Rest - RE1-silencing transcription factor Gene

Also Known as Nrsf

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83618

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cellular biosynthetic process; negative regulation of dense core granule biogenesis; and response to ischemia. Located in chromatin and nucleus. Part of transcription repressor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Rest Products (1)

mRNA Protein Name
NM_031788.2 NP_113976.2 RE1-silencing transcription factor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9454838 RGD
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19342457 RGD
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17130167 RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17130167 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21284946 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
10491605 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10490617 RGD
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
22371606 RGD
involved in modification of synaptic structure IMP
IMP: Inferred from mutant phenotype
22960932 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17130167 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11516394 RGD
involved in negative regulation of aldosterone biosynthetic process IMP
IMP: Inferred from mutant phenotype
19342457 RGD
involved in negative regulation of calcium ion-dependent exocytosis IMP
IMP: Inferred from mutant phenotype
21536750 RGD
involved in negative regulation of cortisol biosynthetic process IMP
IMP: Inferred from mutant phenotype
19342457 RGD
involved in negative regulation of dense core granule biogenesis IMP
IMP: Inferred from mutant phenotype
21536750 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25108103 RGD
involved in negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
12657670 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22960932 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
24841827 RGD
involved in positive regulation of programmed cell death IMP
IMP: Inferred from mutant phenotype
12657670 RGD
involved in response to ischemia IDA
IDA: Inferred from direct assay
22371606 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
12657670 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
11516394 RGD
located in nucleus IDA
IDA: Inferred from direct assay
7697725 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
10491605 RGD
part of transcription repressor complex IDA
IDA: Inferred from direct assay
17130167 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RE1-silencing transcription factor

  • neural-restrictive silencer factor

  • zinc finger transcription factor REST protein

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0069 Fludarabine 99.73% Yes
HY-A0083 Methacholine chloride Agonist ≥98.0% Yes
HY-70057 Safinamide Inhibitor 99.86% Yes
HY-17001 Flupirtine Maleate 99.97% Yes
HY-17001A Flupirtine 99.98% Yes
HY-70057A Safinamide mesylate Inhibitor 99.07% Yes
HY-B1194 Tetramisole hydrochloride 99.04% Unkown
HY-B0516 Articaine hydrochloride Inhibitor 99.38% Unkown
HY-A0083B Methacholine bromide Agonist / Unkown
HY-B0516A Articaine Inhibitor / Unkown
HY-B0516R Articaine hydrochloride (Standard) Inhibitor / Unkown
HY-B1194A Tetramisole / Unkown
HY-17001R Flupirtine Maleate (Standard) / Unkown
HY-B0069R Fludarabine (Standard) / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W709349 Flupirtine hydrochloride / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99344 Bamlanivimab Inhibitor 99.97% Phase 4

Pre-clinical Phase

Bioactive Molecules (54)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12680 PRN694 Inhibitor ≥99.0% Unkown
HY-136833 X5050 Inhibitor 98.05% Unkown
HY-120657 9-PAHSA 99.88% Unkown
HY-136460 Calcium ionophore I 99.6% Unkown
HY-W012282 3′-Deoxyuridine 98.0% Unkown
HY-W013712 GI-530159 Activator 99.45% Unkown
HY-Y0531 1-Adamantanol 99.64% Unkown
HY-W040240 L-(-)-Sorbose 97.0% Unkown
HY-149483 CVN417 Antagonist 99.93% Unkown
HY-N0046 Notoginsenoside Fe Inhibitor 99.99% Unkown
HY-RS11853 REST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113603 Tildacerfont Inhibitor 98.60% Unkown
HY-103178 MRE3008F20 Antagonist 99.70% Unkown
HY-106667 DL 071IT Inhibitor 98.81% Unkown
HY-142682 SCP1-IN-1 Inhibitor 98.42% Unkown
HY-142683 SCP1-IN-2 Inhibitor 98.77% Unkown
HY-116790B (±)-Penbutolol Antagonist 98.07% Unkown
HY-70057S1 Safinamide-d4-1 Inhibitor 98.90% Unkown
HY-P10817 Corza6 Inhibitor 97.63% Unkown
HY-P10817A Corza6 TFA Inhibitor 95.53% Unkown
HY-121628 Flusulfamide Inhibitor / Unkown
HY-152901 Chol-N3 / Unkown
HY-N10631 Paucimannose / Unkown
HY-W770410 9-PAHSA-13C4 99.9% Unkown
HY-144026S 9-PAHSA-d9 / Unkown
HY-103298 MNI-caged kainate / Unkown
HY-106718 Barucainide Inhibitor / Unkown
HY-110230 Flupirtine-d4 hydrochloride 99.87% Unkown
HY-125452 DiSBAC10 / Unkown
HY-137618B Rp-dGTPαS / Unkown
HY-159986 X-17 Inhibitor / Unkown
HY-161272 Nav1.8-IN-6 Inhibitor / Unkown
HY-162478 GR-28 / Unkown
HY-181874 E0714 Activator / Unkown
HY-183709 Nav1.8-IN-24 Inhibitor / Unkown
HY-184086 Cyclazosin / Unkown
HY-185207 CQ80 Inducer / Unkown
HY-A0083C Methacholine iodide Agonist / Unkown
HY-E71264 β-Acetylglucosaminidase 18A, Bacteroides thetaiotaomicron / Unkown
HY-P11705 PUMA2A / Unkown
HY-P11870 PADI4_7 Ligand / Unkown
HY-P5152 Scorpion toxin Tf2 Activator / Unkown
HY-W328882 3-(2-Aminopropyl)phenol / Unkown
HY-W709349S Flupirtine-d6 hydrochloride Activator / Unkown
HY-120657S 9-PAHSA-d4 / Unkown
HY-120657S1 9-PAHSA-d31 99.00% Unkown
HY-174754 Human CCL28 mRNA / Unkown
HY-174758 Human CCL24 mRNA / Unkown
HY-174759 Human CCL23 mRNA / Unkown
HY-174760 Human CCL22 mRNA / Unkown
HY-70057S4 Safinamide-d5 Inhibitor / Unkown
HY-D2482 Asante potassium green-1 AM / Unkown
HY-RS17141 Rest Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23588 Rest Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991479 Amtabafusp alfa 99% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rest NCBI NCBI:5978