RWT9996
RWT9996 is a GPR17 antagonist. RWT9996 inhibits GPR17-mediated signal transduction processes, including G protein activation and β-arrestin-2 recruitment. RWT9996 inhibits MDL-29951 (HY-16312)-mediated phosphorylation of ERK1/2, phosphorylation of CREB, and accumulation of inositol phosphate (IP1) in oligodendrocyte precursor cells in vitro. RWT9996 can be used in studies related to demyelinating diseases.
For research use only. We do not sell to patients.
- CAS No.: 2877694-62-5
- Formula: C17H12FN3O2S
- Molecular Weight:341.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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ERK1 |
ERK2 |
Arrestin-3/β-Arrestin 2 |
RWT9996 (12 min) potently inhibits MDL-29951-mediated activation of Gαi2, Gαz and Gα12 in FlpIn-HEK293-hGPR17S cells, with pKB values ranging from 7.7 to 8.3, but induces non-specific effects[1].
RWT9996 potently inhibits MDL-29951-mediated recruitment of β-arrestin-2 to GPR17 in HEK293T cells[1].
RWT9996 (pre-incubated for 10 min, stimulated for 2 min) potently inhibits ERK1/2 phosphorylation in differentiated Oli-neu cells with a pIC50 value of 8.2; it potently inhibits the first phase of CREB phosphorylation induced by MDL-29951 (HY-16312) with a pIC50 of 8.1; and it inhibits IP1 accumulation with a pIC50 of 7.0, where this accumulation is slightly enhanced by Barbadin (HY-119706)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2877694-62-5
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Molecular Weight 341.36
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Formula C17H12FN3O2S
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SMILES
FC1=C(NS(C2=CNC(C3=CC=CC=C3)=C2)(=O)=O)C=CC(C#N)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RWT9996 Related Classifications
HY-179606 Related Classifications
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