MC4491
MC4491 is a selective LSD1/PRMT5 inhibitor, with an IC50 of 0.152 μM against the LSD1/CoREST complex and an IC50 of 0.043 μM against the PRMT5/MEP50 complex. MC4491 induces transcriptomic changes and splicing alterations in AML cells. MC4491 is applicable for the research of acute myeloid leukemia.
For research use only. We do not sell to patients.
- Formula: C35H45N7O3
- Molecular Weight:611.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
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LSD1 0.152 μM (IC50) |
PRMT5 0.043 μM (IC50) |
MC4491 potently and selectively inhibits both LSD1/CoREST (IC50 = 0.152 μM) and PRMT5/MEP50 (IC50 = 0.043 nM) in biochemical assays, with minimal activity against PRMT1 and PRMT7[1].
MC4491 (50 nM; 3 days) treatment of MV4-11 AML cells recapitulates the transcriptomic and alternative splicing changes induced by combined PRMT5 and LSD1 inhibition, including activation of myeloid differentiation pathways and suppression of cell cycle-related pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 611.78
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Formula C35H45N7O3
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SMILES
NC1CC1C2=CC=C(C=C2)NC(CCN3CCC(CC3)NC4=CC(C(NC[C@@H](CN5CCC6=CC=CC=C6C5)O)=O)=CC=N4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MC4491 Related Classifications
HY-182892 Related Classifications
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