UNC7242
UNC7242 is an antagonist that binds to the Tudor domains of PHF1 and PHF19, with a Kd of 1.13 μM for PHF1 and 0.64 μM for PHF19. UNC7242 fails to displace full-length PHF1 or PHF19 from H3K36me3 nucleosomes or chromatin. UNC7242 can be used in studies related to multiple myeloma, endometrial stromal sarcoma, and ossifying fibromyxoid tumor.
For research use only. We do not sell to patients.
- Formula: C19H25ClN4O2
- Molecular Weight:376.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
UNC7242 binds to the isolated PHF1 Tudor domain with a Kd value of 1.13 ± 0.04 μM, and binds to the isolated PHF19 Tudor domain with a Kd value of 0.64 ± 0.14 μM[1].
UNC7242 (100 μM; 2 h) does not significantly displace endogenous PHF19 from chromatin in Jurkat N6 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 376.88
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Formula C19H25ClN4O2
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SMILES
COC1=CC2=NC(Cl)=NC(N3CCCN(CC3)CC4CC4)=C2C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC7242 Related Classifications
HY-181914 Related Classifications
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