CREB3L1 - cAMP responsive element binding protein 3 like 1 Gene

Also Known as OI16; OASIS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 90993

About CREB3L1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,277,662-46,321,409 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 72 phenotypes. Broad expression in stomach (RPKM 29.2), colon (RPKM 23.7) and 16 other tissues.

Summary

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

CREB3L1 Products (1)

mRNA	Protein	Name
NM_052854.4	NP_443086.1	cyclic AMP-responsive element-binding protein 3-like protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	27121396	GOA
enables SMAD binding	IPI IPI: Inferred from physical interaction	25310401	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	27121396	GOA
involved in negative regulation of fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	27121396	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	27121396	GOA
involved in negative regulation of sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	27121396	GOA
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	25310401	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	27121396	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16236796	GOA
located in membrane	IDA IDA: Inferred from direct assay	25310401	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25310401	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREB3L1 Protein Structure

bZIP_1

0
100
200
300
400
519 a.a.

Protein Preferred Names	Protein Names
cyclic AMP-responsive element-binding protein 3-like protein 1	BBF-2 homolog

CREB3L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CREB3L1	Q96BA8	TMEM218	Homo sapiens	A2RU14	Y2H Array	29892012
Intra	CREB3L1	Q96BA8	TMEM218	Homo sapiens	A2RU14	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	GPR25	Homo sapiens	O00155	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	GPR25	Homo sapiens	O00155	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	GPR25	Homo sapiens	O00155	Y2H Array	25416956
Intra	CREB3L1	Q96BA8	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	25416956
Intra	CREB3L1	Q96BA8	NRM	Homo sapiens	Q8IXM6	Y2H Array	25416956
Intra	CREB3L1	Q96BA8	NRM	Homo sapiens	Q8IXM6	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	NRM	Homo sapiens	Q8IXM6	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	CCL4L1	Homo sapiens	Q8NHW4	Y2H Array	32296183
Intra	CREB3L1	Q96BA8	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	SLC35B4	Homo sapiens	Q969S0	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	MARCHF2	Homo sapiens	Q9P0N8	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	ADGRE2	Homo sapiens	Q9UHX3	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	MGST2	Homo sapiens	Q99735	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TLCD1	Homo sapiens	Q96CP7	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	CFHR5	Homo sapiens	Q9BXR6	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	ARV1	Homo sapiens	Q9H2C2	Y2H Array	32296183
Intra	CREB3L1	Q96BA8	ARV1	Homo sapiens	Q9H2C2	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TNMD	Homo sapiens	Q9H2S6-2	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	MAN2B2	Homo sapiens	Q9Y2E5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	SLC35A4	Homo sapiens	Q96G79	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	CNIH2	Homo sapiens	Q6PI25	Y2H Array	32296183
Intra	CREB3L1	Q96BA8	AQP10	Homo sapiens	Q96PS8	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TMEM208	Homo sapiens	Q9BTX3	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	SLC52A1	Homo sapiens	Q9NWF4	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	SEMA4G	Homo sapiens	Q9NTN9-2	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	PLPPR2	Homo sapiens	Q96GM1	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	FETUB	Homo sapiens	Q9UGM5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	AGPAT4	Homo sapiens	Q9NRZ5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TMEM14A	Homo sapiens	Q9Y6G1	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	AGPAT3	Homo sapiens	Q9NRZ7	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	C11orf24	Homo sapiens	Q96F05	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	NAT8	Homo sapiens	Q9UHE5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	NAT8	Homo sapiens	Q9UHE5	Y2H Array	32296183
Intra	CREB3L1	Q96BA8	FAM3C	Homo sapiens	Q92520	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	FAM3C	Homo sapiens	Q92520	Y2H Array	25416956
Intra	CREB3L1	Q96BA8	TECR	Homo sapiens	Q9NZ01	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TMEM222	Homo sapiens	Q9H0R3	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TMEM147	Homo sapiens	Q9BVK8	Y2H Array	25416956
Intra	CREB3L1	Q96BA8	TMEM147	Homo sapiens	Q9BVK8	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	CREB3L1	Q96BA8	SACM1L	Homo sapiens	Q9NTJ5	Complementation	32296183
Intra	CREB3L1	Q96BA8	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	MFSD5	Homo sapiens	Q6N075	Y2H Array	25416956
Intra	CREB3L1	Q96BA8	MFSD5	Homo sapiens	Q6N075	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	MFSD5	Homo sapiens	Q6N075	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	NAPB	Homo sapiens	Q9H115	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	ALG8	Homo sapiens	Q9BVK2	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	UNC93B1	Homo sapiens	Q9H1C4	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	GOLT1B	Homo sapiens	Q9Y3E0	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	CLN6	Homo sapiens	Q9NWW5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	VKORC1	Homo sapiens	Q9BQB6	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TSPO	Homo sapiens	P30536	Y2H Array	31515488
Intra	CREB3L1	Q96BA8	TSPO	Homo sapiens	P30536	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	AGPAT5	Homo sapiens	Q9NUQ2	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	NEU1	Homo sapiens	Q99519	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	CMTM3	Homo sapiens	Q96MX0	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	CIAO2A	Homo sapiens	Q9H5X1	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	CREB3L3	Homo sapiens	Q68CJ9	FRET	23661758
Intra	CREB3L1	Q96BA8	C5	Homo sapiens	P01031	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	C5	Homo sapiens	P01031	Y2H Array	25416956
Intra	CREB3L1	Q96BA8	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	TMEM234	Homo sapiens	Q8WY98	Y2H Prey Pooling	25416956
Intra	CREB3L1	Q96BA8	TMEM234	Homo sapiens	Q8WY98	Validated Y2H	25416956
Intra	CREB3L1	Q96BA8	DOLK	Homo sapiens	Q9UPQ8	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	CREB3L1	Q96BA8	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CREB3L1 Proteins

Cat. No.	상품명	Accession	Purity
HY-P76284	CREB3L1 Protein, Human (HEK293, His)	Q96BA8-1 (E396-S519)	≥ 95%, as determined by reducing SDS-PAGE.

CREB3L1 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P811353	CREB3L1 Antibody	WB, IHC-P, FC	Human, Mouse

Related Diseases

Diseases	Alias
Osteogenesis Imperfecta, Type Xvi	Osteogenesis Imperfecta Type 16 OI16 Oi, Type Xvi Osteogenesis Imperfecta Type Xvi Chromosome 11p11.2 Deletion Syndrome 91.3-Kb Osteogenesis Imperfecta 16 Chromosome 11p11.2 Deletion Syndrome, 91.3-Kb
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Osteogenesis Imperfecta, Type Iii	Osteogenesis Imperfecta Type Iii OI3 Oi, Type Iii Osteogenesis Imperfecta Type 3 Oi Type Iii Oi Type 3 Progressive Deforming Osteogenesis Imperfecta Severe Osteogenesis Imperfecta Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae Progressively Deforming Osteogenesis Imperfecta With Normal Sclera Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae Progressively Deforming Oi Osteogenesis Imperfecta 3 Oi-Iii Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Kidney Fibrosarcoma	Fibrosarcoma Of The Kidney
Dentinogenesis Imperfecta	Hereditary Opalescent Dentin Dentinogenesis Imperfecta Without Osteogenesis Imperfecta Dgi Capdepont Teeth Dgi Without Oi Di Non-Syndromic Dgi Non-Syndromic Dentinogenesis Imperfecta Opalescent Teeth Without Oi Opalescent Teeth Without Osteogenesis Imperfecta Opalescent Dentin
Small Cell Osteogenic Sarcoma	Small Cell Osteosarcoma Round Cell Osteosarcoma Osteosarcoma Small Cell
Osteogenesis Imperfecta, Type Xix	OI19 Osteogenesis Imperfecta Type 19 Osteogenesis Imperfecta Type Xix Osteogenesis Imperfecta, Type 19 Osteogenesis Imperfecta 19
Keratosis Follicularis Spinulosa Decalvans	Kfsd Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi Keratosis Follicularis Spinulosa Decalvans, X-Linked Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant
Keratosis Pilaris Atrophicans	KPA Burnett Schwartz Berberian Syndrome
Cole-Carpenter Syndrome	Cole Carpenter Syndrome Bone Fragility Craniosynostosis Proptosis Hydrocephalus Bone Fragility With Craniosynostosis, Ocular Proptosis, Hydrocephalus, And Distinctive Facial Features Bone Fragility-Craniosynostosis-Proptosis-Hydrocephalus Syndrome
Sarcomatosis
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type	PLSD-T PLSDT Platyspondylic Dysplasia, Torrance Type Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type Thanatophoric Dysplasia, Torrance Variant Platyspondylic Skeletal Dysplasia, Torrance Type Torrance Type Platyspondylic Dysplasia Platyspondylic Dysplasia, Torrance-Luton Type Platyspondylic Lethal Skeletal Dysplasia Torrance Type Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type Thanatophoric Dysplasia Torrance Variant Platyspondylic Chondrodysplasia, Torrance-Luton Type Plsd-Tl Dysplasia, Skeletal, Platyspondylic, Torrance Type
Conventional Osteosarcoma	Intracortical Osteosarcoma Conventional Central Osteosarcoma Intracortical Osteogenic Sarcoma Medullary Osteosarcoma
Spindle Cell Liposarcoma
Pseudosarcomatous Fibromatosis	Nodular Fasciitis Pseudosarcomatous Fasciitis Fasciitis - Nodular Fasciitis Nodular
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Adult Fibrosarcoma
Osteogenesis Imperfecta, Type Xiv	Osteogenesis Imperfecta Type 14 OI14 Osteogenesis Imperfecta Type Xiv Oi, Type Xiv Osteogenesis Imperfecta 14 Oi Type Xiv Oi-Xiv
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Bruck Syndrome	Osteogenesis Imperfecta With Congenital Joint Contractures Osteogenesis Imperfecta-Congenital Joint Contractures Syndrome
Spondyloepiphyseal Dysplasia Congenita	SEDC Sed Congenita Spondyloepiphyseal Dysplasia, Congenital Type Late Spondyloepiphyseal Dysplasia Sed, Congenital Type Congenital Spondyloepiphyseal Dysplasia Spranger-Wiedemann Disease Spondyloepiphyseal Dysplasia Congenital Type Dysplasia, Spondyloepiphyseal, Congenita Spondyloepiphyseal Dysplasia, Congenita Spondyloepiphyseal Dysplasia Tarda, X-Linked
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Osteogenesis Imperfecta, Type I	Osteogenesis Imperfecta Type I OI1 Oi, Type I Osteogenesis Imperfecta Tarda Osteogenesis Imperfecta With Blue Sclerae Osteogenesis Imperfecta Type 1 Adair-Dighton Syndrome Mild Osteogenesis Imperfecta Non-Deforming Osteogenesis Imperfecta Oi Type 1 Van Der Hoeve Syndrome Classic Non-Deforming Oi With Blue Sclerae Osteogenesis Imperfecta 1 Oi-I Osteopenic Non-Fracture Syndrome Osteogenesis Imperfecta, Mild Osteogenesis Imperfecta Lobstein'S Disease
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS03150	CREB3L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17784	Creb3l1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24251	Creb3l1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CREB3L1	MGD	MGI:1347062
Bos taurus	CREB3L1	VGNC	VGNC:27694
Felis catus	CREB3L1	VGNC	VGNC:61166
Rattus norvegicus	CREB3L1	RGD	RGD:1359613
Canis familiaris	CREB3L1	VGNC	VGNC:39597
Macaca mulatta	CREB3L1	VGNC	VGNC:71438
Others	CREB3L1	NCBI