HDAC-IN-26

ADC Targets in Oncology

2026-04-10

Cell Line	Type	Value	Description	References
Jurkat	EC₅₀	4.7 nM Compound: 10	Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by Steady-Glo luciferase assay Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by Steady-Glo luciferase assay	[PMID: 32676157]
Sf9	IC₅₀	>50 μM Compound: 10	Inhibition of human recombinant full length N-terminal GST-tagged HDAC5 expressed in baculovirus infected sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence Inhibition of human recombinant full length N-terminal GST-tagged HDAC5 expressed in baculovirus infected sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence	[PMID: 32676157]
Sf9	IC₅₀	>50 μM Compound: 10	Inhibition of human recombinant untagged HDAC11 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay Inhibition of human recombinant untagged HDAC11 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay	[PMID: 32676157]
Sf9	IC₅₀	0.47 nM Compound: 10	Inhibition of full length human recombinant FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 cells using FLUOR DE LYS as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay Inhibition of full length human recombinant FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 cells using FLUOR DE LYS as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay	[PMID: 32676157]

Cell Line

Type

Value

Description

References

Jurkat

EC₅₀

4.7 nM

Compound: 10

Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by Steady-Glo luciferase assay

[PMID: 32676157]

Sf9

IC₅₀

>50 μM

Compound: 10

Inhibition of human recombinant full length N-terminal GST-tagged HDAC5 expressed in baculovirus infected sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence

[PMID: 32676157]

Sf9

IC₅₀

>50 μM

Compound: 10

Inhibition of human recombinant untagged HDAC11 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay

[PMID: 32676157]

Sf9

IC₅₀

0.47 nM

Compound: 10

Inhibition of full length human recombinant FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 cells using FLUOR DE LYS as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay

[PMID: 32676157]

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HDAC-IN-26

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HDAC-IN-26 Related Classifications

HY-145350 Related Classifications