2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. CDK Wnt
  4. Ipivivint

Ipivivint (Compound 38) is an orally active and potent CDC-like kinase (CLK) inhibitor with EC50 of 1 nM and 7 nM for CLK2 (human) and CLK3 (human), respectively. Ipivivint also inhibits the Wnt pathway (EC50=13 nM) and tyrosine phosphorylation-regulated kinase 1A (human) (EC50=5 nM).

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Ipivivint

Ipivivint 構造式

CAS 番号 : 1481617-15-5

容量 価格（税別） 在庫状況 数量
5 mg $480 在庫あり
10 mg $770 在庫あり
25 mg $1550 在庫あり
50 mg $2550 在庫あり
100 mg $4150 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Ipivivint 関連抗体

Top Publications Citing Use of Products

CDK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

Wnt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

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製品説明

Ipivivint (Compound 38) is an orally active and potent CDC-like kinase (CLK) inhibitor with EC50 of 1 nM and 7 nM for CLK2 (human) and CLK3 (human), respectively. Ipivivint also inhibits the Wnt pathway (EC50=13 nM) and tyrosine phosphorylation-regulated kinase 1A (human) (EC50=5 nM)[1][2].

IC50 & Target[1]

CDK2

1 nM (EC50)

CDK3

7 nM (EC50)

体外実験

Ipivivint 関連抗体

Western Blot Analysis[1]

Cell Line: SW480 cells
Concentration: 0.01~10 μM
Incubation Time: 1 hour
Result: Potently inhibited SRSF5/6 phosphorylation.

Apoptosis Analysis[1]

Cell Line: SW480 cells
Concentration: 0.01~10 μM
Incubation Time: 0.03 μM~3 μM
Result: Induced apoptosis.

RT-PCR[1]

Cell Line: HEK-293T cells
Concentration: 0.3~3 μM
Incubation Time: 1 hour
Result: Inhibited Wnt/β-catenin signaling induced by Wnt3a.

Immunofluorescence[1]

Cell Line: SW480 cells
Concentration: 0.3~10 μM
Incubation Time: 6 hours
Result: Increased nuclear speckle enlargement.
体内実験
Animal Model: Foxn1 mice[1]
Dosage: 25 mg/kg
Administration: P.o.
Result: Potently inhibited tumor SRSF6 phosphorylation.
臨床実験
分子量

464.50

分子式

C26H21FN8
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN(C)CC1=CC(C2=CN=C(NN=C3C(N4)=NC5=C4C(C6=CC(F)=CC=C6)=CN=C5)C3=C2)=CN=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 3.33 mg/mL (7.17 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1529 mL 10.7643 mL 21.5285 mL
5 mM 0.4306 mL 2.1529 mL 4.3057 mL
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1529 mL 10.7643 mL 21.5285 mL 53.8213 mL
5 mM 0.4306 mL 2.1529 mL 4.3057 mL 10.7643 mL
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Ipivivint Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ipivivint1481617-15-5CDKWntCyclin dependent kinaseCLK2CLK3Inhibitorinhibitorinhibit

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製品名:
Ipivivint
製品番号:
HY-137443
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