Albanol B
Based on 1 Customer Validation
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2.
For research use only. We do not sell to patients.
- Purity : 99.79%
- CAS No.: 87084-99-9
- Formula: C34H22O8
- Molecular Weight:558.53
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Albanol B (10 μM, 30 μM; 24 h) decreases cell viability of A549 cells[1].
Albanol B (30 μM; 48 h) arrrests cell cycle at G2/M phase and induces apoptosis in A549 and H1975 cells[1].
Albanol B (1-30 μM; 1-9 h) mediates the activation of ERK-1/2 and AKT in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells, BZR, NCI-H1975, and NCI-H226 cells
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Concentration:0, 1, 3, 10, and 30 μM
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Incubation Time:48 hours
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Result:Exhibited inhibitory effects on cancer cells with IC50s of 5.6 μM (A549), 8.9 μM (BZR), 12.7 μM (NCI-H1975), and 15 μM (NCI-H226), respectively.
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Cell Line:A549 and H1975 cells
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Concentration:1, 3, 10 μM
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Incubation Time:48 hours
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Result:Increased cells in G2/M phase from 9.5% to 14.34%, 18.13% and 47.9%, respectively.
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Cell Line:A549 cells
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Concentration:1 h, 3 h, 6 h, and 9 h
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Incubation Time:48 hours
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Result:Increased the phosphorylation levels of ERK1/2 and AKT in time- and concentration-dependent manners.
Did not increase the phosphorylation level of JNK and p38 MAPKs.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:EX-3LL tumor-bearing mice[1]
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Dosage:50 mg/kg, 100 mg/kg
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Administration:IP; once daily for 21 days
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Result:Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively.
Chemical Information
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CAS No. 87084-99-9
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Appearance Solid
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Molecular Weight 558.53
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Formula C34H22O8
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Color Off-white to gray
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SMILES
OC1=C(C=CC(O)=C1)[C@@]23C4=C(C5=CC=C(O)C=C5O3)C=C(C)C=C4C6=C(O)C=C(C(OC7=C8)=CC7=CC=C8O)C=C6O2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Albanol B Related Classifications
HY-N11439 Related Classifications
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