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Doramapimod

(別名: BIRB 796)
52 Cited Publications
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Based on 52 publication(s) in Google Scholar

Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM.

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  • 純度: 99.93%
  • CAS 番号: 285983-48-4
  • 分子式: C31H37N5O3
  • 分子量:527.66
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Doramapimod Chemical Structure
    Doramapimod 構造式
  • Experimental Validation Results for Doramapimod
  • Experimental Validation Results for Doramapimod
  • Experimental Validation Results for Doramapimod
  • Experimental Validation Results for Doramapimod
  • Experimental Validation Results for Doramapimod
CAS 番号: 285983-48-4
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p38 MAPK アイソフォーム固有の製品をすべて表示

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  • Doramapimod Chemical Structure
    Doramapimod Chemical Structure
    1/16
  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Engineering. 2025 Mar 4.

    Customer Validation
     BIRB 796 (10 μM, 36 h) inhibited the expression of p-p38 MAPK induced by LPS (200 ng/mL) in THP-1 cells.

  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Oct:76:103344. [Abstract]

    Customer Validation
     BIRB 796 (DORA, 10 μM, 4 h) inhibited the expression of p-p38 MAPK induced by LPS (1000 ng/mL) in 10T1/2 cells.

  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Oct:76:103344. [Abstract]

    Customer Validation
     BIRB 796 (DORA, 10 μM, 4 h) inhibited the mitochondrial recruitment of DRP1 and the fission induced by LPS (1000 ng/mL) in 10T1/2 cells.

  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Cell Res. 2020 Jul;30(7):574-589. [Abstract]

    Customer Validation
     Birb 796 (0.1, 0.3, 1, and 3 μM, 3 days) impaired the ability of SSK1 (0.5 μM,3 days) to specifically kill senescent HUVEC.

  • 1/16

    Doramapimod purchased from MedChemExpress. Usage Cited in: Nature. 2019 Jul;571(7763):127-131. [Abstract]

    Customer Validation
     BIRB 796 (1 μM, 4.5 h) did not abrogate EGF-induced pUGDH in A549 cells stably expressing Flag–UGDH.

  • Doramapimod