HDAC9 - histone deacetylase 9 Gene

Also Known as MITR; RGD1310748; RGD1563092

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 687001

About HDAC9

Primary_assembly 6: 50,763,590-51,625,333 reverse strand.mRatBN7.2:CM026979.1

This gene has 4 transcripts (splice variants), 235 orthologues, 12 paralogues and is associated with 4 phenotypes. Biased expression in Spleen (RPKM 53.7), Heart (RPKM 45.8) and 9 other tissues.

Summary

Predicted to enable several functions, including enzyme binding activity; histone deacetylase activity (H4-K16 specific); and transcription corepressor activity. Involved in neuron differentiation and response to amphetamine. Located in nucleus. Biomarker of middle cerebral artery infarction. Orthologous to human HDAC9 (histone deacetylase 9). [provided by Alliance of Genome Resources, Apr 2022]

HDAC9 Products (1)

mRNA Protein Name
NM_001200045.1 NP_001186974.1 histone deacetylase 9

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
12850547 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
25452209 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC9 Protein Structure

ClassIIa_HDAC9_Gln-rich-N

ClassIIa_HDAC9_Gln-rich-N: cd10163 (58 - 147)

HDAC_classIIa

HDAC_classIIa: cd11681 (658 - 1035)

  • 0
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  • 1000
  • 1094 a.a.
Protein Preferred Names Protein Names

histone deacetylase 9

  • MEF2-interacting transcriptional repressor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-150109 Purinostat mesylate Inhibitor 99.45% Phase 3
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-16012A Domatinostat Inhibitor 99.34% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-112719 BRD 4354 Inhibitor 98.10% Unkown
HY-169259 HDAC9-IN-1 Inhibitor 95.13% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-112719B BRD 4354 ditrifluoroacetate Inhibitor 98.06% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens HDAC9 NCBI NCBI:9734