Dimethothiazine
Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 7456-24-8
- 分子式: C19H25N3O2S2
- 分子量:391.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
Histamine, 5-HT[1]
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cats (decerebrate model; the carotid arteries were clamped and the mid-brain sectioned approximately between the colliculae)[2]
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Dosage:0.5, 1, 2, 4, 8 and 16 mg/kg
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Administration:i.v.; single dosage
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Result:Reduced the discharge frequency of primary and secondary endings at 1-4 mg/kg.
Reduced the sensitivity of the muscle spindle to stretch in preparations with intact ventral roots.
Reduced the activity of the dynamic fusimotor fibres.
化学情報
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CAS 番号 7456-24-8
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分子量 391.55
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分子式 C19H25N3O2S2
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SMILES
O=S(C(C=C1N2CC(N(C)C)C)=CC=C1SC3=C2C=CC=C3)(N(C)C)=O
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別名
Dimetotiazine; Fonazine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Nattero G, et al. Use of dimethothiazine in the prevention of hemicrania. Minerva Med. 1977 Mar 17;68(13):839-45. [Content Brief]
[2]. Maxwell DR, Rhodes KF. The effects of dimethothiazine on muscle spindle activity in the decerebrate cat. Br J Pharmacol. 1970 Jul;39(3):520-32. [Content Brief]
[3]. Griffiths MI, et al. The use of dimethothiazine in the treatment of childhood cerebral palsy. Dev Med Child Neurol. 1973 Feb;15(1):25-32. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dimethothiazine 関連分類
HY-A0157 関連分類
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