Cinuperone
Cinuperone is a multi-target competitive receptor ligand and σ receptor antagonist that acts on Dopamine D1, σ, Dopamine D1, and 5-HT2 receptors. Cinuperone shows significantly higher affinity for σ receptors than for Dopamine D1 receptors, and only exhibits moderate binding activity for dopamine D2 receptors. Cinuperone can be used in the research of central nervous system diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 82117-51-9
- 分子式: C23H24FN3O
- 分子量:377.46
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Sigma Receptor アイソフォーム固有の製品をすべて表示
MoreDopamine Receptor アイソフォーム固有の製品をすべて表示
More5-HT Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
|
D2 Receptor 75 nM (IC50) |
D1 Receptor 6200 nM (IC50) |
5-HT2 Receptor 240 nM (IC50) |
Cinuperone potently inhibits [3H]-spiperone binding to dopamine2 receptors in rat striatal membranes with an IC50 of 76 nM[2].
Cinuperone weakly inhibits [3H]-SCH 23390 binding to dopamine1 receptors in rat striatal membranes with an IC50 of 6200 nM[2].
Cinuperone potently inhibits [3H]-haloperidol binding to σ receptors in rat cerebellar membranes with an IC50 of 54 nM[2].
Cinuperone moderately inhibits [3H]-ketanserin binding to 5-HT2 receptors in rat frontal cortex membranes with an IC50 of 240 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cinuperone (10 μmol/kg; administered 30 minutes prior to apomorphine) antagonizes apomorphine-induced climbing in male albino mice with an ED50 of 10 μmol/kg[2].
Cinuperone (15 μmol/kg; administered 30 minutes prior to apomorphine) antagonizes apomorphine-induced yawning in male albino rats with an ED50 of 15 μmol/kg[2].
Cinuperone (0.97 μmol/kg; i.p.; administered 30 minutes prior to quipazine) antagonizes quipazine-induced head twitches in male albino rats with an ED50 of 0.97 μmol/kg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 82117-51-9
-
分子量 377.46
-
分子式 C23H24FN3O
-
SMILES
O=C(C1=CC=C(F)C=C1)CCCN2CCN(C=3N=CC4=CC=CC=C4C3)CC2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cinuperone 関連分類
HY-W754019 関連分類
Powered by Bioz