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製品番号: HY-117047

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ALC67

ALC67 is a cytotoxic thiazolidine compound with an IC₅₀ of approximately 5 μM against liver, breast cancer, colon cancer, and endometrial cancer cell lines. ALC67 induces apoptosis in cancer cells by activating caspase-9 and causing cell cycle arrest at the SubG1/G1 phase, via a pathway that is independent of death receptors. ALC67 can be used in cancer research.

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CAS 番号: 1044255-57-3
分子式: C₁₅H₁₅NO₃S
分子量:289.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ALC67 構造式

CAS 番号: 1044255-57-3

容量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Caspase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-20	IC₅₀	1.6 μM Compound: 3, ALC67	Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
CAMA-1	IC₅₀	0.01 μM Compound: 3, ALC67	Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
HCT-116	IC₅₀	9.23 μM Compound: 3, ALC67	Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
HepG2	IC₅₀	10 μM Compound: 3, ALC67	Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
Huh-7	IC₅₀	5.3 μM Compound: 3, ALC67	Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
MCF7	IC₅₀	4.7 μM Compound: 3, ALC67	Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
MFE-296	IC₅₀	0.5 μM Compound: 3, ALC67	Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
T47D	IC₅₀	7.62 μM Compound: 3, ALC67	Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay	[PMID: 22867707]

化学情報

CAS 番号 1044255-57-3
分子量 289.35
分子式 C₁₅H₁₅NO₃S
SMILES

O=C([C@H]1N(C(C#C)=O)C(C2=CC=CC=C2)SC1)OCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Onen-Bayram FE, et al. A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells. Bioorg Med Chem. 2012 Sep 1;20(17):5094-102. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
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参考文献

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ALC67

Caspase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

ALC67 関連分類

HY-117047 関連分類