製品番号: HY-B1467

ドミフェン臭化物

(別名: Domiphen (bromide); ドミフェンブロミド)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC₅₀: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.73%
CAS 番号: 538-71-6
分子式: C₂₂H₄₀BrNO
分子量:414.46

保管条件:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Domiphen bromide 構造式

CAS 番号: 538-71-6

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Amount: USD 0.00

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

Domiphen bromide (20 µM; 8-24 h) can inhibit the growth of Plasmodium falciparum, block the production of MEP, and simultaneously reduce the levels of multiple intermediates in the citric acid cycle and activate the glycolysis pathway^[1].
Domiphen bromide (0.01-10 μM; 0-18 h) can inhibit contraction parameters, prolong the field potential duration, and cause tachycardia/fibrillation-like oscillations in human induced pluripotent stem cell-derived cardiomyocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Domiphen bromide (1.28-12.85 mg/kg; intravenous injection; single dose) has certain cardiotoxicity in rabbits. Rabbits show good tolerance at a dose of 1.28 mg/kg^[2].
Domiphen bromide (20 mg/kg; intraperitoneal injection; single dose) in combination with Colistin (HY-113678) exhibits antibacterial activity in a mouse model infected with K. pneumonia FK6556^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SPF male New Zealand white rabbits (2.0-2.8 kg)^[2]
Dosage:

1.28, 3.85 and 12.85 mg/kg
Administration:

Intravenous injection; single dose
Result:

Evoked QTc prolongation, noncomplex arrhythmias and ventricular tachycardias at dose of 12.85 mg/kg.

化学情報

CAS 番号 538-71-6
性状 Solid
分子量 414.46
分子式 C₂₂H₄₀BrNO
Color White to off-white
SMILES

CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1.[Br-]
別名

Domiphen (bromide); ドミフェンブロミド
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Antioxidants (Basel)

Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species. [Abstract]

2024 May 29;13(6):667. PMID: 38929106

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (241.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (241.28 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4128 mL

12.0639 mL

24.1278 mL

5 mM

0.4826 mL

2.4128 mL

4.8256 mL

10 mM

0.2413 mL

1.2064 mL

2.4128 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (6.03 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 25 mg/mL (60.32 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
SDS (393 KB)
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- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Biosca A, et al. Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway. Pharmaceutics. 2022 Jun 22;14(7):1320. [Content Brief]

[2]. Long Y, et al. Proarrhythmic effects induced by benzethonium chloride and domiphen bromide in vitro and in vivo. Toxicol Appl Pharmacol. 2021 Nov 15;431:115731. [Content Brief]

[3]. Chen H, et al. Combining with domiphen bromide restores colistin efficacy against colistin-resistant Gram-negative bacteria in vitro and in vivo. Int J Antimicrob Agents. 2024 Feb;63(2):107066. [Content Brief]

[4]. Long Y, et al. Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide. Eur J Pharmacol. 2014 Aug 15;737:202-9. [Content Brief]

[5]. Mäkinen KK, et al. Selective effect of domiphen bromide (dodecyldimethyl(2-phenoxyethyl)ammonium bromide) on some hydrolytic enzymes. Biochim Biophys Acta. 1970 Apr 22;206(1):143-51. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	2.4128 mL	12.0639 mL	24.1278 mL	60.3195 mL
	5 mM	0.4826 mL	2.4128 mL	4.8256 mL	12.0639 mL
	10 mM	0.2413 mL	1.2064 mL	2.4128 mL	6.0319 mL
	15 mM	0.1609 mL	0.8043 mL	1.6085 mL	4.0213 mL
	20 mM	0.1206 mL	0.6032 mL	1.2064 mL	3.0160 mL
	25 mM	0.0965 mL	0.4826 mL	0.9651 mL	2.4128 mL
	30 mM	0.0804 mL	0.4021 mL	0.8043 mL	2.0106 mL
	40 mM	0.0603 mL	0.3016 mL	0.6032 mL	1.5080 mL
	50 mM	0.0483 mL	0.2413 mL	0.4826 mL	1.2064 mL
	60 mM	0.0402 mL	0.2011 mL	0.4021 mL	1.0053 mL
	80 mM	0.0302 mL	0.1508 mL	0.3016 mL	0.7540 mL
	100 mM	0.0241 mL	0.1206 mL	0.2413 mL	0.6032 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Domiphen bromide

1 Cited Publications

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ドミフェン臭化物

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MedChemExpress（MCE）の使用を引用している文献 Domiphen bromide

Parasite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Domiphen bromide 関連分類

HY-B1467 関連分類