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Cat. No.: HY-173257

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Cath-L-dBET1

Cath-L-dBET1 is a PROTAC degrader targeting BRD4. Cath-L-dBET1 has an IC₅₀ value of 2.8 μM in MDA-MB-231 cells. Cath-L-dBET1 can be activated by cathepsin L (Cath-L) and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study.
(Pink: BRD4 ligand (HY-178094); Blue: Cereblon ligand (HY-103597); Black: linker (HY-178092)).

For research use only. We do not sell to patients.

Formula: C₅₈H₆₆ClN₁₁O₁₁S
Molecular Weight:1160.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Cath-L-dBET1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cath-L-dBET1 is a PROTAC degrader targeting BRD4. Cath-L-dBET1 has an IC₅₀ value of 2.8 μM in MDA-MB-231 cells. Cath-L-dBET1 can be activated by cathepsin L (Cath-L) and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study^[1]. (Pink: BRD4 ligand (HY-178094); Blue: Cereblon ligand (HY-103597); Black: linker (HY-178092)).

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

Anti-cancerOthers

Anti-cancer

DAO-dBET1 (1 μM; 72 h) induces apoptosis and activates Caspase 3/7 activity in hypoxic, cathepsin L-activated MDA-MB-231 cells^[1].
DAO-dBET1 (0.1 nM-10 μM; 72 h) exhibits cytotoxic activity by inhibiting cell viability in MDA-MB-231 cells with hypoxia and cathepsin L activity^[1].

Others

DAO-dBET1 (0.05-5.0 μM; 24 h) induces BRD4 protein degradation in MDA-MB-231, HeLa and HEK-293 cells (under hypoxic conditions with active cathepsin L), while it barely induces BRD4 protein degradation under normoxic conditions with inhibited cathepsin L activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1160.73
Formula C₅₈H₆₆ClN₁₁O₁₁S
SMILES

CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(NCCCCN(C(COC4=C5C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)=CC=C4)=O)CC7=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)C=C7)=O)=C(S1)N8C3=NN=C8C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dutta R, et al. Dual-Action-Only PROTACs. J Am Chem Soc. 2025 Mar 19;147(11):9074-9078. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Cath-L-dBET1

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms