CREB3L1 - cAMP responsive element binding protein 3 like 1 Gene

Homo sapiens

Also known as OI16; OASIS

Gene ID: 90993 | Gene type: protein coding

About CREB3L1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,277,662-46,321,409 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 72 phenotypes. Broad expression in stomach (RPKM 29.2), colon (RPKM 23.7) and 16 other tissues.

Summary

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

CREB3L1 Products(1)

mRNA	Protein	Name
NM_052854.4	NP_443086.1	cyclic AMP-responsive element-binding protein 3-like protein 1

CREB3L1 Protein Structure

bZIP_1

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 1

BBF-2 homolog

Recombinant CREB3L1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76284	CREB3L1 Protein, Human (HEK293, His)	Q96BA8 (E396-S519)	≥95%

Related Diseases

Diseases

Alias

Osteogenesis Imperfecta, Type Xvi

Osteogenesis Imperfecta Type 16	OI16
Oi, Type Xvi	Osteogenesis Imperfecta Type Xvi
Chromosome 11p11.2 Deletion Syndrome 91.3-Kb	Osteogenesis Imperfecta 16
Chromosome 11p11.2 Deletion Syndrome, 91.3-Kb

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Brittle Bone Disorder

Osteogenesis Imperfecta	Brittle Bone Disease
Fragilitas Ossium	Osteopsathyrosis
Lobstein Disease	Oi
Vrolik Disease	Lobstein'S Disease
Lobstein'S Syndrome	Vrolik'S Disease
Porak And Durante Disease	Glass Bone Disease
Osteogenesis Imperfecta, Dominant Perinatal Lethal	Osteogenesis Imperfecta, Recessive Perinatal Lethal
Brittle Bone Syndrome	Oi - [Osteogenesis Imperfecta]
Ossium Fragility	Osteitis Fragilitans
Bony Fragility	Blue Sclera With Fragility Of Bone And Deafness
White Blue Sclera - Fragility Of Bone - Deafness

Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii	OI3
Oi, Type Iii	Osteogenesis Imperfecta Type 3
Oi Type Iii	Oi Type 3
Progressive Deforming Osteogenesis Imperfecta	Severe Osteogenesis Imperfecta
Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae	Progressively Deforming Osteogenesis Imperfecta With Normal Sclera
Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae	Progressively Deforming Oi
Osteogenesis Imperfecta 3	Oi-Iii
Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Dentinogenesis Imperfecta

Hereditary Opalescent Dentin	Dentinogenesis Imperfecta Without Osteogenesis Imperfecta
Dgi	Capdepont Teeth
Dgi Without Oi	Di
Non-Syndromic Dgi	Non-Syndromic Dentinogenesis Imperfecta
Opalescent Teeth Without Oi	Opalescent Teeth Without Osteogenesis Imperfecta
Opalescent Dentin

Small Cell Osteogenic Sarcoma

Small Cell Osteosarcoma	Round Cell Osteosarcoma
Osteosarcoma Small Cell

Osteogenesis Imperfecta, Type Xix

OI19	Osteogenesis Imperfecta Type 19
Osteogenesis Imperfecta Type Xix	Osteogenesis Imperfecta, Type 19
Osteogenesis Imperfecta 19

Keratosis Follicularis Spinulosa Decalvans

Kfsd	Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi
Keratosis Follicularis Spinulosa Decalvans, X-Linked	Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Keratosis Pilaris Atrophicans

KPA	Burnett Schwartz Berberian Syndrome

Cole-Carpenter Syndrome

Cole Carpenter Syndrome	Bone Fragility Craniosynostosis Proptosis Hydrocephalus
Bone Fragility With Craniosynostosis, Ocular Proptosis, Hydrocephalus, And Distinctive Facial Features	Bone Fragility-Craniosynostosis-Proptosis-Hydrocephalus Syndrome

Sarcomatosis

Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

PLSD-T	PLSDT
Platyspondylic Dysplasia, Torrance Type	Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type
Thanatophoric Dysplasia, Torrance Variant	Platyspondylic Skeletal Dysplasia, Torrance Type
Torrance Type Platyspondylic Dysplasia	Platyspondylic Dysplasia, Torrance-Luton Type
Platyspondylic Lethal Skeletal Dysplasia Torrance Type	Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type
Thanatophoric Dysplasia Torrance Variant	Platyspondylic Chondrodysplasia, Torrance-Luton Type
Plsd-Tl	Dysplasia, Skeletal, Platyspondylic, Torrance Type

Conventional Osteosarcoma

Intracortical Osteosarcoma	Conventional Central Osteosarcoma
Intracortical Osteogenic Sarcoma	Medullary Osteosarcoma

Spindle Cell Liposarcoma

Pseudosarcomatous Fibromatosis

Nodular Fasciitis	Pseudosarcomatous Fasciitis
Fasciitis - Nodular	Fasciitis Nodular

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Adult Fibrosarcoma

Osteogenesis Imperfecta, Type Xiv

Osteogenesis Imperfecta Type 14	OI14
Osteogenesis Imperfecta Type Xiv	Oi, Type Xiv
Osteogenesis Imperfecta 14	Oi Type Xiv
Oi-Xiv

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Bruck Syndrome

Osteogenesis Imperfecta With Congenital Joint Contractures

Osteogenesis Imperfecta-Congenital Joint Contractures Syndrome

Spondyloepiphyseal Dysplasia Congenita

SEDC	Sed Congenita
Spondyloepiphyseal Dysplasia, Congenital Type	Late Spondyloepiphyseal Dysplasia
Sed, Congenital Type	Congenital Spondyloepiphyseal Dysplasia
Spranger-Wiedemann Disease	Spondyloepiphyseal Dysplasia Congenital Type
Dysplasia, Spondyloepiphyseal, Congenita	Spondyloepiphyseal Dysplasia, Congenita
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I	OI1
Oi, Type I	Osteogenesis Imperfecta Tarda
Osteogenesis Imperfecta With Blue Sclerae	Osteogenesis Imperfecta Type 1
Adair-Dighton Syndrome	Mild Osteogenesis Imperfecta
Non-Deforming Osteogenesis Imperfecta	Oi Type 1
Van Der Hoeve Syndrome	Classic Non-Deforming Oi With Blue Sclerae
Osteogenesis Imperfecta 1	Oi-I
Osteopenic Non-Fracture Syndrome	Osteogenesis Imperfecta, Mild
Osteogenesis Imperfecta	Lobstein'S Disease

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03150	CREB3L1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CREB3L1	MGD	MGI:1347062
Bos taurus	CREB3L1	VGNC	VGNC:27694
Felis catus	CREB3L1	VGNC	VGNC:61166
Rattus norvegicus	CREB3L1	RGD	RGD:1359613
Canis familiaris	CREB3L1	VGNC	VGNC:39597
Macaca mulatta	CREB3L1	VGNC	VGNC:71438
Others	CREB3L1	NCBI

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