY-B0806A Proguanil hydrochloride Inhibitor 99.21% Unkown
HY-10373A Trimetrexate trihydrochloride Inhibitor / Unkown
HY-10373B Trimetrexate isethionate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-14518 Aminopterin Antagonist 99.33% Phase 2
HY-10824 Talotrexin 99.27% Phase 2
HY-106434 Piritrexim Inhibitor 99.07% Phase 2
HY-10824A Talotrexin monoammonium Inhibitor / Phase 2
HY-10824B Talotrexin ammonium Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (103)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-116387 WR99210 Inhibitor 99.10% Unkown
HY-12784A Cycloguanil hydrochloride Inhibitor 99.93% Unkown
HY-N0913 Manninotriose 99.97% Unkown
HY-W587663 4′-DTMP Inhibitor 97.33% Unkown
HY-107033 Tetroxoprim Inhibitor 99.32% Unkown
HY-116387A WR99210 hydrochloride Inhibitor 98.34% Unkown
HY-W003561 DHFR-IN-3 Inhibitor 99.48% Unkown
HY-126316 Zapalog Modulator 99.62% Unkown
HY-162475 Fluorofolin Inhibitor 99.85% Unkown
HY-RS03730 DHFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-139743 Aditoprime Inhibitor 99.68% Unkown
HY-151159 DHFR-IN-4 Inhibitor 99.19% Unkown
HY-B1902 Diaveridine 99.79% Unkown
HY-153007 DHFR-IN-5 Inhibitor 99.27% Unkown
HY-169790 Phomarin Inhibitor 98.53% Unkown
HY-18062S Pyrimethamine-d3 99.90% Unkown
HY-137439 Fanotaprim 98.89% Unkown
HY-12784 Cycloguanil Inhibitor / Unkown
HY-12784S Cycloguanil-d6 Inhibitor 98.0% Unkown
HY-176557 NCI677397 / Unkown
HY-B0806AS1 Proguanil-d6 hydrochloride Inhibitor 98.73% Unkown
HY-137129 10-Formyl-7,8-dihydrofolic acid Substrate 97.70% Unkown
HY-22252 4-Aminosalicylic acid hemicalcium Inhibitor / Unkown
HY-12784AS Cycloguanil-d4 hydrochloride Inhibitor / Unkown
HY-10820AS Pemetrexed-d5 disodium Inducer / Unkown
HY-10820S Pemetrexed-d5 / Unkown
HY-116039 Epiroprim Inhibitor / Unkown
HY-117000 D156844 Agonist / Unkown
HY-117000A D156844 hydrochloride Agonist / Unkown
HY-117791 (R)-Pralatrexate Control / Unkown
HY-121207 Denopterin Inhibitor / Unkown
HY-122045 CB 3705 Inhibitor / Unkown
HY-122289 Metioprim Inhibitor / Unkown
HY-12784AR Cycloguanil hydrochloride (Standard) Inhibitor / Unkown
HY-12784AS1 Cycloguanil-d6 hydrochloride Inhibitor / Unkown
HY-12784S1 Cycloguanil-d6nitrate Inhibitor / Unkown
HY-137357 5-Monobutyl methotrexate Inhibitor / Unkown
HY-143236 DHFR-IN-1 Inhibitor / Unkown
HY-147661 DHFR-IN-2 Inhibitor / Unkown
HY-149200 Lysine-methotrexate / Unkown
HY-149632 EGFR/HER2/DHFR-IN-2 Inhibitor / Unkown
HY-149633 EGFR/HER2/DHFR-IN-3 / Unkown
HY-149958 Antileishmanial agent-17 Inhibitor / Unkown
HY-151154 EGFR/HER2/DHFR-IN-1 Inhibitor / Unkown
HY-151156 EGFR/HER2-IN-6 / Unkown
HY-151158 EGFR/HER2-IN-7 Inhibitor / Unkown
HY-151161 EGFR/HER2-IN-8 Inhibitor / Unkown
HY-151458 VEGFR-2/DHFR-IN-1 Inhibitor / Unkown
HY-151459 VEGFR-2/DHFR-IN-2 Inhibitor / Unkown
HY-154807 DQn-1 Inhibitor / Unkown
HY-156122 DHFR-IN-8 Inhibitor / Unkown
HY-156123 DHFR-IN-9 Inhibitor / Unkown
HY-156859 NSC309401 dihydrochloride Inhibitor / Unkown
HY-160254 1954U89 Inhibitor / Unkown
HY-162358 DHFR-IN-17 Inhibitor / Unkown
HY-163722 EGFR/DHFR-IN-1 Inhibitor / Unkown
HY-168648 DNA Gyrase/DHFR-IN-1 Inhibitor / Unkown
HY-168918 Insecticidal agent 19 Inhibitor / Unkown
HY-172897 EGFR/DHFR-IN-2 / Unkown
HY-173220 DHFR-IN-23 / Unkown
HY-178728 BION106 / Unkown
HY-178759 DHFR-IN-5-amino-PEG3-C2-azido / Unkown
HY-183053 UCP1173 Inhibitor / Unkown
HY-183286 DHFR-IN-27 Inhibitor / Unkown
HY-185443 UCP1172 Inhibitor / Unkown
HY-19095 TNP-351 / Unkown
HY-19885 AR-102 Inhibitor / Unkown
HY-B0806S1 Proguanil-d4 / Unkown
HY-B1902S Diaveridine-d6 / Unkown
HY-E70522 Dihydrofolate reductase / Unkown
HY-I0447S 4-Aminosalicylic acid-d6 / Unkown
HY-N10791 Neobritannilactone B / Unkown
HY-RS03731 Dhfr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03732 Dhfr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W769288 Pemetrexed disodium-13C5 / Unkown
HY-Z15986 Methotrexate diethyl ester Inhibitor / Unkown
HY-115836 DDPO Inhibitor / Unkown
HY-118251 PD130883 Inhibitor / Unkown
HY-119613 Clociguanil Inhibitor / Unkown
HY-143408 OYYF-175 Inhibitor / Unkown
HY-149699 DHFR-IN-12 Inhibitor / Unkown
HY-153007A DHFR-IN-5 hydrochloride Inhibitor / Unkown
HY-156412 DHFR-IN-10 Inhibitor / Unkown
HY-156414 DHFR-IN-11 Inhibitor / Unkown
HY-156859A NSC309401 Inhibitor / Unkown
HY-159899 DHFR-IN-22 Inhibitor / Unkown
HY-161010 DHFR-IN-13 Inhibitor / Unkown
HY-161063 DHFR-IN-14 Inhibitor / Unkown
HY-161064 DHFR-IN-15 Inhibitor / Unkown
HY-161292 DHFR-IN-16 Inhibitor / Unkown
HY-162656 DHFR-IN-19 Inhibitor / Unkown
HY-163725 DHFR-IN-18 Inhibitor / Unkown
HY-168069 DHFR-IN-20 Inhibitor / Unkown
HY-169211 DHFR-IN-21 / Unkown
HY-177337 N-Didesmethyladitoprim Inhibitor / Unkown
HY-179415 DHFR-IN-24 Inhibitor / Unkown
HY-179493 DHFR-IN-25 Inhibitor / Unkown
HY-181100 DHFR-IN-26 Inhibitor / Unkown
HY-181813 PROTAC DHFR Degrader-1 / Unkown
HY-181814 DHFR ligand-Linker Conjugate 1 / Unkown
HY-182684 MMV675968 Inhibitor / Unkown
HY-B0806AS Proguanil-d4 hydrochloride Inhibitor / Unkown
HY-N3764 Diosbulbin C Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens DHFR NCBI NCBI:1719