製品番号: HY-12956

プロスタグランジン F2α

(別名: PGF2α; Dinoprost; Prostaglandin F2α)

9 Cited Publications

カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.84%
CAS 番号: 551-11-1
分子式: C₂₀H₃₄O₅
分子量:354.48

保管条件:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Dinoprost 構造式

CAS 番号: 551-11-1

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 臨床実験
化学情報
Publications (9)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]^[2]

FP Receptor

Human Endogenous Metabolite

Prostaglandin Receptor アイソフォーム固有の製品をすべて表示 :

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	>10000 nM Compound: PGF2	Affinity for Prostanoid EP2 receptor expressed in CHO cells Affinity for Prostanoid EP2 receptor expressed in CHO cells	[PMID: 10715159]
CHO	IC₅₀	>10000 nM Compound: PGF2	Affinity for Prostanoid TP receptor expressed in CHO cells Affinity for Prostanoid TP receptor expressed in CHO cells	[PMID: 10715159]
CHO	IC₅₀	322 nM Compound: PGF2	Affinity for Prostanoid EP3 receptor expressed in CHO cell line Affinity for Prostanoid EP3 receptor expressed in CHO cell line	[PMID: 10715159]
CHO	IC₅₀	4200 nM Compound: PGF2	Affinity for Prostanoid EP4 receptor expressed in CHO cells Affinity for Prostanoid EP4 receptor expressed in CHO cells	[PMID: 10715159]
CHO	IC₅₀	>10000 nM Compound: PGF2	Affinity for Prostaglandin I2 receptor expressed in CHO cells Affinity for Prostaglandin I2 receptor expressed in CHO cells	[PMID: 10715159]
COS-7	IC₅₀	380 nM Compound: PGF2	Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. Affinity for Prostanoid EP1 receptor expressed in COS-7 cells.	[PMID: 10715159]
COS-7	IC₅₀	7 nM Compound: PGF2	Affinity for human Prostanoid FP receptor expressed in COS-7 cells Affinity for human Prostanoid FP receptor expressed in COS-7 cells	[PMID: 10715159]
HEK293	IC₅₀	4500 nM Compound: PGF2	Affinity for human Prostaglandin D2 receptor expressed in HEK293 cells Affinity for human Prostaglandin D2 receptor expressed in HEK293 cells	[PMID: 10715159]
K562	IC₅₀	>700 μM Compound: 1	In vitro antiproliferative activity was measured on human leukemia K562 cells In vitro antiproliferative activity was measured on human leukemia K562 cells	10.1016/S0960-894X(00)80372-8
NIH3T3	EC₅₀	24.5 nM Compound: PGF2 alpha	Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells	[PMID: 15357985]
NIH3T3	EC₅₀	24.5 nM Compound: PGF2alpha	Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting	[PMID: 19101156]
Oocyte	IC₅₀	0.287 μM Compound: Prostaglandin F2alpha	TP_TRANSPORTER: inhibition of PGD2 uptake in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of PGD2 uptake in Xenopus laevis oocytes	[PMID: 10973807]

体外実験

Dinoprost (Prostaglandin F2α; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells^[1].
Dinoprost (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

Goat luteal cells
Concentration:

1 μM
Incubation Time:

For 24 hours
Result:

Significantly increased the apoptotic rate (15.62±3.12%).

Cell Autophagy Assay^[1]

Cell Line:

Goat luteal cells
Concentration:

1 μM
Incubation Time:

For 24 hours
Result:

There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.

Western Blot Analysis^[1]

Cell Line:

Goat luteal cells
Concentration:

1 μM
Incubation Time:

For 24 hours
Result:

The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 551-11-1
性状 <25°C Solid,>35°C Liquid
分子量 354.48
分子式 C₂₀H₃₄O₅
Color White to light brown
SMILES

CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(O)=O
別名

PGF2α; Dinoprost; Prostaglandin F2α
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (9)

All Histological Imaging/StainingWBRT-PCRCell Imaging/Staining

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Journal Impact Factor

Cell Metab

Lipid-induced granules in hepatocytes alleviate liver fibrosis. [Abstract]

2026 Jan 9:S1550-4131(25)00546-7. PMID: 41519131
Nat Commun

Ligand-induced activation and G protein coupling of prostaglandin F2α receptor. [Abstract]

2023 May 9;14(1):2668. PMID: 37160891
Phytomedicine

Evodiamine inhibits NLRP3 inflammasome-mediated microglial pyroptosis and promotes remyelination via SLC2A4-regulated autophagy. [Abstract]

2025 May 14:143:156866. PMID: 40393245

Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]

Dinoprost (20 mg/kg/d for 10 days, intraperitoneally injected). Representative images of MBP and LFB staining (scale bar, 500 μm) (n = 6), and transmission electron microscopy (scale bar, 1 μm) (n = 6) in the corpus callosum region of different groups of mice.

Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]

Dinoprost (20 mg/kg/d for 10 days, intraperitoneally injected). Expression of SLC2A4 and MBP in the mouse corpus callosum determined and statistically analyzed by protein immunoblotting.

Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]

Dinoprost (20 mg/kg/d for 10 days, intraperitoneally injected). Expression of SLC2A4 and MBP in the mouse corpus callosum determined and statistically analyzed by real-time PCR.

Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]

LPS+ATP-induced pyroptosis treated with EVO (at different concentrations) and SLC2A4 inhibitor Dinoprost (PGF2α, 1 μM, 24 h) followed by eGFP-mCherry probe detection of autophagic flux (scale bar, 20 μm) and fluorescence detection of SLC2A4 (scale bar, 50 μm): LAMP1 (green), LC3B (red), and DAPI (blue) (scale bar, 50 μm).

Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]

Western blot analysis of pyroptotic proteins GSDMD, GSDMD-N, and NLRP3 inflammasome expression after LPS+ATP induced-pyroptosis, and EVO and SLC2A4 inhibitor Dinoprost (PGF2α, 1 μM, 24 h) treatment.

Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]

Expressions of autophagy-related proteins P62, Beclin1, and LC3B detected by western blot after LPS+ATP induced-pyroptosis, and EVO and SLC2A4 inhibitor PGF2α treatment.
Int J Mol Sci

Prostaglandin F2α Regulates Adipogenesis by Modulating Extracellular Signal-Regulated Kinase Signaling in Graves' Ophthalmopathy. [Abstract]

2023 Apr 10;24(8):7012. PMID: 37108173
ACS Pharmacol Transl Sci

Ultrasensitive Profiling of Arachidonic Acid Metabolites Based on 5‑(Diisopropylamino)amylamine Derivatization-Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. [Abstract]

2025 Oct 4;8(11):4095-4106. PMID: 41262585
Fitoterapia

2026 Mar 17.
Patent

US20260001892A1.
Patent

US20250250283A1.
Patent

US20250154162A1.

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (282.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8210 mL

14.1052 mL

28.2103 mL

5 mM

0.5642 mL

2.8210 mL

5.6421 mL

10 mM

0.2821 mL

1.4105 mL

2.8210 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
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COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hagen Thieme, et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. Invest Ophthalmol Vis Sci. 2006 Mar;47(3):938-45. [Content Brief]

[2]. Xin Wen, et al. Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy. Front Physiol. 2020 Sep 11;11:868. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8210 mL	14.1052 mL	28.2103 mL	70.5258 mL
	5 mM	0.5642 mL	2.8210 mL	5.6421 mL	14.1052 mL
	10 mM	0.2821 mL	1.4105 mL	2.8210 mL	7.0526 mL
	15 mM	0.1881 mL	0.9403 mL	1.8807 mL	4.7017 mL
	20 mM	0.1411 mL	0.7053 mL	1.4105 mL	3.5263 mL
	25 mM	0.1128 mL	0.5642 mL	1.1284 mL	2.8210 mL
	30 mM	0.0940 mL	0.4702 mL	0.9403 mL	2.3509 mL
	40 mM	0.0705 mL	0.3526 mL	0.7053 mL	1.7631 mL
	50 mM	0.0564 mL	0.2821 mL	0.5642 mL	1.4105 mL
	60 mM	0.0470 mL	0.2351 mL	0.4702 mL	1.1754 mL
	80 mM	0.0353 mL	0.1763 mL	0.3526 mL	0.8816 mL
	100 mM	0.0282 mL	0.1411 mL	0.2821 mL	0.7053 mL

Dinoprost

9 Cited Publications

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プロスタグランジン F2α

Apoptosis Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Natural Product Library

FDA-Approved Drug Library

Autophagy Compound Library

Human Endogenous Metabolite Compound Library

Drug Repurposing Compound Library

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Endocrinology Compound Library

Endoplasmic Reticulum Stress Compound Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

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Food-Sourced Compound Library

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FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Fatty Acids Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Lipid Metabolite Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

MedChemExpress（MCE）の使用を引用している文献 Dinoprost

Prostaglandin Receptor アイソフォーム固有の製品をすべて表示

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (9)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Dinoprost 関連分類

製品番号: HY-12956