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Cat. No.: HY-162781

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HDAC1/6-IN-2

HDAC1/6-IN-2 (I-c4) is the inhibitor of HDAC1 and HDAC6, with the IC₅₀s of 3.1 nM and 2.95 nM, respectively. HDAC1/6-IN-2 has antitumor activity.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₇FN₄O₃
Molecular Weight:404.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

HDAC1/6-IN-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

HDAC1/6-IN-2 (I-c4) is the inhibitor of HDAC1 and HDAC6, with the IC₅₀s of 3.1 nM and 2.95 nM, respectively. HDAC1/6-IN-2 has antitumor activity^[1].

IC₅₀ & Target

HDAC6

2.95 nM (IC₅₀)

HDAC1

3.1 nM (IC₅₀)

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	>10 μM Compound: I-c4	Antiproliferative activity against human AGS cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human AGS cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
BGC-823	IC₅₀	2.25 μM Compound: I-c4	Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
HCT-116	IC₅₀	>10 μM Compound: I-c4	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
HGC-27	IC₅₀	2.8 μM Compound: I-c4	Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
MGC-803	IC₅₀	0.95 μM Compound: I-c4	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
MKN-45	IC₅₀	7.43 μM Compound: I-c4	Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
NCI-H460	IC₅₀	>10 μM Compound: I-c4	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
PANC-1	IC₅₀	3.79 μM Compound: I-c4	Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
PC-3	IC₅₀	>10 μM Compound: I-c4	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
SGC-7901	IC₅₀	8.34 μM Compound: I-c4	Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
SMMC-7721	IC₅₀	2.74 μM Compound: I-c4	Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]
TE-1	IC₅₀	4.5 μM Compound: I-c4	Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth by MTT assay	[PMID: 39102466]

Chemical Information

Molecular Weight 404.39
Formula C₂₂H₁₇FN₄O₃
SMILES

O=C(C1=CC(C2=CC=C(C=C2)F)=CN3C1=NC=C3)NCC4=CC=C(C=C4)C(NO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fei-Fei Yang, et al. Discovery of Novel Imidazo[1,2-a]pyridine-Based HDAC6 Inhibitors as an Anticarcinogen with a Cardioprotective Effect. J Med Chem. 2024 Aug 22;67(16):14345-14369. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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