BRD9757
Based on 1 Customer Validation
BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.75%
- CAS 番号: 1423058-85-8
- 分子式: C6H9NO2
- 分子量:127.14
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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HDAC6 0.03 μM (IC50) |
HDAC1 0.638 μM (IC50) |
HDAC2 1.79 μM (IC50) |
HDAC3 0.694 μM (IC50) |
HDAC4 21.80 μM (IC50) |
HDAC5 18.32 μM (IC50) |
HDAC7 12.61 μM (IC50) |
HDAC8 1.09 μM (IC50) |
HDAC9 >33.33 μM (IC50) |
BRD9757 (compound 14) against HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, and HDAC9 with IC50 values of 0.638 μM, 1.79 μM, 0.694 μM, 21.80 μM, 18.32 μM, 12.61 μM, 1.09 μM, and >33.33 μM, respectively[1].
BRD9757 (compound 14; 10-30 μM; 24 h) selectively increases the level of Ac-tubulin, without increasing histone acetylation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:10 μM and 30 μM
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Incubation Time:for 24 h
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Result:Increased the level of Ac-tubulin.
化学情報
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CAS 番号 1423058-85-8
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性状 Solid
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分子量 127.14
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分子式 C6H9NO2
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Color Light yellow to khaki
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SMILES
O=C(C1=CCCC1)NO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : 12.5 mg/mL (98.32 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.8653 mL | 39.3267 mL | 78.6535 mL | 196.6336 mL |
| 5 mM | 1.5731 mL | 7.8653 mL | 15.7307 mL | 39.3267 mL | |
| 10 mM | 0.7865 mL | 3.9327 mL | 7.8653 mL | 19.6634 mL | |
| 15 mM | 0.5244 mL | 2.6218 mL | 5.2436 mL | 13.1089 mL | |
| 20 mM | 0.3933 mL | 1.9663 mL | 3.9327 mL | 9.8317 mL | |
| 25 mM | 0.3146 mL | 1.5731 mL | 3.1461 mL | 7.8653 mL | |
| 30 mM | 0.2622 mL | 1.3109 mL | 2.6218 mL | 6.5545 mL | |
| 40 mM | 0.1966 mL | 0.9832 mL | 1.9663 mL | 4.9158 mL | |
| 50 mM | 0.1573 mL | 0.7865 mL | 1.5731 mL | 3.9327 mL | |
| 60 mM | 0.1311 mL | 0.6554 mL | 1.3109 mL | 3.2772 mL | |
| 80 mM | 0.0983 mL | 0.4916 mL | 0.9832 mL | 2.4579 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BRD9757 関連分類
HY-117554 関連分類
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